69 research outputs found
Hydraulic transport of coal /
No full textIncludes bibliographical references.Mode of access: Internet
Reduced thrombus formation in native blood of homozygous factor VII- deficient patients at high arterial wall shear rate
No full textReduced thrombus formation in native blood of homozygous factor VII- deficient patients at high arterial wall shear rate
No full textA critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
No full textLeukotriene A(4) Hydrolase (LTA(4)H) is a pro-inflammatory enzyme which generates the inflammatory mediator leukotriene B(4) (LTB(4)). LTA(4)H also possesses aminopeptidase activity with unknown substrate and physiological significance. We identified the neutrophil chemoattractant, Pro-Gly-Pro (PGP), as this physiological substrate. PGP is a biomarker for chronic obstructive pulmonary disease (COPD), and is implicated in neutrophil persistence in the lung. In acute neutrophil driven inflammation, PGP was degraded by LTA(4)H, which facilitated the resolution of inflammation. In contrast, cigarette smoke, a major risk factor for the development of COPD, selectively inhibited LTA(4)H aminopeptidase activity, which led to the accumulation of PGP and neutrophils. These studies imply that therapeutic strategies that inhibit LTA(4)H to prevent LTB(4) generation may not reduce neutrophil recruitment because of elevated PGP
omega-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of omega-hydroxy and omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4
No full textMetabolism of Cysteinyl Leukotrienes to Novel Polar Metabolites in the Rat and Endogenous Formation of Leukotriene D 4
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