12 research outputs found
Concise Total Synthesis and Stereochemical Revision of (+)-Naseseazines A and B: Regioselective Arylative Dimerization of Diketopiperazine Alkaloids
Concise and enantioselective total syntheses of (+)-naseseazines A and B are described. Our regioselective and directed dimerization of diketopiperazines provides their critical C3âC[2 over sp] linkages, an assembly with plausible biogenetic relevance. We revise the absolute stereochemistry of (+)-naseseazines A and B.National Institute of General Medical Sciences (U.S.) (GM089732)Amgen Inc.DuPont (Firm)American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowshi