14 research outputs found
Building information modelling in construction: insights from collaboration and change management perspectives
© 2017 Informa UK Limited, trading as Taylor & Francis Group. A case study is used to obtain the experiences from a contractor and their subcontractors involved with constructing the landmark Perth Stadium, which required a building information model (BIM) to be delivered for the purpose of asset management. Insights about ‘how’ the adoption of a BIM influenced the practice of collaboration and change management within the project are obtained. It was revealed that having limited experience and knowledge to deliver a model for asset management often resulted the project team ‘muddling through a problem’. This was not necessarily due to a shortage of training, but a lack of BIM knowledge, which inadvertently influenced every day practice. The research presented builds on the extant body of works that have examined how the construction industry can effectively acquire the benefits of BIM for asset management. It also highlights the need to incorporate education and learning into a project’s BIM implementation strategy
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian (‘marsupial’) species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation