A REVIEW ON SCOPES, METHODS AND RATIONALE OF INTEGRATIVE APPROACH IN SIDDHA MEDICINE WITH BIOMEDICINE

In India, according to WHO 2018 statistics, there were 63% of death occurred due to Non-communicable diseases (NCDs), in which Cardiovascular diseases were leading cause of death 27%, followed by Cancer 9%, Chronic respiratory disease 11%, Diabetes 3% and other NCDs 13%. This indicates that NCDs needs to become a priority in controlling and preventing. Therefore, the only effective intervention may be at controlling and preventing NCDs disease is Integrative Medicine. Integrative Medicine is a medical practice synthesizing Traditional medicine and Biomedicine preventive measures and treatment interventions. Autonomy of patients may end in no benefit out of their ignorance to select between the treatment options available in a country like India where Seven Recognized medical systems are available as a platter. Siddha system of medicine is one of the traditional medicines of India, practiced in the southern part of the country. This study aims at providing Health care system under one roof, in order to save public money, time and health as an existing model as co-location in Tamil Nadu. This can be achieved through assessing feasible areas of integration in the Siddha system of medicine with biomedicine. So the study deals with the utilization of Siddha system of medicine, scientific validation of Siddha medicines, Siddha medicine research undertaken by biomedical practitioners and some government policies supporting mainstreaming of Siddha

Prevalence of Microalbuminuria in relation to HbA1c among known Type2 Diabetic Patients in Puducherry population

ABSTRACT Diabetes mellitus is the commonest metabolic disorder and has a high prevalence in India. Diabetic nephropathy is characterized by proteinuria and is the leading cause of end stage renal disease. The prevalence of microalbuminuria predicts progression to diabetic nephropathy. This cross sectional study was carried out in the diabetic clinic at SVMCH and RC. Sixty known Type 2 diabetic patients with age 30-70 years of both genders were included in the study. Fasting, postprandial venous blood and morning urine sample was collected for analysis of blood glucose, HbA1c and microalbuminuria levels. Statistical analysis was done using SPSS version 17.0. Pearson correlation and Chi square test was applied to observe association of microalbuminuria with different parameters. P-value < 0.05 was considered as statistically significant. Our study showed that about 70% of the patients had HbA1c >7% and 48% of the patients had Microalbuminuria (≥30mg/day). Almost 45% of the patients with HbA1c >7% had Microalbuminuria (≥30mg/day) which indicates persistent increase in glycated haemoglobin and microalbuminuria may be considered as risk factor in diabetic nephropathy. Therefore, regular screening for microalbuminuria and HbA1c testing should be done in diabetic patients as an early marker of renal risk factor

A Study to Assess the Hormonal Profile of Polycystic Ovarian Syndrome in a Tertiary Care Hospital in Puducherry

ABSTRACT Polycystic ovarian syndrome (PCOS) is a complex, heterogeneous disorder characterized by oligomenorrhea, hirsutism, polycystic ovary with chronic anovulation and varying degrees of androgen excess.This cross sectional study was conducted at Department of Biochemistry, Sri Venkateshwaraa Medical College hospital and Research Institute, Pondicherry to assess the gynecological and thyroid profile in PCOS patients. Serum levels of FSH, LH, Prolactin, fT 3 , fT 4 and TSH levels were estimated in 50 PCOS patients compared with age matched controls. The results of our study showed that fifty percent of the patients were in the age group of 17 to 25 years and remaining were in the age group of 26 to 40 years. There was a statistically significant correlation between FSH and TSH (r=0.809 p<0.001) in the higher age group. It was concluded that PCOS diagnosed patients of higher age group, both gynecological profile and thyroid profile should be assessed to prevent the further complications

A Retrospective Study of Thyroid Disorders Among Women of Reproductive Age Group in Puducherry

ABSTRACT Thyroid disorders are the most prevalent endocrine disorders in our country. Thyroid dysfunction is implicated in a broad spectrum of reproductive disorders, ranging from abnormal sexual development to menstrual irregularities and infertility. This retrospective study was conducted using data retrieved from the register maintained in the Department of Biochemistry of our Institution between January 2011 and April 2014. Thyroid function profile and the related reproductive disorders were analysed . Out of 1192 patients screened, 63.8% were euthyroid, 27.5% were hypothyroid, 2.09% hyperthyroid and 6.54% of them had a mildly suppressed TSH. Amongst the hypothyroid patients, 6.7% of them were clinically hypothyroid and 20.8% subclinical hypothyroid. Among the hyperthyroid, the distribution was 1.5% clinical hyperthyroid and 0.5% subclinical hyperthyroid. The study revealed that hypothyroidism, especially subclinical was considerably increasing with the advancement of age. The prevalence of hypothyroidism seemed to be on the higher side among patients with infertility, PCOD and menstrual distrubances. Screening for thyroid diseases should be considered during routine evaluation in this particular group of women

Antiarthritic Activity of Kanthaga Parpam (KP) (Official Siddha Drug) in Complete Freund's Adjuvant (CFA) Induced Arthritic rats

ABSTRACT Periarthritis of the shoulder (frozen shoulder) is the most common problem among aged individuals. It is a well-defined condition with its phases of severe pain, increasing stiffness, and the gradual recovery of full movement of the shoulder. The present study evaluates the safety and anti-arthritic efficacy of herbomineral formulation kanthagaparpam (kp) (official siddha drug) in animal models. The anti-arthritic activity of kp (in doses of 25 mg/kg and 50 mg/kg of body wt.) Was evaluated using the complete freund's adjuvant (cfa) induced arthritis models. Diclofenac sodium (45 mg/kg body wt.) Was used as the standard drug in all the models. This study includes examination of the paws, haematological parameters, body weight changes, organ weight changes and paw withdrawal latency. The lesions were measured again on the 7th, 14th, and 21st days after injection of the adjuvant. The marked reduction of the arthritis score by kanthagaparpam as observed in our study indicates a possible immune suppressant effect .a significant reduction in the levels of the biomarkers of inflammation and autoimmune stimulation in the treated rats. Significant (p<0.05) decrease in mean paw edema level of treated group compare to control. Also significant (p<0.05) decrease in body weight of treated group compare to control. Significantly inhibit the progression of the arthritis in animal models. The present study reveals that the kanthaga parpam (kp) can be more beneficial in the treatment of periarthritis

Electrochemical synthesis of Au-Ni(OH)2-nanocomposite on glassy carbon electrode as highly active bifunctional electrocatalyst for oxygen evolution and oxygen reduction reactions

In this work, we demonstrated an electrochemical method to prepare Au-Ni(OH)2-nanocomposite on a glassy carbon substrate (Au-Ni(OH)2-NC/GCE). This modified nanocomposite showed high electrocatalytic activity towards oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) compared to similarly prepared Au free Ni(OH)2-NC/GCE. The above nanocomposite was prepared through two step processes; first gold‑nickel hexacyanoferrate nanocomposite film on GCE (Au-NiHCF-NC/GCE) was synthesized by single step electrochemical cycling approach. Later, the Au-NiHCF-NC/GCE was treated electrochemically in alkaline solution to produce Au-Ni(OH)2-NC/GCE. The as-formed Au-Ni(OH)2-NC/GCE was used as a bifunctional electrode to study the OER and ORR in alkaline solution. The resulting nanocomposite exhibits high electrocatalytic activity and fast electron transfer kinetics due to the synergic effect of the formation of more active β-Ni(OH)2 phase and Au nanoparticles (AuNPs) during the electrochemical cycling process

ULCER PROTECTIVE ACTIVITY OF GUNMATHI CHOORANAM ON PYLORIC LIGATED METHOD

The present investigation was undertaken is to explore the antiulcer activity of the Gunmathi Chooranam in rats by pyloric ligation method. The experimental parameters used were ulcer index, gastric pH parameters. The animals groups were divided in five controls, standard (Ranitidine 100 mg/kg) and Gunmathi Chooranam in 125, 250 and 500 mg/kg. The siddha formulation produced the significant action against the antiulcer group’s animal in all parameters. The Gunmathi Chooranam was found to be good antiulcer drug in siddha system