Treatment of head and neck cancer with photodynamic therapy: results after one year

Photodynamic therapy (PDT) is a new and promising treatment modality for the treatment of malignant disease. This paper reports the preliminary experience of our group in the use of this therapy for the treatment of tumours arising in the head and neck. The majority of treatments in these cases have used a second generation systemic photosensitizer, meta-tetrahydroxyphenylchlorin (m-THPC). Two other cases were treated with either Photofrin 2 (a first generation systemic sensitizer) or with the topical photosensitizer, delta-aminolaevulinic acid (delta-ALA).The initial results have been encouraging with good clinical responses evident in patients presenting with a variety of differing tumour types. We feel there is now sufficient evidence of the efficacy of this treatment to warrant a multicentre prospective study into the treatment of early head and neck cancer with PDT

Determination of phosphorus in natural waters: A historical review.

The aim of this paper is to introduce a virtual special issue that reviews the development of analytical approaches to the determination of phosphorus species in natural waters. The focus is on sampling and sample treatment, analytical methods and quality assurance of the data. The export of phosphorus from anthropogenic activities (from diffuse and point sources) can result in increased primary production and eutrophication, and potentially the seasonal development of toxic algal blooms, which can significantly impact on water quality. Therefore the quantification of phosphorus species in natural waters provides important baseline data for studying aquatic phosphorus biogeochemistry, assessing ecosystem health and monitoring compliance with legislation

The molybdenum blue reaction for the determination of orthophosphate revisited: Opening the black box

The molybdenum blue reaction, used predominantly for the determination of orthophosphate in environmental waters, has been perpetually modified and re-optimised over the years, but this important reaction in analytical chemistry is usually treated as something of a 'black box' in the analytical literature. A large number of papers describe a wide variety of reaction conditions and apparently different products (as determined by UV–visible spectroscopy) but a discussion of the chemistry underlying this behaviour is often addressed superficially or not at all. This review aims to rationalise the findings of the many 'optimised' molybdenum blue methods in the literature, mainly for environmental waters, in terms of the underlying polyoxometallate chemistry and offers suggestions for the further enhancement of this time-honoured analytical reaction

A photometrically and spectroscopically confirmed population of passive spiral galaxies

We have identified a population of passive spiral galaxies from photometry and integral field spectroscopy. We selected z < 0.035 spiral galaxies that have WISE colours consistent with little mid-infrared emission from warm dust. Matched aperture photometry of 51 spiral galaxies in ultraviolet, optical and mid-infrared show these galaxies have colours consistent with passive galaxies. Six galaxies form a spectroscopic pilot study and were observed using the Wide-Field Spectrograph to check for signs of nebular emission from star formation. We see no evidence of substantial nebular emission found in previous red spiral samples. These six galaxies possess absorption-line spectra with 4000 Å breaks consistent with an average luminosity-weighted age of 2.3 Gyr. Our photometric and integral field spectroscopic observations confirm the existence of a population of local passive spiral galaxies, implying that transformation into early-type morphologies is not required for the quenching of star formation

Seeing with sound? Exploring different characteristics of a visual-to-auditory sensory substitution device

Sensory substitution devices convert live visual images into auditory signals, for example with a web camera (to record the images), a computer (to perform the conversion) and headphones (to listen to the sounds). In a series of three experiments, the performance of one such device (‘The vOICe’) was assessed under various conditions on blindfolded sighted participants. The main task that we used involved identifying and locating objects placed on a table by holding a webcam (like a flashlight) or wearing it on the head (like a miner’s light). Identifying objects on a table was easier with a hand-held device, but locating the objects was easier with a head-mounted device. Brightness converted into loudness was less effective than the reverse contrast (dark being loud), suggesting that performance under these conditions (natural indoor lighting, novice users) is related more to the properties of the auditory signal (ie the amount of noise in it) than the cross-modal association between loudness and brightness. Individual differences in musical memory (detecting pitch changes in two sequences of notes) was related to the time taken to identify or recognise objects, but individual differences in self-reported vividness of visual imagery did not reliably predict performance across the experiments. In general, the results suggest that the auditory characteristics of the device may be more important for initial learning than visual associations

The drivers of AGN activity in galaxy clusters: AGN fraction as a function of mass and environment

We present an analysis of optical spectroscopically identified active galactic nuclei (AGN) down to a cluster magnitude of M * + 1 in a sample of six self-similar Sloan Digital Sky Survey galaxy clusters at z ~ 0.07. These clusters are specifically selected to lack significant substructure at bright limits in their central regions so that we are largely able to eliminate the local action of merging clusters on the frequency of AGN. We demonstrate that the AGN fraction increases significantly from the cluster centre to 1.5R virial , but tails off at larger radii. If only comparing the cluster core region to regions at ~2R virial , no significant variation would be found. We compute the AGN fraction by mass and show that massive galaxies (log(stellarmass) > 10.7) are host to a systematically higher fraction of AGN than lower mass galaxies at all radii from the cluster centre. We attribute this deficit of AGN in the cluster centre to the changing mix of galaxy types with radius. We use the WHAN diagnostic to separate weak AGN from 'retired' galaxies in which the main ionization mechanism comes from old stellar populations. These retired AGN are found at all radii, while the mass effect is much more pronounced: we find that massive galaxies are more likely to be in the retired class. Further, we show that our AGN have no special position inside galaxy clusters - they are neither preferentially located in the infall regions nor situated at local maxima of galaxy density as measured with ∑ 5 . However, we find that the most powerful AGN (with [O III] equivalent widths < -10 Å) reside at significant velocity offsets in the cluster, and this brings our analysis into agreement with previous work on X-ray-selected AGN. Our results suggest that if interactions with other galaxies are responsible for triggering AGN activity, the time lag between trigger and AGN enhancement must be sufficiently long to obfuscate the encounter site and wipe out the local galaxy density signal. © 2012 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society

Heterogeneity of inverted calcium II H:K ratio cluster galaxies

© 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society The ratio of calcium II H plus H∊ to calcium II K inverts as a galaxy stellar population moves from being dominated by older stars to possessing more A and B class stars. This ratio – the H:K ratio – can serve as an indicator of stellar populations younger than 200 Myr. In this work, we provide a new method to determine H:K, and apply it to spectra taken of cluster galaxies in Abell 3888. Although H:K is on average systematically lower for the cluster than for a wider field sample, we show that H:K does not have a simple relationship with other indices such as the equivalent widths of Hδ and [O II] beyond having a high value for strong [O II] emission. Moreover, strongly inverted galaxies with H:K > 1.1 have no preferred location within the cluster and are only slightly lower in their velocity dispersions around the cluster compared to strongly emitting [O II] galaxies. Our results indicate that selecting galaxies on H:K inversion results in a heterogeneous sample formed via a mixture of pathways that likely includes, but may not be limited to, merging spiral galaxies, and quiescent galaxies accreting lower mass, gas-rich companions. In concert with other selection criteria, H:K can provide a means to select a more ‘pure’ passive sample or to aid in the selection of highly star-forming galaxies, especially where other spectral line indicators such as H α may not have been observed

Moiré interferometry applied to fracture in titanium tubes

Despite there being a substantial body of evidence to the contrary, moiré interferometry is often regarded - even by some adherents - as a curiosity of the optics lab. The present work seeks to demonstrate still further that the method can be an effective tool for practical materials research and assessment, in this case, in a novel and challenging experimental application involving fracture testing of heat exchanger tube material, the work being conducted in a conventional materials test laboratory setting. The key to the utility of the present setup lies with the priority given to its optical efficiency. In standard fracture toughness tests, it is axiomatic that standard specimen geometries be used. A dilemma arises when a material's properties are transformed to a substantial degree by the final stages of its process of manufacture, and when the very nature of the finished form dictates that standard geometries cannot be produced. The focus of this investigation was to measure crack-tip opening displacements (CTODs) in thin-walled titanium tubes. Fringe patterns corresponding to in-plane displacement contours were obtained interferometrically and the method for extracting CTODs from these is described. Significant differences in yield, ultimate strength, elongation, and fracture behaviour were observed for different material orientations

Potential contribution of lysed bacterial cells to phosphorus solubilisation in two rewetted Australian pasture soils

Soil drying renders considerable amounts of phosphorus soluble upon rewetting, which may be partly derived from lysed microbial cells. Using direct bacterial cell counting in water and tetra-sodium pyrophosphate extracts of two Australian pasture soils, we found that almost all extractable cells were lysed following the rewetting of dry soils. The amounts of phosphorus in the lysed cells corresponded closely to the increases in water-extractable phosphorus following soil drying, suggesting that bacterial cell lysis is a major source of the released phosphorus

The effect of minor and major mergers on the evolution of low excitation radio galaxies

We use deep, μ r lesssim 28 mag arcsec−2, r-band imaging from the Dark Energy Camera Legacy Survey to search for past, or ongoing, merger activity in a sample of 282 low-excitation radio galaxies (LERGs) at z 4σ excess of major mergers in the LERGs with M * lesssim 1011 M⊙, with 10 ± 1.5% of these active galactic nuclei involved in such large-scale interactions compared to 3.2 ± 0.4% of control galaxies. This excess of major mergers in LERGs decreases with increasing stellar mass, vanishing by M * > 1011.3 M⊙. These observations show that minor mergers do not fuel LERGs, and are consistent with typical LERGs being powered by accretion of matter from their halo. Where LERGs are associated with major mergers, these objects may evolve into more efficiently accreting active galactic nuclei as the merger progresses and more gas falls on to the central engine