Characteristics of Heart Rate Tracings in Preterm Fetus

We thank K. Shashok for translating the original manuscript into English.Background and Objectives: Prematurity is currently a serious public health issue worldwide, because of its high associated morbidity and mortality. Optimizing the management of these pregnancies is of high priority to improve perinatal outcomes. One tool frequently used to determine the degree of fetal wellbeing is cardiotocography (CTG). A review of the available literature on fetal heart rate (FHR) monitoring in preterm fetuses shows that studies are scarce, and the evidence thus far is unclear. The lack of reference standards for CTG patterns in preterm fetuses can lead to misinterpretation of the changes observed in electronic fetal monitoring (EFM). The aims of this narrative review were to summarize the most relevant concepts in the field of CTG interpretation in preterm fetuses, and to provide a practical approach that can be useful in clinical practice. Materials and Methods: A MEDLINE search was carried out, and the published articles thus identified were reviewed. Results: Compared to term fetuses, preterm fetuses have a slightly higher baseline FHR. Heart rate is faster in more immature fetuses, and variability is lower and increases in more mature fetuses. Transitory, low-amplitude decelerations are more frequent during the second trimester. Transitory increases in FHR are less frequent and become more frequent and increase in amplitude as gestational age increases. Conclusions: The main characteristics of FHR tracings changes as gestation proceeds, and it is of fundamental importance to be aware of these changes in order to correctly interpret CTG patterns in preterm fetuses

Automated Generation of Clinical Reports Using Sensing Technologies with Deep Learning Techniques

This study presents a pioneering approach that leverages advanced sensing technologies and data processing techniques to enhance the process of clinical documentation generation during medical consultations. By employing sophisticated sensors to capture and interpret various cues such as speech patterns, intonations, or pauses, the system aims to accurately perceive and understand patient–doctor interactions in real time. This sensing capability allows for the automation of transcription and summarization tasks, facilitating the creation of concise and informative clinical documents. Through the integration of automatic speech recognition sensors, spoken dialogue is seamlessly converted into text, enabling efficient data capture. Additionally, deep models such as Transformer models are utilized to extract and analyze crucial information from the dialogue, ensuring that the generated summaries encapsulate the essence of the consultations accurately. Despite encountering challenges during development, experimentation with these sensing technologies has yielded promising results. The system achieved a maximum ROUGE-1 metric score of 0.57, demonstrating its effectiveness in summarizing complex medical discussions. This sensor-based approach aims to alleviate the administrative burden on healthcare professionals by automating documentation tasks and safeguarding important patient information. Ultimately, by enhancing the efficiency and reliability of clinical documentation, this innovative method contributes to improving overall healthcare outcomes.We would like to thank “A way of making Europe” European Regional Development Fund (ERDF) and MCIN/AEI/10.13039/501100011033 for supporting this work under the “CHAN-TWIN” project (grant TED2021-130890B-C21. HORIZON-MSCA-2021-SE-0 action number: 101086387, REMARKABLE, Rural Environmental Monitoring via ultra wide-ARea networKs And distriButed federated Learning; CIAICO/2022/132 Consolidated group project “AI4Health” funded by the Valencian government and International Center for Aging Research ICAR funded project “IASISTEM.” This work has also been supported by a Valencian government grant for PhD studies, CIACIF/2022/175 and a research initiation grant from the University of Alicante, AII23-12

The influence of a badminton competition with two matches in a day on muscle damage and physical performance in elite junior badminton players

[EN] To investigate the effects of a badminton competition with 2 matches in a day on hip strength and range of motion (ROM) and exercise-induced muscle damage in elite junior badminton players. Twenty players (age: 17±0.8 years; body mass: 62.9±6.5 kg, height: 173.8±8.9 cm) participated in this study. Passive hip internal (IR) and external rotation (ER), abduction (ABD) and adduction (ADD) hip ROM, isometric hip ADD and ABD muscle strength, countermovement vertical jump (CMJ) height and blood creatine kinase concentration (CK) were measured before and after a badminton competition during an international tournament. Blood samples were collected 24 h after the end of the last match. Compared to baseline values, hip IR and ER ROM were significantly decreased at post-competition in the dominant (IR=-9.0%; p=0.007 and ER=-15.2%; p=0.002) and non-dominant limbs (IR=-9.08%; p=0.004 and ER=-19.4%; p<0.001). In contrast, hip ADD (13.5%; p<0.001) and ABD (14.6%; p<0.001) strength increased significantly after the competition in the dominant limb and ABD strength increased significantly in the non-dominant limb (9.2%; p=0.001). From baseline values, CK increased after the competition (430.1%) and values remained elevated over baseline values 24 h later (160.4%). Although hip muscle strength increased, a badminton competition with two consecutive matches reduced hip ROM and increased blood CK concentration. This study suggests the necessity of investigating recovery strategies after a badminton competition to return hip ROM to basal values before the next day of the competition.SIThe authors would like to express their gratitude to badminton play- ers who participated in the study.Funding received from Badminton World Federation (BWF), Kuala Lumpur (Malaysia

Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players.

Previous investigations have found that several genes may be associated with the interindividual variability to the ergogenic response to caffeine. The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (−163C  > A, rs762551; characterized such as “fast” (AA genotype) and “slow” caffeine metabolizers (C-carriers)) and ADORA2A (1976T  > C; rs5751876; characterized by “high” (TT genotype) or “low” sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players. Thirty-one professional handball players (sixteen men and fifteen women; daily caffeine intake = 60 ± 25 mg·d−1) ingested 3 mg·kg−1·body mass (bm) of caffeine or placebo 60 min before undergoing a battery of performance tests consisting of a countermovement jump (CMJ), a sprint test, an agility test, an isometric handgrip test, and several ball throws. Afterwards, the handball players performed a simulated handball match (2 × 20 min) while movements were recorded using inertial units. Saliva samples were analyzed to determine the genotype of each player for the −163C  > A polymorphism in the CYP1A2 gene (rs762551) and for the 1976T  > C polymorphism in the ADORA2A gene (rs5751876). In the CYP1A2, C-allele carriers (54.8%) were compared to AA homozygotes (45.2%). In the ADORA2A, C-allele carriers (80.6%) were compared to TT homozygotes (19.4%). There was only a genotype x treatment interaction for the ball throwing from 7 m (p = 0.037) indicating that the ergogenic effect of caffeine on this test was higher in CYP1A2 AA homozygotes than in C-allele carriers. In the remaining variables, there were no genotype x treatment interactions for CYP1A2 or for ADORA2A. As a whole group, caffeine increased CMJ height, performance in the sprint velocity test, and ball throwing velocity from 9 m (2.8–4.3%, p = 0.001–0.022, effect size = 0.17–0.31). Thus, pre-exercise caffeine supplementation at a dose of 3 mg·kg−1·bm can be considered as an ergogenic strategy to enhance some neuromuscular aspects of handball performance in professional handball players with low daily caffeine consumption. However, the ergogenic response to acute caffeine intake was not modulated by CYP1A2 or ADORA2A genotypes.post-print617 K

Flow disposicional en salvamento deportivo : una aproximación desde la teoría de la autodeterminación

This study analyzed the relationships between perceived motivational climates, psychological mediators, selfdetermined motivation and dispositional flow in lifesaving sport. The study variables also examined differences according to gender, age and daily practice time. A total of 283 athletes with a mean age of 17.27 years (SD = 3.36) who completed the Perceived Motivational Climate in Sport Questionnaire-2 (PMCSQ-2), the Motivational Mediators in Sport Scale (EMMD), the Sport Motivational Scale (SMS) and the Dispositional Flow Scale (DFS) participated in the study. The results revealed that perceived task and ego-involving motivational climates, perceived competence and autonomy, and selfdetermined motivation positively predicted dispositional flow with 50% of the variance explained. Men reported higher scores in autonomy, competence and dispositional flow than women did. Older athletes displayed a higher level of perceived autonomy than younger ones. The results are discussed in connection with the motivational factors important to improving dispositional flow

Age and sex-related upper body performance differences in competitive young tennis players

[EN] Objective The aims of this study were to analyze the shoulder functional profile of young male and female tennis players and to establish the relationship among physical variables and serve speed. Methods A total of 128 Spanish tennis players (Under-13 (n = 32/32 males/females) and Under-15 (n = 36/28 males/females), were tested during National training camps. Tests included passive shoulder range of motion (ROM) for both internal (IR) and external rotation (ER) and isometric strength (i.e., IR and ER) of the dominant/non-dominant shoulders, medicine ball throws (MBT), and serve speed. Age and sex pairwise comparisons were carried using the Hedges’ g index (dg). Results Results showed age and sex effects on serve speed and all MBT, with males showing greater changes (1.51<=dg<=1.98) with age than females (0.92<=dg<=1.35; p<0.05). U15 males showed higher (p<0.05) absolute shoulder IR and ER strength than U13, with only significant differences between males and females in the U15. Regarding ROM, U15 males showed a decreased IR ROM compared to U13 (dg = -0.84; p<0.05) and higher significant IR bilateral deficit (dg = 0.51; p<0.05). The distances obtained in the different MBT were the variables more correlated to serve speed. Conclusion The present results suggest that shoulder strength, medicine ball throws and serve speed increased along with age in young elite tennis players of both sexes. However, a decreasedS

Analysis of longitudinal metabolomic data using multivariate curve resolution-alternating least squares and pathway analysis

Extraction of meaningful biological information from longitudinal metabolomic studies is a major challenge and typically involves multivariate analysis and dimensional reduction methods for data visualization such as Principal Component Analysis or Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS). Besides, a variety of computational tools have been developed to identify changes in metabolic pathways including functional analysis and pathway analysis. In this work, the joint analysis of results from MCR-ALS and metabolic pathway analysis is proposed to facilitate the interpretation of dynamic changes in longitudinal metabolomic data. The strategy is based on the use of MCR-ALS to remove unstructured random variation in the raw data, thus facilitating the interpretation of dynamic changes observed by metabolic pathway analysis over time. A simulated data set representing dynamic longitudinal changes in the intensities of a subset of metabolites from three metabolic pathways was initially used to test the applicability of MCR-ALS to support pathway analysis for detecting pathway perturbations. Then, the strategy is applied to real data acquired for the analysis of changes during CD8+ T cell activation. Results obtained show that MCR-ALS facilitates the interpretation of longitudinal metabolomic profiles in multivariate data sets by identifying metabolic pathways associated with each detected dynamic component

The influence of a badminton competition with two matches in a day on muscle damage and physical performance in elite junior badminton players

To investigate the effects of a badminton competition with 2 matches in a day on hip strength and range of motion (ROM) and exercise-induced muscle damage in elite junior badminton players. Twenty players (age: 17±0.8 years; body mass: 62.9±6.5 kg, height: 173.8±8.9 cm) participated in this study. Passive hip internal (IR) and external rotation (ER), abduction (ABD) and adduction (ADD) hip ROM, isometric hip ADD and ABD muscle strength, countermovement vertical jump (CMJ) height and blood creatine kinase concentration (CK) were measured before and after a badminton competition during an international tournament. Blood samples were collected 24 h after the end of the last match. Compared to baseline values, hip IR and ER ROM were significantly decreased at post-competition in the dominant (IR=-9.0%; p=0.007 and ER=-15.2%; p=0.002) and non-dominant limbs (IR=-9.08%; p=0.004 and ER=-19.4%; p<0.001). In contrast, hip ADD (13.5%; p<0.001) and ABD (14.6%; p<0.001) strength increased significantly after the competition in the dominant limb and ABD strength increased significantly in the non-dominant limb (9.2%; p=0.001). From baseline values, CK increased after the competition (430.1%) and values remained elevated over baseline values 24 h later (160.4%). Although hip muscle strength increased, a badminton competition with two consecutive matches reduced hip ROM and increased blood CK concentration. This study suggests the necessity of investigating recovery strategies after a badminton competition to return hip ROM to basal values before the next day of the competition.Funding received from Badminton World Federation (BWF), Kuala Lumpur (Malaysia)

Estimación de Microplásticos en la Atmosfera Utilizando Dinamica de Sistemas

System dynamics is used to address the problem of microplastics in the atmosphere and its effects on the environment. This approach involves creating a system that takes into account interactions between atmospheric deposition, moss retention and impacts on the moor. Factors such as the absorption of microplastics and the concentration of these particles in the atmosphere are identified. The findings cover several scenarios, ranging from initial conditions to improvements in retention capacity, moor sensitivity, dispersion of microplastics and achieving a 90% absorption rate by moss. These results underline the vital role in mitigating air pollution. The use of system dynamics is demonstrated as an effective instrument to understand the intricate dynamics between atmospheric deposition and its accumulation. By modeling essential variables and relationships, this holistic approach not only helps determine the quantity and composition of microplastics, but also allows projecting possible long-term scenarios. This combination of mosses and system dynamics is established as a reliable strategy to address the environmental impact of microplastics by examining atmospheric deposition.La dinámica de sistemas se utiliza para abordar el problema de los microplásticos en la atmósfera y sus efectos para el medio ambiente. Este enfoque implica la creación de un sistema que tenga en cuenta interacciones entre la deposición atmosférica, la retención de musgo y los impactos en el páramo. Se identifican factores como la absorcion de microplásticos y la concentración de estas partículas en la atmósfera. Los hallazgos abarcan varios escenarios, que van desde las condiciones iniciales hasta mejoras en la capacidad de retención, la sensibilidad de los páramos, la dispersión de microplásticos y la consecución de una tasa de absorción del 90% por parte del musgo. Estos resultados subrayan el papel vital en la mitigación de la contaminación del aire. La utilización de la dinámica de sistemas se demuestra como un instrumento eficaz para comprender la intrincada dinámica entre la deposición atmosférica y su acumulación. Al modelar variables y relaciones esenciales, este enfoque holístico no solo ayuda a determinar la cantidad y composición de los microplásticos, sino que también permite proyectar posibles escenarios a largo plazo. Esta combinación de musgos y dinámica de sistemas se establece como una estrategia confiable para abordar el impacto ambiental de los microplásticos mediante el examen de la deposición atmosférica.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp

A note on the off-diagonal Muckenhoupt-Wheeden conjecture

We obtain the off-diagonal Muckenhoupt-Wheeden conjec-ture for Calder´on-Zygmund operators. Namely, given 1 < p < q < ∞ and a pair of weights (u, v), if the Hardy-Littlewood maximal functionsatisfies the following two weight inequalities: M : Lp(v) → Lq(u) and M : Lq´(u1−q´) → Lp´(v1−p´), then any Calderón-Zygmund operator Tand its associated truncatedmaximal operator T⋆ are bounded from Lp(v) to Lq(u). Additionally, as-suming only the second estimate for Mthen Tand T* map continuouslyLp(v) into Lq,∞(u). We also consider the case of generalized Haar shiftoperators and show that their off-diagonal two weight estimates are gov-erned by the corresponding estimates for the dyadic Hardy-Littlewoodmaximal function