23 research outputs found
The efficiency of replenishment of acute blood loss by an experimental blood substitute comprising humanβs umbilical cord blood red blood cells
Π’ΠΎ assess the effectiveness of the experimental blood substitute containing erythrocytes of human umbilical cord blood, were analyzed the dynamics of indicators of cardiovascular and respiratory systems, quantitative indicators of red blood, the severity of hemolysis in dogs within 24 hours after equivalent replenishment of acute blood loss for about 50% of the volume of circulating blood. The comparative drug was the adult human packed RBCs, used in clinical practice. It was found that after replenishment of blood loss in dogs, hemolytic anemia developed less pronounced after transfusion of the blood substitute with erythrocytes of human umbilical cord blood. Indicators of cardiovascular and respiratory systems were restored to the baseline in 24 hours after replenishment of acute blood loss by an experimental blood substitute with human umbilical cord blood erythrocytes with persistent changes after transfusion of the adult human packed RBCs. The relatively higher efficiency of the experimental blood substitute is due to the structural and functional stability of erythrocytes in the umbilical cord blood. A conclusion was made about the prospects of development of blood substitutes-oxygen carriers containing human umbilical cord blood erythrocytes.Π‘ ΡΠ΅Π»ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²Π΅Π·Π°ΠΌΠ΅Π½ΠΈΡΠ΅Π»Ρ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π³ΠΎ ΡΡΠΈΡΡΠΎΡΠΈΡΡ ΠΏΡΠΏΠΎΠ²ΠΈΠ½Π½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΈ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ, Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Π³Π΅ΠΌΠΎΠ»ΠΈΠ·Π° Ρ ΡΠΎΠ±Π°ΠΊ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 24 ΡΠ°ΡΠΎΠ² ΠΏΠΎΡΠ»Π΅ Π²ΠΎΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΎΡΡΡΠΎΠΉ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΎΠΏΠΎΡΠ΅ΡΠΈ ΠΎΠΊΠΎΠ»ΠΎ 50% ΠΎΡ ΠΎΠ±ΡΠ΅ΠΌΠ° ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠ΅ΠΉ ΠΊΡΠΎΠ²ΠΈ. ΠΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠ»ΡΠΆΠΈΠ»Π° ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΡΠ½Π°Ρ ΠΌΠ°ΡΡΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΠ°Ρ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΠΎΡΠ»Π΅ Π²ΠΎΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΊΡΠΎΠ²ΠΎΠΏΠΎΡΠ΅ΡΠΈ Ρ ΡΠΎΠ±Π°ΠΊ ΡΠ°Π·Π²ΠΈΠ²Π°Π»Π°ΡΡ Π³Π΅ΠΌΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π°Π½Π΅ΠΌΠΈΡ, ΠΌΠ΅Π½Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½Π°Ρ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΡΡΠ·ΠΈΠΈ ΠΊΡΠΎΠ²Π΅Π·Π°ΠΌΠ΅Π½ΠΈΡΠ΅Π»Ρ Ρ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΠΌΠΈ ΠΏΡΠΏΠΎΠ²ΠΈΠ½Π½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΈ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌ Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π»ΠΈΡΡ Π΄ΠΎ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ ΡΠ΅ΡΠ΅Π· 24 ΡΠ°ΡΠ° ΠΏΠΎΡΠ»Π΅ Π²ΠΎΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΊΡΠΎΠ²ΠΎΠΏΠΎΡΠ΅ΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ ΠΊΡΠΎΠ²Π΅Π·Π°ΠΌΠ΅Π½ΠΈΡΠ΅Π»Π΅ΠΌ Ρ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΠΌΠΈ ΠΏΡΠΏΠΎΠ²ΠΈΠ½Π½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΏΡΠΈ ΡΠΎΡ
ΡΠ°Π½ΡΡΡΠΈΡ
ΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΡ
ΠΏΠΎΡΠ»Π΅ Π²Π»ΠΈΠ²Π°Π½ΠΈΡ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²Π΅Π·Π°ΠΌΠ΅Π½ΠΈΡΠ΅Π»Ρ ΠΎΠ±ΡΡΡΠ½ΡΠ΅ΡΡΡ ΡΡΡΡΠΊΡΡΡΠ½ΠΎ-ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡΡ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΏΠΎΠ²ΠΈΠ½Π½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ. Π‘Π΄Π΅Π»Π°Π½ΠΎ Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΎ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²Π΅Π·Π°ΠΌΠ΅Π½ΠΈΡΠ΅Π»Π΅ΠΉ-ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ² ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΡΡΠΈΡΡΠΎΡΠΈΡΡ ΠΏΡΠΏΠΎΠ²ΠΈΠ½Π½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°