Brain energy rescue:an emerging therapeutic concept for neurodegenerative disorders of ageing

The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. When glucose levels are limited, ketone bodies generated in the liver and lactate derived from exercising skeletal muscle can also become important energy substrates for the brain. In neurodegenerative disorders of ageing, brain glucose metabolism deteriorates in a progressive, region-specific and disease-specific manner — a problem that is best characterized in Alzheimer disease, where it begins presymptomatically. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics. The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes

Hydrothermal CO2 degassing in seismically active zones during the late Quaternary

Natural CO2 discharges are abundant in Turkey as evident from ongoing deposition of recent terrace-mound travertines and emplacement of significant travertine vein and breccia deposits in fractured damage zones of active fault systems. We report high-precision U-series age data for the vein carbonates combined with important field observations and geochemical data to evaluate the travertine veining and CO2 degassing history in seismically active areas. Field evidence suggests that travertine-filled veins and associated breccias represent hydrothermal eruption products, which probably formed by hydraulic fracturing in response to overpressure Of CO2-rich fluids. Stable isotope and REE data support the field observations and indicate that travertine veins formed as thermogene deposits from rapidly ascending CO2-rich fluids. Travertine veins from the Kirsehir geothermal field give U-series ages in a range from 10.6 +/- 0.3 ka to 86.16 +/- 1.24 ka, with a majority of ages failing between 10.6 +/- 0.3 and 11.3 +/- 0.2 ka. Vein samples from the Pamukkale geothermal field yield U-series ages between 21.1 +/- 0.1 ka and 73.6 +/- 0.6 ka. Two major age groups are evident in Pamukkale that cluster coherently around 21 ka and 25 ka. A large number of travertine veins we dated by high-precision U-series technique coincide with times of cold/dry climate events. This is different from surface sinter deposits in geothermal fields, which more frequently form during warm and wet periods. We propose that a significant reduction in surface discharge Of CO2 by spring or geothermal waters during dry climate periods may promote oversaturation of CO2 in deep reservoirs. Host rock fracturing in response to seismic shaking and fluid overpressure results in rapid exsolution and expansion of the dissolved gas and may lead to hydrothermal eruptions. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved

A co-condensation model for in-flight synthesis of metal-carbide nanoparticles in thermal plasma jet

We present a theoretical analysis of the formation, growth, and transport of two-component nanoparticles in thermal plasma jet. The approach of the aerosol science and the idea of multicomponent co-condensation are employed for the analysis. The processes of homogeneous nucleation, heterogeneous growth, and coagulations due to Brownian collisions are considered in combination with the convective and diffusive transport of particles and the reacting gases within an axisymmetric domain. As a particular example, the authors study multicomponent co-condensation of metal-carbide nanoparticles from various precursors in a DC plasma gun operating in an argon atmosphere