Quantum Gravity and Inflation

We review some perturbative results obtained in quantum gravity in an accelerating cosmological background. We then describe a class of non-local, purely gravitational models which have the correct structure to reproduce the leading infrared logarithms of quantum gravitational back-reaction during the inflationary regime. These models end inflation in a distinctive phase of oscillations with slight and short violations of the weak energy condition and should, when coupled to matter, lead to rapid reheating. By elaborating this class of models we exhibit one that has the same behaviour during inflation, goes quiescent until the onset of matter domination, and induces a small, positive cosmological constant of about the right size thereafter. We also briefly comment on the primordial density perturbations that this class of models predict.Comment: 28 pages, 6 figures, lectures given at the 6th Aegean Summer School in Naxos, Greece, September 12-17, 2011 Version 2 has some typos correcte

Primordial Gravitational Waves Enhancement

We reconsider the enhancement of primordial gravitational waves that arises from a quantum gravitational model of inflation. A distinctive feature of this model is that the end of inflation witnesses a brief phase during which the Hubble parameter oscillates in sign, changing the usual Hubble friction to anti-friction. An earlier analysis of this model was based on numerically evolving the graviton mode functions after guessing their initial conditions near the end of inflation. The current study is based on an equation which directly evolves the normalized square of the magnitude. We are also able to make a very reliable estimate for the initial condition using a rapidly converging expansion for the sub-horizon regime. Results are obtained for the energy density per logarithmic wave number as a fraction of the critical density. These results exhibit how the enhanced signal depends upon the number of oscillatory periods; they also show the resonant effects associated with particular wave numbers.Comment: 25 pages, 14 figure

Possible Enhancement of High Frequency Gravitational Waves

We study the tensor perturbations in a class of non-local, purely gravitational models which naturally end inflation in a distinctive phase of oscillations with slight and short violations of the weak energy condition. We find the usual generic form for the tensor power spectrum. The presence of the oscillatory phase leads to an enhancement of gravitational waves with frequencies somewhat less than 10^{10} Hz.Comment: 27 pages, 11 figures, LaTeX.2

Microbiological surveillance of hospital ventilation systems in departments at high risk of nosocomial infections

The air in hospital wards with patients at high risk (Surgeries, Intensive Care Units and Bone Marrow Transplant Centers) has been surveyed less than the one in Operating Rooms. Therefore in this study we considered useful to verify the microbic contamination of the air of those wards evaluating the consistency of ventilation systems in relation also to the presence and location of HEPA absolute filters. Seven departments of Genoese San Martino Hospital at high risk of infection were taken into account. In there, environmental investigations have been performed by air samplings and by analyzing bacterial and fungal growth on plates after an incubation period. Almost 60% of all samples taken in wards yielded a positive result and the average values of bacterial and aspergillar charges measured at air flow emission openings decisively exceed the ones considered standard in operating rooms. Still, the average values of airborne bacterial charges were significantly higher in those wards equipped with central filters (p inf. 0.001), while as far as the aspergillar charge is concerned, no statistically relevant differences were noticed. In wards with ventilation system, the bacterial charge value raises from the emission grids to the middle of the room and to the aspiration grids, while the ward not equipped with a ventilation system presents in the middle of the room an average bacterial charge 2 to 10 times higher than the one in other wards. The average values regarding bacterial and aspergillar charges resulted quite high in all the departments surveyed. Nevertheless, if we take into account ventilation systems equipped with absolute filters HEPA located centrally or peripherally, it can be outlined that the air quality from the point of view of both microbic and aspergillar contamination turns out to be decisively better in systems with peripheral filters. Moreover, a compared analysis of the three Hematology wards allows us to infer that the presence of artificial ventilation systems can lower the bacterial and fungal compared with a ward with natural ventilation

Epigenetic deregulation of micrornas in rhabdomyosarcoma and neuroblastoma and translational perspectives

Gene expression control mediated by microRNAs and epigenetic remodeling of chromatin are interconnected processes often involved in feedback regulatory loops, which strictly guide proper tissue differentiation during embryonal development. Altered expression of microRNAs is one of the mechanisms leading to pathologic conditions, such as cancer. Several lines of evidence pointed to epigenetic alterations as responsible for aberrant microRNA expression in human cancers. Rhabdomyosarcoma and neuroblastoma are pediatric cancers derived from cells presenting features of skeletal muscle and neuronal precursors, respectively, blocked at different stages of differentiation. Consistently, tumor cells express tissue markers of origin but are unable to terminally differentiate. Several microRNAs playing a key role during tissue differentiation are often epigenetically downregulated in rhabdomyosarcoma and neuroblastoma and behave as tumor suppressors when re-expressed. Recently, inhibition of epigenetic modulators in adult tumors has provided encouraging results causing re-expression of anti-tumor master gene pathways. Thus, a similar approach could be used to correct the aberrant epigenetic regulation of microRNAs in rhabdomyosarcoma and neuroblastoma. The present review highlights the current insights on epigenetically deregulated microRNAs in rhabdomyosarcoma and neuroblastoma and their role in tumorigenesis and developmental pathways. The translational clinical implications and challenges regarding modulation of epigenetic chromatin remodeling/microRNAs interconnections are also discusse