Cyclic (Noncyclic) ϕ-condensing operator and its application to a system of differential equations

We establish a best proximity pair theorem for noncyclic ϕ-condensing operators in strictly convex Banach spaces by using a measure of noncompactness. We also obtain a counterpart result for cyclic ϕ-condensing operators in Banach spaces to guarantee the existence of best proximity points, and so, an extension of Darbo’s fixed point theorem will be concluded. As an application of our results, we study the existence of a global optimal solution for a system of ordinary differential equations

On a stochastic disease model with vaccination

We propose a stochastic disease model where vaccination is included and such that the immunity isn\u2019t permanent. The existence, uniqueness and positivity of the solution and the stability of disease free equilibrium is studied. The numerical simulation is done

Editorial

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A Recommender System for Telecom Users: Experimental Evaluation of Recommendation Algorithms

The increasing flourish of available services in telecom domain offers more choices to the end user. On the other hand, such wide offer cannot be completely evaluated by the user, and some services may pass unobserved even if useful. To face this issue, the usage of recommendation systems in telecom domain is growing, to directly notify the user about the presence of services which may meet user interests. Recommendation can be seen as an advanced form of personalization, because user preferences are used to predict the interests of users for a new service. In this paper we propose a recommender system for users of telecom services, based on different collaborative filtering algorithms applied to a complex data-set of telecom users. Experiments on the recommendation performance and accuracy are conducted to test the different effects of different algorithms on a data set coming from the telecom domain

The Formation and Application of Polymeric Micro- and Nanoparticles

Nano- and microparticles are used in the pharmaceutical industry for sustained release drug delivery systems. For example, polymeric particles are currently used as an FDA-approved drug delivery system for leuprolide acetate to treat prostate cancer1. Our drug of interest is CPDI-02 (formerly known as EP67)—a C5a-derived decapeptide agonist of the C5a Receptor (CD88) that activates mononuclear phagocytes to produce an immune response while potentially minimizing neutrophil-mediated toxicity2. Currently in the Vetro Lab, CPDI-02 is being tested on pigs and mice to treat methicillin-resistant Staphylococcus aureus (MRSA) infections and as the adjuvant for a vaccine for cytomegalovirus (CMV). This investigation explored formulation parameters that impact particle size and loading of CPDI-02 in a traditional oil-in-water (O/W) emulsion. We also explored adapting the formulation using microfluidic chips to generate nano- and microparticles and improve run-to-run consistency in particle size.https://digitalcommons.unmc.edu/surp2022/1004/thumbnail.jp

Coupled fixed point results in cone metric spaces for -compatible mappings

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An MPEG-7 scheme for semantic content modelling and filtering of digital video

Abstract Part 5 of the MPEG-7 standard specifies Multimedia Description Schemes (MDS); that is, the format multimedia content models should conform to in order to ensure interoperability across multiple platforms and applications. However, the standard does not specify how the content or the associated model may be filtered. This paper proposes an MPEG-7 scheme which can be deployed for digital video content modelling and filtering. The proposed scheme, COSMOS-7, produces rich and multi-faceted semantic content models and supports a content-based filtering approach that only analyses content relating directly to the preferred content requirements of the user. We present details of the scheme, front-end systems used for content modelling and filtering and experiences with a number of users

The prognostic value of the myeloid-mediated immunosuppression marker Arginase-1 in classic Hodgkin Lymphoma

Neutrophilia is hallmark of classic Hodgkin Lymphoma (cHL), but its precise characterization remains elusive. We aimed at investigating the immunosuppressive role of high-density neutrophils in HL

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

New glucuronosyldiacylglycerol (GlcADG) analogues based on a 2-O-\u3b2-D-glucopyranosyl-sn-glycerol scaffold and carrying one or two acyl chains of different lengths have been synthesized as phosphatidylinositol 3-phosphate (PI3P) mimics targeting the protein kinase Akt. Akt inhibitory effect of prepared compounds, was assayed using an in vitro kinase assay. The antiproliferative activity of the compounds was tested in the human ovarian carcinoma IGROV-1 cell line in which we found that two of them could inhibit proliferation, in keeping with the target inhibitory effect