Role of lymphadenectomy in disease-free and overall survival on low risk endometrium cancer patients

Objectives: Evaluation of the effect of lymphadenectomy in disease-free and overall survival on the low risk corpus cancer. Material and methods: Between 1994 and 2012, a total of 257 patients with endometrioid type, grade 1 or 2, myometrial invasion < 1/2, no intraoperative evidence of macroscopic extrauterine spread was treated surgically. Pelvic lymphadenec­tomy was performed in 184 cases, and not performed in 73 cases. Results: There was no difference between two groups about tumor sizes. Also lymphovascular space invasion and histo­logic grade of two groups were similar. Omission of LA did not worsen DFS and OS in early stage low risk corpus cancer. Conclusions: Patients who have low risk corpus cancer, can be treated optimally with hysterectomy only

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

Objectives: The aim of our study is to determine whether first-trimester neutrophil-to-lymphocyte ratio (NLR) and plate­let-to-lymphocyte ratio (PLR) would be useful as new predictors of subsequent preeclampsia. Material and methods: Medical records of women with preeclampsia and healthy controls from a tertiary referral center were retrospectively evaluated. The two groups were compared in terms of clinical characteristics and first-trimester levels of hemoglobin, leukocyte, neutrophil, lymphocyte, platelet, NLR and PLR. Receiver operating characteristic curve (ROC) analysis was performed to identify the optimal NLR and PLR levels predicting preeclampsia. Results: Neutrophil (p < 0.001), platelet (p < 0.001), NLR (p < 0.001) and PLR (p < 0.001) levels were significantly elevated, whereas hemoglobin concentration (p = 0.003) was significantly lower in the group with preeclampsia as compared to the control group. On multivariate regression analysis, NLR (OR 1.43; 95% CI 1.21–1.76; p = 0.005) and PLR (OR 1.38; 95% CI 1.15–1.63; p = 0.008) were the most powerful predictive variables. The area under the ROC was 0.716 and 0.705 for NLR and PLR, respectively. The cut-off values of NLR ≥ 3.08 and PLR ≥ 126.8 predicted preeclampsia with the sensitivity of 74.6% and 71.8% and specificity of 70.1% and 72.4%, respectively. Conclusions: High NLR and PLR during the first trimester are independent predictors of subsequent preeclampsia

A new lab-on-chip transmitter for the detection of proteins using RNA aptamers

A new RNA aptamer based affinity biosensor for CReactive Protein (CRP), a risk marker for cardiovascular disease was developed using interdigitated capacitor (IDC), integrated in Voltage Controlled Oscillator (VCO) and output signal is amplified using Single Stage Power Amplifier (PA) for transmitting signal to receiver at Industrial, Scientific and Medical (ISM) band. The Lab-on-Chip transmitter design includes IDC, VCO and PA. The design was implemented in IHP 0.25μm SiGe BiCMOS process; post-CMOS process was utilized to increase the sensitivity of biosensor. The CRP was incubated between or on interdigitated electrodes and the changes in capacitance of IDC occurred. In blank measurements, the oscillation frequency was 2.464GHz whereas after RNA aptamers were immobilized on open aluminum areas of IDC and followed by binding reaction processed with 500pg/ml CRP solution, the capacitance shifted to 2.428GHz. Phase noise is changed from -114.3dBc/Hz to -116.5dBc/Hz

A 6-bit vector-sum phase shifter with a decoder based control circuit for x-band phased-arrays

This letter presents a 6-bit vector-sum phase shifter with a novel control circuitry for X-band phased-arrays using a 0.25-m SiGe BiCMOS technology. A balanced active balun and highly accurate I/Q network are employed to generate the reference in-phase and quadrature vectors. The desired phase is synthesized by modulating and summing the generated reference vectors using current steering VGAs that are controlled by a decoder based control circuit. The phase shifter resulted in a measured RMS phase error <2.8 between 9.6-11.7 GHz and <5.6 between 8.2-12 GHz, achieving 6-bit phase resolution. The chip size is 1.870.88 mm2, excluding pads. To the best of authors’ knowledge, this is the first demonstration of a digitally controlled 6-bit vector-sum phase shifter for X-band

A wideband low noise SiGe medium power amplifier for x-band phased array applications

This paper presents a Medium Power Amplifier (MPA) for X-Band Phased Array RADAR applications in 0.25 mu m SiGe technology. The MPA is designed such that it achieves high output power and low noise simultaneously that enables its use in Transmitter/ Receiver (T/R) core module as a Low Noise Amplifier (LNA). The MPA achieves 23.6dB peak gain and 17.3dB maximum output power at 10GHz with a power consumption of 190mW. Its input and output is matched in a 7 GHz of bandwidth, while its mean Noise Figure (NF) is about 3dB throughout the defined bandwidth. According to authors' knowledge, this work presents state-of-the-art wideband MPA performances in literature, with 7GHz of operational bandwidth and 17.3dBm output power

A wideband high isolation CMOS T/R switch for x-band phased array radar systems

This paper presents an SPDT switch which is designed to operate at 8-12 GHz frequency range (X-Band), as a sub module of the front end circuit of a phased array radar. The switch distinguishes itself from its counterparts with its larger frequency range and higher isolation that is uniformly distributed over its bandwidth. It is fabricated using 0.25 mu m SiGe BiCMOS technology of IHP Microelectronics (Germany). As a new technique, shunt inductors are placed next to shunt transistors in order to improve trade-off between insertion loss and isolation. It has isolation higher than 30 dB in entire band, input referred 1dB compression point is 27.6 dBm, insertion loss is between 2.7-4.1 dB, input and output referred return losses are better than 11 dB in the frequency range of 8-12 Gliz