Evidence

Covers cases on exceptions to the hearsay rule, on facts that must be included in hypothetical questions and that may form the basis for an expert\u27s answer, and on judicial notice of the useful life structure according to the Internal Revenue Bulletin

One-loop corrections to gaugino (co-)annihilation into quarks in the MSSM

We present the full $\mathcal{O}(\alpha_s)$ supersymmetric QCD corrections for gaugino annihilation and co-annihilation into light and heavy quarks in the Minimal Supersymmetric Standard Model (MSSM). We demonstrate that these channels are phenomenologically relevant within the so-called phenomenological MSSM. We discuss selected technical details such as the dipole subtraction method in the case of light quarks and the treatment of the bottom quark mass and Yukawa coupling. Numerical results for the (co-)annihilation cross sections and the predicted neutralino relic density are presented. We show that the impact of including the radiative corrections on the cosmologically preferred region of the parameter space is larger than the current experimental uncertainty from Planck data.Comment: 19 pages, 9 figures. Matches version published in Phys.Rev.

Precision predictions for supersymmetric dark matter

The dark matter relic density has been measured by Planck and its predecessors with an accuracy of about 2%. We present theoretical calculations with the numerical program DM@NLO in next-to-leading order SUSY QCD and beyond, which allow to reach this precision for gaugino and squark (co-)annihilations, and use them to scan the phenomenological MSSM for viable regions, applying also low-energy, electroweak and hadron collider constraints.Comment: 6 pages, 1 table, 8 figures, proceedings of ICHEP 201

Strange Quark PDFs and Implications for Drell-Yan Boson Production at the LHC

Global analyses of Parton Distribution Functions (PDFs) have provided incisive constraints on the up and down quark components of the proton, but constraining the other flavor degrees of freedom is more challenging. Higher-order theory predictions and new data sets have contributed to recent improvements. Despite these efforts, the strange quark PDF has a sizable uncertainty, particularly in the small x region. We examine the constraints from experiment and theory, and investigate the impact of this uncertainty on LHC observables. In particular, we study W/Z production to see how the s-quark uncertainty propagates to these observables, and examine the extent to which precise measurements at the LHC can provide additional information on the proton flavor structure.Comment: 14 pages, 11 figures, added reference

Inequity Concerns in Social Networks

This paper explores the role of social integration on inequity concerns. Using a three-phase experimental protocol we 6rst elicit a social network from a group of undergraduate students in Economics; in the second phase, 169 of these subjects have to assign a 6xed amount of money to only one of two individuals and, then, in the third stage they decide how much they are willing to pay to "repair" the created inequality. Our experi- mental data indicate that standard measures of network theory, such as betweenness, out-degree and reciprocal degree, have a positive e\ua7ect on inequity concerns. These results suggest that (1) pro-sociality and social networks coevolve and (2) information on the social network structure, in which subjects are embedded is important to account for their behavior

Odnos strukture i aktivnosti u reaktivaciji tabunom fosforilirane ljudske acetilkolinesteraze bispiridinijevim para-aldoksimima

We investigated interactions of bispyridinium para-aldoximes N,N’-(propano)bis(4-hydroxyiminomethyl) pyridinium bromide (TMB-4), N,N’-(ethano)bis(4-hydroxyiminomethyl)pyridinium methanosulphonate (DMB-4), and N,N’-(methano)bis(4-hydroxyiminomethyl)pyridinium chloride (MMB-4) with human erythrocyte acetylcholinesterase phosphorylated by tabun. We analysed aldoxime conformations to determine the flexibility of aldoxime as an important feature for binding to the acetylcholinesterase active site. Tabun-inhibited human erythrocyte acetylcholinesterase was completely reactivated only by the most flexible bispyridinium aldoxime - TMB-4 with a propylene chain between two rings. Shorter linkers than propylene (methylene or ethylene) as in MMB-4 and DMB-4 did not allow appropriate orientation in the active site, and MMB-4 and DMB-4 were not efficient reactivators of tabun-phosphorylated acetylcholinesterase. Since aldoximes are also reversible inhibitors of native acetylcholinesterase, we determined dissociation constants and their protective index against acetylcholinesterase inactivation by tabun.Proučavali smo interakcije bispiridinijevih para-oksima N,N’-(propano)bis(4-hidroksiiminometil)piridinijeva bromida (TMB-4), N,N’-(etanano)bis(4-hidroksiiminometil)piridinijeva metanosulfonata (DMB-4) i N,N’- (metano)bis(4-hidroksiiminometil)piridinijeva klorida (MMB-4) s ljudskom eritrocitnom acetilkolinesterazom fosforiliranom tabunom. Da bismo odredili fleksibilnosti aldoksima, što je važna osobina kod njihova vezanja u aktivno mjesto acetilkolinesteraze, analizirali smo i konformacijske odlike aldoksima. Ljudska acetilkolinesteraza inhibirana tabunom bila je potpuno reaktivirana samo najfleksibilnijim bispiridinijevim aldoksimom – TMB-4. Aldoksimi MMB-4 i DMB-4 nisu bili efikasni reaktivatori acetilkolinesteraze fosforilirane tabunom jer je kod tih spojeva lanac koji povezuje dva prstena kraći od propilena (metilen u MMB-4 i etilen u DMB-4), što ne dopušta povoljnu orijentaciju tih aldoksima unutar aktivnog mjesta enzima. S obzirom na to da su aldoksimi i reverzibilni inhibitori nativne acetilkolinesteraze, odredili smo njihove disocijacijske konstante, kao i zaštitu acetilkolinesteraze od inhibiranja tabunom reverzibilnim vezanjem aldoksima

Insects Inhabiting the Burrows of the Ozark Pocket Gopher in Arkansas

Pocket gopher burrows provide a stable environment for a variety of inquilines; hence this mammal is regarded as a keystone species. Most of the arthropods inhabiting pocket gopher burrows are restricted to this microhabitat. As part of a planned state-wide biotic survey of insects inhabiting this unusual microhabitat, we have focused our initial sampling efforts on the Ozark pocket gopher (Geomys bursarius ozarkensis; Geomyidae). In 2004 and 2005, pitfall traps were established in pocket gopher burrows and in 2007 and 2008, nests and associated chambers were excavated. Retrieved samples contained scarab, histerid, and rove beetles, cave crickets and anthomyiid flies. The histerids consisted of five species, one of which is undescribed, and all of which are new state records. A total of five species of scarab beetles were collected and all of these represent new state records. Two species of cave crickets were collected; one appears to be undescribed, and the other is essentially a Great Plains species and represents a considerable range extension. Both crickets are new to Arkansas

Primjena tehnologije rekombinantne DNA za pripravke kolinesteraza kao antidota i detektora organofosfata

To develop new avenues for synthesizing novel antidotes for organophosphate poisoning and for detection of the organophosphates, we have turned to recombinant DNA methods to synthesize cholinesterases with unusual properties. For antidotal therapy we describe mutations of the native mouse and human enzymes that allow for enhanced rates of oxime reactivation. Such enzymes, when localized in the circulation, would enable the circulating cholinesterase to become a catalytic rather than simply a stoichiometric scavenger. Hence, “oxime-assisted catalysis” provides a means for scavenging the organophosphates in the circulation thereby minimizing their tissue penetration and toxicity. Accordingly, the oxime antidote or prophylactic agent has a dual action within the circulation and at the tissue level. Second, through a novel chemistry, termed freeze-frame, click chemistry, we have used organophosphate conjugates of acetylcholinesterase as templates for the synthesis of novel nucleophilic reactivating agents. Finally, acetylcholinesterase can be modified through cysteine substitution mutagenesis and attachment of fluorophores at the substitution positions. When linked at certain locations in the molecule, the attached fluorophore is sensitive to organophosphate conjugation with acetylcholinesterase, and thus the very target of insecticide or nerve agent action becomes a detection molecule for organophosphate exposure.Razvijajući novi pristup sintezi antidota pri otrovanju organofosfatima kao i njihovu detekciju, primijenili smo metode rekombinantne DNA za pripremu kolinesteraza s neuobičajenim svojstvima. Za antidotsku terapiju istražili smo mutacije prirodnih enzima miša i čovjeka koje povećavaju brzine reaktivacije oksimom. Takvi enzimi bi po unosu u cirkulaciju postali katalitički, a ne samo stehiometrijski odstranjivači organofosfata. Na taj način “oksimom potpomognuta kataliza” omogućava čišćenje organofosfata iz cirkulacije umanjujući prodiranje organofosfata u tkiva i njihovu toksičnost. Prema tome, oksim kao antidot ima dvojaku ulogu: u cirkulaciji i na razini tkiva. S druge strane, uporabom novog sintetskog pristupa u oblikovanju biološki aktivnih spojeva poznatog kao “klik kemija” diskretnih proteinskih konformacija, organofosforilirani konjugati acetilkolinesteraze služe kao kalup u sintezi novih nukleofilnih reaktivatora. Naposljetku, acetilkolinesteraza se može mutagenezom modificirati uvo|enjem cisteina na koje se mogu vezati fluorofori. Fluorofori uvedeni na određena mjesta u molekuli acetilkolinesteraze mijenjaju svoja fluorescentna svojstva pri konjugaciji organofosfata s enzimom koji na taj način od objekta djelovanja insekticida i živčanih bojnih otrova postaje molekula za detekciju izloženosti organofosfatima

FAPRI 2005 World Agricultural Outlook Briefing Book

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