Gauge approach to superfluid density in underdoped cuprates

We prove that a gauge approach based on a composite structure of the hole in hole-doped cuprates is able to capture analytically many features of the experimental data on superfluid density in the moderate-underdoping to nearly-optimal doping region, including critical exponent, the Uemura relation and near universality of the normalized superfluid density.Comment: 13 pages, 2 figures, accepted for publication in EP

Superfluid density in cuprates: hints on gauge compositeness of the holes

We show that several features (the three-dimensional XY universality for moderate underdoping, the almost-BCS behaviour for moderate overdoping and the critical exponent) of the superfluid density in hole-doped cuprates hint at a composite structure of the holes. This idea can be implemented in a spin-charge gauge approach to the $t - t' - J$ model and provides indeed good agreement with available experimental data.Comment: 5 pages, 1 figure, to be published in the proceedings of the International Conference in Superconductivty and Magnetism ICSM201

Beliaev damping of the Goldstone mode in atomic Fermi superfluids

Beliaev damping in a superfluid is the decay of a collective excitation into two lower frequency collective excitations; it represents the only decay mode for a bosonic collective excitation in a superfluid at T = 0. The standard treatment for this decay assumes a linear spectrum, which in turn implies that the final state momenta must be collinear to the initial state. We extend this treatment, showing that the inclusion of a gradient term in the Hamiltonian yields a realistic spectrum for the bosonic excitations; we then derive a formula for the decay rate of such excitations, and show that even moderate nonlinearities in the spectrum can yield substantial deviations from the standard result. We apply our result to an attractive Fermi gas in the BCS-BEC crossover: here the low-energy bosonic collective excitations are density oscillations driven by the phase of the pairing order field. These collective excitations, which are gapless modes as a consequence of the Goldstone mechanism, have a spectrum which is well established both theoretically and experimentally, and whose linewidth, we show, is determined at low temperatures by the Beliaev decay mechanism.Comment: 8 pages, 3 figure

Transport Properties in the "Strange Metal Phase" of High Tc Cuprates: Spin-Charge Gauge Theory Versus Experiments

The SU(2)xU(1) Chern-Simons spin-charge gauge approach developed earlier to describe the transport properties of the cuprate superconductors in the ``pseudogap'' regime, in particular, the metal-insulator crossover of the in-plane resistivity, is generalized to the ``strange metal'' phase at higher temperature/doping. The short-range antiferromagnetic order and the gauge field fluctuations, which were the key ingredients in the theory for the pseudogap phase, also play an important role in the present case. The main difference between these two phases is caused by the existence of an underlying statistical $\pi$-flux lattice for charge carriers in the former case, whereas the background flux is absent in the latter case. The Fermi surface then changes from small ``arcs'' in the pseudogap to a rather large closed line in the strange metal phase. As a consequence the celebrated linear in T dependence of the in-plane and out-of-plane resistivity is shown explicitly to recover. The doping concentration and temperature dependence of theoretically calculated in-plane and out-of-plane resistivity, spin-relaxation rate and AC conductivity are compared with experimental data, showing good agreement.Comment: 14 pages, 5 .eps figures, submitted to Phys. Rev. B, revised version submitted on 24 Oc

Predictive biomarkers for checkpoint inhibitor-based immunotherapy: The Galectin-3 signature in NSCLCs

Checkpoint inhibitor-based immunotherapy is opening a promising scenario in oncology, with objective responses registered in multiple cancer types. However, reliable predictive markers of tumor responsiveness are still lacking. These markers need to be urgently identified for a better selection of patients that can be candidates for immunotherapy. In this pilot study, a cohort of 34 consecutive patients bearing programmed death-ligand 1 (PD-L1)-positive non-small cell lung carcinoma (NSCLC), treated with pembrolizumab, was considered. The retrospective immuno-phenotypic analysis performed on the original tumor biopsies allowed for the identification of a specific “galectin signature”, which strongly correlated with tumor responsiveness to anti PD-1 immunotherapy. We observed that the large majority of patients (about 90%) with high galectin-3 tumor expression (score 3+) showed an early and dramatic progression of the disease after three cycles of treatments. In contrast, all patients with negative or low/intermediate expression of galectin-3 in tumor cells showed an early and durable objective response to pembrolizumab, indicating galectin-3 as an interesting predictive marker of tumor responsiveness. The galectin-3 signature, at least in NSCLCs, promises a better selection of patient candidates for immunotherapy, reducing unnecessary treatment exposures and social costs. A large multicenter study is ongoing to validate this finding

The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one

In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice. We here highlight and discuss the need to take advantage of the common immune targets to design combined strategies to increase clinical responses

Critical Hysteresis in Random Field XY and Heisenberg Models

We study zero-temperature hysteresis in random-field XY and Heisenberg models in the zero-frequency limit of a cyclic driving field. We consider three distributions of the random field and present exact solutions in the mean field limit. The results show a strong effect of the form of disorder on critical hysteresis as well as the shape of hysteresis loops. A discrepancy with an earlier study based on the renormalization group is resolved.Comment: 10 pages, 6 figures; this is published version (added some text and references

Spin-charge gauge approach to metal-insulator crossover and transport properties in High-Tc_c cuprates

The spin-charge gauge approach to consider the metal-insulator crossover (MIC) and other anomalous transport properties in High-T$_c$ cuprates is briefly reviewed. A U(1) field gauging the global charge symmetry and an SU(2) field gauging the global spin-rotational symmetry are introduced to study the two-dimensional $t-J$ model in the limit $t\gg J$. The MIC as a clue to the understanding of the ``pseudogap'' (PG) phase, is attributed to the competition between the short-range antiferromagnetic order and dissipative motion of charge carriers coupled to the slave-particle gauge field. The composite particle formed by binding the charge carrier (holon) and spin excitation (spinon) via the slave particle gauge field exhibits a number of peculiar properties, and the calculated results are in good agreement with experimental data for both PG and ``strange metal'' phases. Connections to other gauge field approaches in studying the strong correlation problem are also briefly outlined.Comment: 32 pages, to appear in the special issue on "Correlated Electrons" of J. Phys.: Condens. Mat