Approaching a topological phase transition in Majorana nanowires

Recent experiments have produced mounting evidence of Majorana zero modes in nanowire-superconductor hybrids. Signatures of an expected topological phase transition accompanying the onset of these modes nevertheless remain elusive. We investigate a fundamental question concerning this issue: Do well-formed Majorana modes necessarily entail a sharp phase transition in these setups? Assuming reasonable parameters, we argue that finite-size effects can dramatically smooth this putative transition into a crossover, even in systems large enough to support well-localized Majorana modes. We propose overcoming such finite-size effects by examining the behavior of low-lying excited states through tunneling spectroscopy. In particular, the excited-state energies exhibit characteristic field and density dependence, and scaling with system size, that expose an approaching topological phase transition. We suggest several experiments for extracting the predicted behavior. As a useful byproduct, the protocols also allow one to measure the wire's spin-orbit coupling directly in its superconducting environment.Comment: 13 pages, 8 figure

Improved Pairwise Measurement-Based Surface Code

We devise a new realization of the surface code on a rectangular lattice of qubits utilizing single-qubit and nearest-neighbor two-qubit Pauli measurements and three auxiliary qubits per plaquette. This realization gains substantial advantages over prior pairwise measurement-based realizations of the surface code. It has a short operation period of 4 steps and our performance analysis for a standard circuit noise model yields a high fault-tolerance threshold of approximately $0.66\%$. The syndrome extraction circuits avoid bidirectional hook errors, so we can achieve full code distance by choosing appropriate boundary conditions. We also construct variants of the syndrome extraction circuits that entirely prevent hook errors, at the cost of larger circuit depth. This achieves full distance regardless of boundary conditions, with only a modest decrease in the threshold. Furthermore, we propose an efficient strategy for dealing with dead components (qubits and measurements) in our surface code realization, which can be adopted more generally for other surface code realizations. This new surface code realization is highly optimized for Majorana-based hardware, accounting for constraints imposed by layouts and the implementation of measurements, making it competitive with the recently proposed Floquet codes.Comment: 38 pages, 32 figure

Processing quantum information with relativistic motion of atoms

We show that particle detectors, such as two-level atoms, in noninertial motion (or in gravitational fields) could be used to build quantum gates for the processing of quantum information. Concretely, we show that through suitably chosen noninertial trajectories of the detectors the interaction Hamiltonian's time dependence can be modulated to yield arbitrary rotations in the Bloch sphere due to relativistic quantum effects

Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance.

It is well known that visceral adipose tissue (VAT) is associated with insulin resistance (IR). Considerable debate remains concerning the potential positive effect of thigh subcutaneous adipose tissue (TSAT). Our objective was to observe whether VAT and TSAT are opposite, synergistic or additive for both peripheral and hepatic IR. Fifty-two volunteers (21 male/31 female) between 30 and 75 years old were recruited from the general population. All subjects were sedentary overweight or obese (mean BMI 33.0 ± 3.4 kg/m(2)). Insulin sensitivity was determined by a 4-h hyperinsulinemic-euglycemic clamp with stable isotope tracer dilution. Total body fat and lean body mass were determined by dual X-ray absorptiometry. Abdominal and mid-thigh adiposity was determined by computed tomography. VAT was negatively associated with peripheral insulin sensitivity, while TSAT, in contrast, was positively associated with peripheral insulin sensitivity. Subjects with a combination of low VAT and high TSAT had the highest insulin sensitivity, subjects with a combination of high VAT and low TSAT were the most insulin resistant. These associations remained significant after adjusting for age and gender. These data confirm that visceral excess abdominal adiposity is associated with IR across a range of middle-age to older men and women, and further suggest that higher thigh subcutaneous fat is favorably associated with better insulin sensitivity. This strongly suggests that these two distinct fat distribution phenotypes should both be considered in IR as important determinants of cardiometabolic risk

Global Wheat Head Detection (GWHD) dataset: a large and diverse dataset of high resolution RGB labelled images to develop and benchmark wheat head detection methods

Detection of wheat heads is an important task allowing to estimate pertinent traits including head population density and head characteristics such as sanitary state, size, maturity stage and the presence of awns. Several studies developed methods for wheat head detection from high-resolution RGB imagery. They are based on computer vision and machine learning and are generally calibrated and validated on limited datasets. However, variability in observational conditions, genotypic differences, development stages, head orientation represents a challenge in computer vision. Further, possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex. Through a joint international collaborative effort, we have built a large, diverse and well-labelled dataset, the Global Wheat Head detection (GWHD) dataset. It contains 4,700 high-resolution RGB images and 190,000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes. Guidelines for image acquisition, associating minimum metadata to respect FAIR principles and consistent head labelling methods are proposed when developing new head detection datasets. The GWHD is publicly available at http://www.global-wheat.com/ and aimed at developing and benchmarking methods for wheat head detection.Comment: 16 pages, 7 figures, Dataset pape

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

\ua9 The Author(s) 2024.A robust and efficient cellular response to lysosomal membrane damage prevents leakage from the lysosome lumen into the cytoplasm. This response is understood to happen through either lysosomal membrane repair or lysophagy. Here we report exocytosis as a third response mechanism to lysosomal damage, which is further potentiated when membrane repair or lysosomal degradation mechanisms are impaired. We show that Connexin43 (Cx43), a protein canonically associated with gap junctions, is recruited from the plasma membrane to damaged lysosomes, promoting their secretion and accelerating cell recovery. The effects of Cx43 on lysosome exocytosis are mediated by a reorganization of the actin cytoskeleton that increases plasma membrane fluidity and decreases cell stiffness. Furthermore, we demonstrate that Cx43 interacts with the actin nucleator Arp2, the activity of which was shown to be necessary for Cx43-mediated actin rearrangement and lysosomal exocytosis following damage. These results define a novel mechanism of lysosomal quality control whereby Cx43-mediated actin remodelling potentiates the secretion of damaged lysosomes

Improved Pairwise Measurement-Based Surface Code

We devise a new realization of the surface code on a rectangular lattice of qubits utilizing single-qubit and nearest-neighbor two-qubit Pauli measurements and three auxiliary qubits per plaquette. This realization gains substantial advantages over prior pairwise measurement-based realizations of the surface code. It has a short operation period of 4 steps and our performance analysis for a standard circuit noise model yields a high fault-tolerance threshold of approximately $0.66\%$. The syndrome extraction circuits avoid bidirectional hook errors, so we can achieve full code distance by choosing appropriate boundary conditions. We also construct variants of the syndrome extraction circuits that entirely prevent hook errors, at the cost of larger circuit depth. This achieves full distance regardless of boundary conditions, with only a modest decrease in the threshold. Furthermore, we propose an efficient strategy for dealing with dead components (qubits and measurements) in our surface code realization, which can be adopted more generally for other surface code realizations. This new surface code realization is highly optimized for Majorana-based hardware, accounting for constraints imposed by layouts and the implementation of measurements, making it competitive with the recently proposed Floquet codes