Obtaining quasi-static models using a frequency domain extraction methodology

© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.”This contribution illustrates how a realistic nonlinear quasi-static model for FET-type devices can be extracted using an original frequency domain extraction technique. An ideal ‘made-up’ device is built from the measured bias dependence of a GaN medium power device. This ideal device is excited by two ideal voltage sources and its response (drain current) is used to illustrate how the extraction procedure can separate conduction and displacement current components provided the total current spectrum (or, alternatively, waveform) and control voltages are known.This work has been supported by the Junta de Andalucía under Grant (TIC2012-1237). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

DC-18 GHz MMIC tapered distributed power amplifier

A DC-18 GHz MMIC tapered power distributed amplifier has been designed and simulated in GaAs technology. The amplifier has been designed according to the theory for power and efficiency maximization based on tapered drain lines. Small- and large-signal simulations have been carried out to evaluate the amplifier’s behaviour. Results suggest that it is possible to achieve a good performance in terms of output power and efficiency for a wide bandwidth.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Caracterización de modelos no-lineales casi-estáticos a partir de las formas de onda en régimen de gran señal

A method to extract the conduction and displacement components of nonlinear quasi-static current sources controlled by two variables is concisely described. The method is numerically tested by means of two different analytical examples of nonlinear current sources. The obtained results clearly illustrate its performance as well as its potentiality in the nonlinear modelling of FET/HEMT devicesEste trabajo ha sido financiado por la Junta de Andalucía por medio del proyecto TIC2012-1237. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Extracción de modelos casi-estáticos para dispositivos no-lineales a partir de medidas en el dominio de la frecuencia

In this contribution an extraction method already proposed by authors and suitable for FET-type devices that could be represented by a quasi-static model is illustrated. For the first time, the method is applied to a FET embedded in a parasitic shell and fed at each port with sources that include internal impedances. The main impact of adding these elements is that intrinsic voltages that control the nonlinear current and charge sources of the model to be extracted are not ideal monochromatic signals. The results show that the extraction method works with these more realistic control voltages at the expense of an important reduction of the range of control voltages with respect to the ideal case. The dependence of the results on the input power level is also assessed. Results demonstrate that the method is still valid under realistic conditions and it is ready to be applied to experimental results.Este trabajo ha sido parcialmente financiado por el Plan Propio de Investigación y Transferencia de la Universidad de Málaga-Andalucia Tech. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

Responsabilidad patrimonial tras la declaración de nulidad de las cláusulas suelo

One of the most relevant topical subjects in Spain, because of the number of adversely affected consumers and the importance and impact that it has had on the national and european legal field, has been the court decisions declaring terms to be unfair in general, and the declaration of nullity of ground clauses in mortgage-secured loans, in particular. After a succession of judgments of the Spanish Supreme Court that turned out to be not too fortunate, and that carried out a growing controversy, to finally be contradictied by the Court of Justice of the European Union, some weaknesses of the spanish legislative system has arisen, which have not benefited the spanish consumers, in contrast with the strong defence that the european body perfoms. In this present work, the causes that originated this conflict are studied, as well as the casuistry of complex situations to which this not correctly managed problem finally derived, to finally come to a real picture of the present situation so as to be able to come to some general conclusions and possible solutions to this problem, in the spanish legal system.Uno de los temas de mayor actualidad en España, por el número de consumidores perjudicados y por la trascendencia que a nivel nacional y europeo ha tenido en el ámbito jurídico, ha sido la declaración de cláusulas abusivas en general, y la declaración de nulidad de la cláusula suelo en el préstamo bancario con garantía hipotecaria, en particular. Tras una sucesión de sentencias del Tribunal Supremo español no demasiado afortunadas, que generaron una polémica creciente para, finalmente, ser contradichas por el Tribunal de Justicia de la Unión Europea, se han puesto de relieve ciertas deficiencias en el sistema legislativo español, que no han redundado en la protección del consumidor español, frente a la fuerte protección que lleva a cabo el Tribunal Europeo. En el presente trabajo se estudian las causas que originaron el conflicto, y la casuística de situaciones complejos a las que derivó el problema finalmente, para obtener así algunas conclusiones generales y soluciones al problema que este tipo de cláusulas entrañan en el sistema jurídico español

DocStories: @foto_historias_ The Photo Stories exhibition and intergenerational meetings

A partir de las fotografías recogidas en Instagram (@foto_historias_ ) se organizará una exposición fotográfica itinerante comisariada por el alumnado y se llevarán a cabo encuentros intergeneracionales entre estudiantes y escuelas de adultos.Unidad Deptal. de Biblioteconomía y DocumentaciónFac. de Ciencias de la InformaciónFALSEsubmitte

How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women

COVID-19 in hospitalized HIV-positive and HIV-negative patients : A matched study

CatedresObjectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization