Effectiveness of antihypertensive therapy in HIV-positive patients: evaluation to 144 weeks

Hypertension is more prevalent among HIV-infected subjects than in the general population, contributing to increased cardiovascular risk in HIV+ patients. The angiotensin II receptor blocker telmisartan is also a partial peroxisome proliferator activated receptor (PPAR)-γ agonist, with documented effects on improving hypertension, lipid metabolism and renal function. Therefore telmisartan was found to be the first choice for treatment of HIV+ hypertensive patients. Aim of this study was to evaluate the durability on 144 weeks of treatment with telmisartan in HIV+ patients. 13 HIV+ Caucasian male patients treated with combined antiretroviral therapy (cART) and discovered to be naïve hypertensive, were given 80 mg telmisartan daily. Systolic (SBP) and diastolic (DBP) blood pressure, viro-immunological, lipid and metabolic parameters, including triglycerides, cholesterol, insulin resistance (HOMA-IR), inflammatory markers, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), indexes of renal function and cardiovascular risk, microalbuminuria, cystatin C, were measured at baseline (T0), and after 24 (T24), 48 (T48), 72 (T72), 96 (T96), 120 (T120) and 144 (T144) weeks. Treatment with telmisartan decreased SBP and DBP levels during the 144 weeks of observation. We also observed improved HDL-cholesterol, HOMA-IR, microalbuminuria and cystatin C at the end of study. Triglycerides and total cholesterol significantly decreased and HDL-cholesterol significantly increased. Total cholesterol/HDL cholesterol ratio improved significantly. Throughout in the course of the trial our patients showed a significant improvement of the percentage of CD4+ and CD8+. Eventually in all 144 weeks of therapy with telmisartan 80 mg/day have not observed adverse events or dropouts. Telmisartan was effective in improving hypertension, lipid metabolism and renal function in 144 weeks of evaluation. It determines the improvement of cystatin C and microalbuminuria, markers of renal function and cardiovascular risk. Telmisartan doesn't interfere with cART, not interfering with the recovery of immunological HIV patients. Telmisartan has confirmed durability and effectiveness, excellent tolerability and an high persistance with a good blood pressure control. Therefore telmisartan reveals the first choice in the treatment of hypertension in HIV+ because of significant morbidity in this group of patients

Measurement of the Q(2) Dependence of the Deuteron Spin Structure Function g(1) and Its Moments at Low Q(2) with CLAS

We measured the g1 spin structure function of the deuteron at low Q2, where QCD can be approximated with chiral perturbation theory (χPT). The data cover the resonance region, up to an invariant mass of W ≈ 1.9  GeV. The generalized Gerasimov-Drell-Hearn sum, the moment Γd1 and the spin polarizability γ0d are precisely determined down to a minimum Q2 of 0.02  GeV2 for the first time, about 2.5 times lower than that of previous data. We compare them to several χPT calculations and models. These results are the first in a program of benchmark measurements of polarization observables in the χPT domain. We measured the g1 spin structure function of the deuteron at low Q2, where QCD can be approximated with chiral perturbation theory (χPT). The data cover the resonance region, up to an invariant mass of W ≈1.9  GeV. The generalized Gerasimov-Drell-Hearn sum, the moment Γ_{1}^{d} and the spin polarizability γ_{0}^{d} are precisely determined down to a minimum Q2 of 0.02  GeV2 for the first time, about 2.5 times lower than that of previous data. We compare them to several χPT calculations and models. These results are the first in a program of benchmark measurements of polarization observables in the χPT domain

On the background in the γp→ω(π0γ)p\gamma p \to \omega(\pi^0\gamma) p reaction and mixed event simulation

In this paper we evaluate sources of background for the $\gamma p \to \omega p$, with the $\omega$ detected through its $\pi^0 \gamma$ decay channel, to compare with the experiment carried out at ELSA. We find background from $\gamma p \to \pi^0 \pi^0 p$ followed by decay of a $\pi^0$ into two $\gamma$, recombining one $\pi^0$ and one $\gamma$, and from the $\gamma p \to \pi^0 \eta p$ reaction with subsequent decay of the $\eta$ into two photons. This background accounts for the data at $\pi^0 \gamma$ invariant masses beyond 700 MeV, but strength is missing at lower invariant masses which was attributed to photon misidentification events, which we simulate to get a good reproduction of the experimental background. Once this is done, we perform an event mixing simulation to reproduce the calculated background and we find that the method provides a good description of the background at low $\pi^0 \gamma$ invariant masses but fakes the background at high invariant masses, making background events at low invariant masses, which are due to $\gamma$ misidentification events, responsible for the background at high invariant masses which is due to the $\gamma p \to \pi^0 \pi^0 p$ and $\gamma p \to \pi^0 \eta p$ reactions.Comment: 10 pages, 5 figure

RFP-MSR Hybrid Reactor Model for Tritium Breeding and Actinides Transmutation †

The studies on the development of fusion-fission hybrid reactors (FFHR) have gained consensus in recent years as an intermediate step before fusion energy. This work proposes a possible approach to FFHRs based on the coupling of a Reversed Field Pinch fusion machine and a Molten Salt Subcritical fission test bed. The proposed test bed is characterized by the coexistence of a fast-neutron fission core and a dedicated thermal-neutron zone, allowing the performing of tritium breeding and actinides transmutation studies. The neutronic design solutions and the results obtained by the irradiation of FLiBe salt (inside the thermal-neutron zone) and of an actinide target (inside the core) are shown. The outcomes of the analysis reveal the potential of FFHR systems as breeding/burner systems. In particular, the results regarding tritium breeding are very encouraging as the system is demonstrated to be able to reach a very high Tritium Breeding Ratio

A new highly segmented start counter for the CLAS detector

The design, construction and performance of a highly segmented Start Counter are described. The Start Counter is an integral part of the trigger used in photon beam running with CLAS in Hall B at the Thomas Jefferson National Accelerator Facility (TJNAF). The Start Counter is constructed of 24 2.2-mm-thick single-ended scintillation paddles, forming a hermetic hexagon around the target region. This device measures the interaction time of the incoming photon in the target by detecting the outgoing particles. The counter provides complex trigger topologies, shows good efficiency and achieved a time resolution of 350 ps

Probing the nucleon structure with CLAS

An overview of recent results with CLAS is presented with emphasis on nucleon resonance studies, nucleon spin structure, and generalized parton distributions.Comment: Plenary talk presented at NSTAR 2007, Bonn, German

Quasi-elastic and inelastic inclusive electron scattering from an oxygen jet target

The results of an experiment on inclusive electron scattering from an oxygen jet target, performed in a wide range of energy and momentum transfer covering both quasi-elastic and $\Delta$(1232) resonance regions, are reported. In the former region the theoretical predictions, obtained including effects of nucleon-nucleon correlations in both initial and final states, give a good description of the experimental data. In the inelastic region a broadening as well as a damping of the resonant part of the cross section with respect to the free nucleon case is observed. The need of more detailed calculations including nuclear structure effects on the electroproduction cross section of nucleon resonances is highlighted.Comment: to appear in Nucl. Phys.