LONG-TERM SURVIVORS OF GLIOBLASTOMA

9th Meeting of European-Association-of-NeuroOncology -- SEP 16-19, 2010 -- Maastricht, NETHERLANDSWOS: 000281184800183European Assoc NeuroOnco

Is tattoo in the operative field a disadvantage in posterior thoracolumbar surgery?

Objective: Tattooing has become more popular, especially in Western culture. We aimed to analyze the impacts of the presence of tattoos in the operative field for posterior thoracolumbar surgery. Methodology: This study was performed using data extracted from the medical files of 15 patients who underwent posterior thoracolumbar surgery between April 2013 and May 2020 in the neurosurgery department of our tertiary care center. Therapeutic, clinical, and cosmetic outcomes after surgery necessitating incision on the tattoo are presented together with a brief discussion of the current literature. Results: Our series consisted of nine women and six men with an average age of 31.03 (range, 17-45) years. The duration of follow-up was 52 (range, 6-90) months. Ten patients underwent posterior spinal stabilization, and a simple discectomy was performed on five patients. The therapeutic outcomes and clinical improvement were satisfactory in all patients. No complications attributed to the presence of tattoos were detected in any patients. Conclusion: Posterior thoracolumbar surgery usually necessitates a midline incision that may unavoidably result in the deformation of a tattoo. Our results yielded that therapeutic and cosmetic results in patients with tattoos in the operative field were acceptable in the vast majority of cases after posterior thoracolumbar surgery. © 2022 AVES. All rights reserved

Effect of decompressive craniectomy for malignant middle cerebral artery infarction especially in elderly patients: a Single center experience for 113 patients

1st Congress of the European-Academy-of-Neurology -- JUN 20-23, 2015 -- Berlin, GERMANYWOS: 000364239000216European Acad Neuro

R132H mutation in IDH1 gene is associated with increased tumor HIF1-alpha and serum VEGF levels in primary glioblastoma multiforme

PubMed ID: 28667042Goals. Glioblastoma multiforme (GBM) is the most common form of primary brain tumors. Although mutations in isocitrate dehydrogenase-1 (IDH1) have been identified in a number of cancers, their role in tumor development has not been fully elucidated. In this study, we aimed to investigate the association between IDH1 mutations, tumor tissue HIF-1 alpha, and serum VEGF levels in patients with primary GBM for the first time. Methods. 32 patients (mean age, years: 58±14.0) diagnosed with primary glioblastoma multiforme were screened for IDH1 mutations (R132H, R132S, R132C and R132L) by direct sequencing. Serum VEGF and tumor tissue HIF1-alpha levels were measured by enzyme-linked immunosorbent assay. Associations between categoric variables were determined using chi-square tests. Differences between two groups were compared with t test for continuous variables. Results. Six percent of patients were found to be heterozygous for R132H mutation. Tumor HIF1-alpha and serum VEGF levels were found to be significantly increased in IDH1-mutated tumor tissues (p < 0.0001 and p=0.0454, respectively). Conclusion. Our results suggest that mutated IDH1 may contribute to carcinogenesis via induction of HIF-1 alpha pathway in primary GBM. © 2017 by the Association of Clinical Scientists, Inc

Vancomycin versus teicoplanin in the therapy of experimental methicillin-resistant Staphylococcus aureus (MRSA) meningitis

15th European Congress of Clinical Microbiology and Infectious Diseases -- APR 02-05, 2005 -- Copenhagen, DENMARKWOS: 000233421000010PubMed ID: 16221540The aim of this study was to compare the antibacterial activity of teicoplanin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis using a rabbit meningitis model. The MRSA strain ATCC 43300 was used to infect the rabbits. The vancomycin group received 20 mg/kg vancomycin every 12 h (q12h), the teicoplanin group received 6 mg/kg teicoplanin q12h and the control group did not receive any treatment. Drug levels were measured using a bioassay technique. Bacterial counts in the treatment groups were significantly lower (P 0.05). These data suggest that the antibacterial activity of vancomycin and teicoplanin are similar in experimental MRSA meningitis of rabbits. (C) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved