Colostrum immunoglobulins and oxidative capacity may be affected by infant sex and maternal age and parity

Conclusion: In conclusion, sex-based hormonal changes in mothers during pregnancy may be associated with the different colostral immunoglobulin levels for male and female infants

Comparison of MED 12 gene mutation and microRNA-124 expression in leiomyoma and myometrium of Turkish patients

Objectives: It is believed that there are still unclear areas in the formation mechanism of leiomyomas. In our study, itwas aimed to investigate the formation mechanisms of leiomyomas due to local MED 12 gene exon 2 mutation and localmicroRNA-124 expression in a Turkish population.Material and methods: Thirty patients who underwent hysterectomy for leiomyoma uteri at Gaziantep University betweenJanuary 2013 and January 2016 were included in our study. In the pathology specimens of these patients, the patient’smyometrium tissue and her own leiomyoma tissue were analysed via quantitative Realtime PCR in association with MED12 exon 2 mutation and microRNA-124 expression.Results: The average age of the 30 patients included in our study is 46.67 ± 5.42 and 13 patients had single leiomyoma;17 patients had more than one leiomyoma. There were significantly higher c.130G> T (p.G44C) mutation and c.131G> A(p.G44A) mutation of MED 12 gene exon in leiomyoma tissues than healthy myometrium tissues of same patients. Therewas a 3.7-fold decrease in the expression of microRNA-124 in leiomyoma tissues compared to intact eutopic myometriumtissues, but this difference was not statistically significant.Conclusions: In recent studies, it has been suggested that MED 12 gene may play an active role in the formation offibroids. MED12 and β-catenin / Wnt pathway were emphasized, and alternative genetic pathways are sought in fibroidformation. Also, tumour suppressor and oncogenesis effects of microRNAs have been demonstrated in many differentstudies. Since it is involved in the Wnt pathway, microRNA-124 has been blamed by some previous studies for the formationof fibroids. This study demonstrates that MED12 exon 2 mutations and probably microRNA-124 gene expressions mightcontribute to uterine leiomyoma pathology