Mixed Solvents as Tools to Study the Structural Aspects of Cytochrome P450 in Solution at Sub-Zero Temperatures

Cytochromes P450 from various sources are known to have mixtures of different heme-iron electronic configurations, partly in thermodynamic equilibrium, reflecting different configurations of the protein. Organic solvents (such as ethylene glycol or glycerol) as well as temperature changes have a marked but reversible effect on the thermodynamic parameters of these equilibria in the fluid state. The solvent and temperature perturbation of the conformational or spin state equilibrium have been investigated on various redox states of cytochrome P450 in order to gain some insight · into the structure of the heme pocket

Eclipse in the Dark Years: Pick-up Flights, Routes of Resistance and the Free French

This article charts the importance of clandestine flights from Britain into occupied France during the Second World War as a route of resistance. These pick-up flights were coordinated from London and were an example of the inter-allied cooperation and Franco-British negotiation that took place between the BCRA, SIS, and SOE. The flights allowed General Charles de Gaulle to hold court with the leaders of resistance networks, smoothing problems on the route to a unified resistance council. Likewise, they allowed him to build bridges between vying factions in France and in London, drawing together the movements under his command and personalising the narrative of resistance. From busy London restaurants and family homes via secret flights to darkened fields in Occupied France, the route of these transfers shaped the character of resistance. This article draws out the personal interactions and connections that underpinned these networks and describes the enduring connections of this route of resistance, starting with the commemoration of Jean Moulin's crash landing at RAF Tangmere, the forward station for many of these flights

Biomaterials from protein solutions

International audienc

From cytoplasmic proteins to biomaterials

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La cryopreservation : un art en expansion qui sollicite la recherche

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Control of Cryotechniques in biology through sol-gel processings

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