The X-ray line and continuum emission from a solar active region

The X-ray spectrum of the quiet sun in the energy range 2.3 - 6.9 keV was observed from an Aerobee rocket using an uncollimated graphite crystal spectrometer. These results and spatial measurements made with an onboard modulation collimator are analyzed using solar models

Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype.

Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity and reduced metabolism. Kiss1r is expressed in brain and multiple peripheral tissues, but it is unknown which is responsible for the metabolic phenotype. Here, we sought to confirm that 1) the metabolic phenotype of the gene trap Kiss1r KOs is due to disruption of kisspeptin signaling and not off-target effects of viral mutagenesis, and 2) the Kiss1r flox line is suitable for creating conditional KOs to study the metabolic phenotype. We used Cre/lox technology (Zp3-Cre/Kiss1r flox) to develop a new global Kiss1r KO ("Kiss1r gKO") to compare with the original gene trap KO phenotype. We confirmed that deleting exon 2 of Kiss1r from the entire body induces hypogonadism in both sexes. Moreover, global deletion of Kiss1r induced obesity in females, but not males, along with increased adiposity and impaired glucose tolerance, similar to the gene trap Kiss1r KOs. Likewise, Kiss1r gKO females had decreased VO2 and VCO2, likely underlying their obesity. These findings support that our previous results in gene trap Kiss1r KOs are due to disrupted kisspeptin signaling, and further highlight a role for Kiss1r signaling in energy expenditure and metabolism besides controlling reproduction. Moreover, given Kiss1r expression in multiple cell-types, our findings indicate that the Kiss1r flox line is viable for future investigations to isolate specific target cells of kisspeptin's metabolic effects

Tractably Modelling Dependence in Networks Beyond Exchangeability

We propose a general framework for modelling network data that is designed to describe aspects of non-exchangeable networks. Conditional on latent (unobserved) variables, the edges of the network are generated by their finite growth history (with latent orders) while the marginal probabilities of the adjacency matrix are modeled by a generalization of a graph limit function (or a graphon). In particular, we study the estimation, clustering and degree behavior of the network in our setting. We determine (i) the minimax estimator of a composite graphon with respect to squared error loss; (ii) that spectral clustering is able to consistently detect the latent membership when the block-wise constant composite graphon is considered under additional conditions; and (iii) we are able to construct models with heavy-tailed empirical degrees under specific scenarios and parameter choices. This explores why and under which general conditions non-exchangeable network data can be described by a stochastic block model. The new modelling framework is able to capture empirically important characteristics of network data such as sparsity combined with heavy tailed degree distribution, and add understanding as to what generative mechanisms will make them arise. Keywords: statistical network analysis, exchangeable arrays, stochastic block model, nonlinear stochastic processes

Associations of Adiponectin with Adiposity, Insulin Sensitivity, and Diet in Young, Healthy, Mexican Americans and Non-Latino White Adults.

Low circulating adiponectin levels may contribute to higher diabetes risk among Mexican Americans (MA) compared to non-Latino whites (NLW). Our objective was to determine if among young healthy adult MAs have lower adiponectin than NLWs, independent of differences in adiposity. In addition, we explored associations between adiponectin and diet. This was an observational, cross-sectional study of healthy MA and NLW adults living in Colorado (U.S.A.). We measured plasma total adiponectin, adiposity (BMI, and visceral adipose tissue), insulin sensitivity (IVGTT), and self-reported dietary intake in 43 MA and NLW adults. Mean adiponectin levels were 40% lower among MA than NLW (5.8 ± 3.3 vs. 10.7 ± 4.2 µg/mL, p = 0.0003), and this difference persisted after controlling for age, sex, BMI, and visceral adiposity. Lower adiponectin in MA was associated with lower insulin sensitivity (R² = 0.42, p < 0.01). Lower adiponectin was also associated with higher dietary glycemic index, lower intake of vegetables, higher intake of trans fat, and higher intake of grains. Our findings confirm that ethnic differences in adiponectin reflect differences in insulin sensitivity, but suggest that these are not due to differences in adiposity. Observed associations between adiponectin and diet support the need for future studies exploring the regulation of adiponectin by diet and other environmental factors

The KX method for producing K-band flux-limited samples of quasars

The longstanding question of the extent to which the quasar population is affected by dust extinction, within host galaxies or galaxies along the line of sight, remains open. More generally, the spectral energy distributions of quasars vary significantly and flux-limited samples defined at different wavelengths include different quasars. Surveys employing flux measurements at widely separated wavelengths are necessary to characterise fully the spectral properties of the quasar population. The availability of panoramic near-infrared detectors on large telescopes provides the opportunity to undertake surveys capable of establishing the importance of extinction by dust on the observed population of quasars. We introduce an efficient method for selecting K-band, flux-limited samples of quasars, termed ``KX'' by analogy with the UVX method. This method exploits the difference between the power-law nature of quasar spectra and the convex spectra of stars: quasars are relatively brighter than stars at both short wavelengths (the UVX method) and long wavelengths (the KX method). We consider the feasibility of undertaking a large-area KX survey for damped Ly-alpha galaxies and gravitational lenses using the planned UKIRT wide-field near-infrared camera.Comment: 6 pages, 3 figures, to appear in MNRA

Elastic properties of cubic crystals: Every's versus Blackman's diagram

Blackman's diagram of two dimensionless ratios of elastic constants is frequently used to correlate elastic properties of cubic crystals with interatomic bondings. Every's diagram of a different set of two dimensionless variables was used by us for classification of various properties of such crystals. We compare these two ways of characterization of elastic properties of cubic materials and consider the description of various groups of materials, e.g. simple metals, oxides, and alkali halides. With exception of intermediate valent compounds, the correlation coefficients for Every's diagrams of various groups of materials are greater than for Blackaman's diagrams, revealing the existence of a linear relationship between two dimensionless Every's variables. Alignment of elements and compounds along lines of constant Poisson's ratio $\nu(,\textbf{m})$, ($\textbf{m}$ arbitrary perpendicular to ) is observed. Division of the stability region in Blackman's diagram into region of complete auxetics, auxetics and non-auxetics is introduced. Correlations of a scaling and an acoustic anisotropy parameter are considered.Comment: 8 pages, 9 figures, presented on The Ninth International School on Theoretical Physics "Symmetry and Structural Properties of Condensed Matter", 5 - 12 September 2007, Myczkowce, Polan

Quantum Degenerate Exciton-Polaritons in Thermal Equilibrium

We study the momentum distribution and relaxation dynamics of semiconductor microcavity polaritons by angle-resolved and time-resolved spectroscopy. Above a critical pump level, the thermalization time of polaritons at positive detunings becomes shorter than their lifetime, and the polaritons form a quantum degenerate Bose-Einstein distribution in thermal equilibrium with the lattice.Comment: Updated with the published versio