Synthesis and Characterization of Benzoxazinone Derivatives

The present work reports synthesis and characterization of different benzoxazinone derivatives. 2-methyl-7-nitro-4H-3,1-benzoxazin-4-one was prepared by refluxing 4- nitroanthranilic acid with acid anhydride. Derivatives of 2-methyl-7-nitro-4H-3,1-benzoxazin-4-one were synthesized by condensation of it with different anilines. Elemental analysis and NMR spectral studies were used to confirm the formation of compounds

Synthesis and Characterization of Chalcones and Pyrazolines derived from Substituted Aryl ether

Few novel chalcones were synthesised by treating 4-fluoro-3-phenoxy benzaldehyde with different substituted ketones and characterised using 1H NMR and mass spectrometry. The chalcones synthesised were further treated with hydrazine hydrate to get corresponding pyrazolines. The newly synthesised pyrazolines were characterised by 1H NMR and mass spectrometry

Synthesis, structural elucidation and larvicidal activity of novel arylhydrazones

The present study focuses on a series of novel hydrazones of 2- [3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carbohydrazide (5a-l) for their larvicidal activity against Anopheles arabiensis. The synthesis of the title compounds was achieved by the conventional reflux method, and structures of the novel compounds were ascertained by FT-IR, NMR (1H &13C), LC-MS, and elemental analysis. Compound (5l) was studied by single crystal X-ray diffraction for intra and intermolecular interactions. Title compounds (E)-2-(3-cyano-4-isobutoxyphenyl)-N'-(4-fluoro-3-phenoxybenzylidene)-4-methylthiazole-5-carbohydrazide (5a) and (E)-N'-(4-Chlorobenzylidene)-2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carbohydrazide (5g) emerged as promising larvicidal agents against Anopheles arabiensis.Fil: Nefisath, P.. Mangalore University; India. Sri Dharmasthala Manjunatheshwara College (autonomous); IndiaFil: Dasappa, Jagadeesh Prasad. Mangalore University; IndiaFil: Haripriya, B.. Indian Institute Of Science Education And Research Bhopal; IndiaFil: Chopra, Deepak. Indian Institute Of Science Education And Research Bhopal; IndiaFil: Venugopala, Katharigatta N.. Durban University Of Technology; Sudáfrica. King Faisal University; Arabia SauditaFil: Deb, Pran Kishore. Philadelphia University Jordan; JordaniaFil: Gleiser, Raquel M.. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Mohanlall, Viresh. Durban University Of Technology; SudáfricaFil: Maharaj, Rajendra. South African Medical Research Council; SudáfricaFil: Shashiprabha, S.. Sri Dharmasthala Manjunatheshwara College (autonomous); IndiaFil: Poojary, Vishwanatha. Sri Dharmasthala Manjunatheshwara College (autonomous); Indi

Synthesis, characterization and larvicidal activity of novel benzylidene derivatives of fenobam and its thio analogues with crystal insight

A series of novel benzylidene derivatives of fenobam (6a-p) and its thio analogues (7a-f) were synthesized and evaluated for their larvicidal activity against the malaria vector Anopheles arabiensis. The newly synthesized compounds were characterized by FT-IR, NMR (1H and 13C), LC-MS, spectral studies, and elemental analysis. Selected compounds from this series were further studied by the single-crystal X-ray method to establish the molecular conformation and investigate the presence of various intra- and intermolecular interactions. The larvicidal activity of these test compounds (6a-p and 7a-f) was analyzed following WHO guidelines. Compounds 1-(4-fluorophenyl)-3-{(2E,5Z)-1-methyl-5-[(5-methylfuran-2-yl)methylidene]-4-oxoimidazolidin-2-ylidene}thiourea (7e), 1-(4-fluorophenyl)-3-[(2E,5Z)-1-methyl-5-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-4-oxoimidazolidin-2-ylidene]thiourea (7f) and 1-(4-fluorophenyl)-3-[(2E,5Z)-1-methyl-5-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-4-oxoimidazolidin-2-ylidene]urea (6l) emerged as promising larvicidal agents exhibiting 85 to 92% larval mortality.Fil: Nefisath, P.. Sri Dharmasthala Manjunatheshwara College (autonomous); India. Mangalore University; IndiaFil: Prasad Dasappa, Jagadeesh. Mangalore University; IndiaFil: Haripriya, B.. Indian Institute Of Science Education And Research Bhopal; IndiaFil: Chopra, Deepak. Indian Institute Of Science Education And Research Bhopal; IndiaFil: Venugopala, Katharigatta N.. King Faisal University; Arabia Saudita. Durban University Of Technology; SudáfricaFil: Deb, Pran Kishore. Philadelphia University Jordan; JordaniaFil: Gleiser, Raquel M.. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinar de Biología Vegetal (P). Grupo Vinculado Centro de Relevamiento y Evaluación de Recursos Agrícolas y Naturales; ArgentinaFil: Mohanlall, Viresh. Durban University Of Technology; SudáfricaFil: Maharaj, Rajendra. South African Medical Research Council; SudáfricaFil: Shashiprabha, S.. Sri Dharmasthala Manjunatheshwara College (autonomous); IndiaFil: Poojary, Vishwanatha. Sri Dharmasthala Manjunatheshwara College (autonomous); Indi