175 research outputs found
Soft sensor approach based on magnetic Barkhausen noise by means of the forming process punch-hole-rolling
The relevance of the magnetic Barkhausen noise (MBN) and the non-destructive characterization of material properties in near surface layers, has increased in recent years.With the development of new signal processing techniques, the method was further developed into a powerful evaluation technique and is used in various areas of online and offline measurement. In addition to the established use in the detection of grinding burn, the method is increasingly used in the context of soft sensors for property controlled processes, due to its short analysis times. By a detailed description of a soft sensor concept for the novel forming process punch-hole-rolling this work focuses on the offline characterization of the process specific cause-effect relationships. This is done by analyzing the process interactions as well as the surface layer state by a metallographic investigation. Additionally a non-destructive characterization by means of MBN was done and correlated with the surface layer state. This provides important findings for the use of a MBN-sensor in a soft sensor concept and the potential integration into the forming process
Word processing as an act of collaboration: description of a media artwork
As described in an earlier contribution to the JMP (Photography as an act of collaboration - Vol 15, Issue 3), my research explores the possibilities and implications of treating the camera and the photographic process as an active collaborator in the creation of scenes, events and ‘moments’ that did not exist until brought into being by the act of photographing them. The media artwork described here is the result of an experiment to explore the possibility of establishing a similarly collaborative relationship with the ‘agency’ of word-processing software that I have endeavoured to establish with the medium of photography. Despite comprehensively stripping the original text of both sense and sequence, the resulting text not only retains an uncanny degree of consistency with both the style and meaning of the original, but also reveals insights which had been only latent within the original. The result would appear to reinforce the findings of my previous research in photographic practice: that, by giving up conscious, rational control over the means of expression, we can (sometimes) create the conditions necessary for a constructive and often illuminating dialogue with the deus ex machina
Latest Developments from the S-DALINAC*
The S-DALINAC is a 130 MeV superconducting recirculating electron accelerator serving several nuclear and radiation physics experiments as well as driving an infrared free-electron laser. A system of normal conducting rf resonators for noninvasive beam position and current measurement was established. For the measurement of gamma-radiation inside the accelerator cave a system of Compton diodes has been developed and tested. Detailed investigations of the transverse phasespace were carried out with a tomographical reconstruction method of optical transition radiation spots. The method can be applied also to non-Gaussian phasespace distributions. The results are in good accordance with simulations. To improve the quality factor of the superconducting 3 GHz cavities, an external 2K testcryostat was commissioned. The influence of electro-chemical polishing and magnetic shielding is currently under investigation. A digital rf-feedback-system for the accelerator cavities is being developed in order to improve the energy spread of the beam of the S-DALINAC. * Supported by the BMBF under contract no. 06 DA 820, the DFG under contract no. Ri 242/12-1 and -2 and the DFG Graduiertenkolleg 'Physik und Technik von Beschleunigern
IFN-gamma Impairs Release of IL-8 by IL-1beta-stimulated A549 Lung Carcinoma Cells
Background Production of interferon (IFN)-gamma is key to efficient anti-tumor immunity. The present study was set out to investigate effects of IFNgamma on the release of the potent pro-angiogenic mediator IL-8 by human A549 lung carcinoma cells.
Methods A549 cells were cultured and stimulated with interleukin (IL)-1beta alone or in combination with IFNgamma. IL-8 production by these cells was analyzed with enzyme linked immuno sorbent assay (ELISA). mRNA-expression was analyzed by real-time PCR and RNase protection assay (RPA), respectively. Expression of inhibitor-kappaBalpha, cellular IL-8, and cyclooxygenase-2 was analyzed by Western blot analysis.
Results Here we demonstrate that IFNgamma efficiently reduced IL-8 secretion under the influence of IL-1beta. Surprisingly, real-time PCR analysis and RPA revealed that the inhibitory effect of IFNgamma on IL-8 was not associated with significant changes in mRNA levels. These observations concurred with lack of a modulatory activity of IFNgamma on IL-1beta-induced NF-kappaB activation as assessed by cellular IkappaB levels. Moreover, analysis of intracellular IL-8 suggests that IFNgamma modulated IL-8 secretion by action on the posttranslational level. In contrast to IL-8, IL-1beta-induced cyclooxygenase-2 expression and release of IL-6 were not affected by IFNgamma indicating that modulation of IL-1beta action by this cytokine displays specificity.
Conclusions Data presented herein agree with an angiostatic role of IFNgamma as seen in rodent models of solid tumors and suggest that increasing T helper type 1 (Th1)-like functions in lung cancer patients e.g. by local delivery of IFNgamma may mediate therapeutic benefit via mechanisms that potentially include modulation of pro-angiogenic IL-8
Brain-Computer Interface Games: Towards a Framework
The brain-computer interface (BCI) community started to consider games as potential applications while the games community started to consider BCI as a game controller. However, there is a discrepancy between the BCI games developed by the two communities. In this paper, we propose a preliminary BCI games framework that we constructed with respect to the research conducted in both the BCI and the games communities. Developers can situate their BCI games within this framework and benefit from the guidelines we provide and also extend the framework further
BNCI Horizon 2020 - Towards a Roadmap for Brain/Neural Computer Interaction
In this paper, we present BNCI Horizon 2020, an EU Coordination and Support Action (CSA) that will provide a roadmap for brain-computer interaction research for the next years, starting in 2013, and aiming at research efforts until 2020 and beyond. The project is a successor of the earlier EU-funded Future BNCI CSA that started in 2010 and produced a roadmap for a shorter time period. We present how we, a consortium of the main European BCI research groups as well as companies and end user representatives, expect to tackle the problem of designing a roadmap for BCI research. In this paper, we define the field with its recent developments, in particular by considering publications and EU-funded research projects, and we discuss how we plan to involve research groups, companies, and user groups in our effort to pave the way for useful and fruitful EU-funded BCI research for the next ten years
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