25 research outputs found

    A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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    Anion-Dependent Switch in C–X Reductive Elimination Diastereoselectivity

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    [Image: see text] Reaction of a complex Pt organometallic species with electrophilic halogen sources in the presence of X(–) ligands changes the mechanism of reductive elimination from a concerted reductive coupling type to an S(N)2 type reductive elimination. In the absence of the added X(–) ligand the reductive elimination is stereoretentive; in its presence, the process is stereoinvertive. This selectivity hinges on the reactivity of a key five-coordinate Pt(IV) intermediate with the X(–) ligand
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