Comparison of intravaginal electrical stimulation and trospium hydrochloride in women with overactive bladder syndrome: a randomized controlled study

WOS: 000276174500006PubMed ID: 20212061Objective: To compare the effects of trospium hydrochloride and electrical stimulation on urodynamic parameters, bladder diary, quality of life and psychological symptoms in female patients with overactive bladder syndrome. Design: Prospective, randomized controlled trial. Setting: Department of Physical Medicine and Rehabilitation, University Hospital. Subjects: Thirty-five patients were divided into either trospium chloride (Group 1) or intravaginal electrical stimulation therapy (Group 2). Main outcome measures: All patients were assessed at the beginning of the treatment, at weeks 6 (end of treatment), 10 and 18 according to urodynamic parameters, voiding diary parameters, severity of urgency (visual analogue scale, VAS), the Incontinence Impact Questionnaire Short Form (IIQ-7), and the Beck Depression Inventory. Results: Statistically significant improvements were observed in both groups according to some urodynamic parameters, voiding diary parameters, VAS urgency severity, Incontinence Impact Questionnaire Short Form and Beck Depression Inventory scores at the end of the treatment (P0.05). Conclusion: No difference was detected between trospium hydrochloride and intravaginal electrical stimulation in the treatment of female overactive bladder syndrome. Discontinuation of both treatments caused deterioration in most of the objective and subjective symptoms of overactive bladder syndrome

Infective Endocarditis Presenting as Polymyalgia Rheumatica: Case Report

WOS: 000295972800010Infective endocarditis is a bacterial infection of the cardiac valves and endocardium with a high level of mortality and morbidity. Due to such high mortality and morbidity risks, early and accurate diagnosis bears great importance. Accordingly, for prevention of wrong or delayed diagnosis and treatment, it is important to know and be aware of diseases that can be mimicked by infective endocarditis and to keep such diseases in mind in the assessment and evaluation of the patient. In patients suffering from infective endocarditis, the disease may be accompanied by rheumatological symptoms and manifestations such as myalgia, arthralgia and arthritis. A review of the existing medical literature reveals a few cases of infective endocarditis mimicking polymyalgia rheumatica. In this article, we present a 64-year-old male case of infective endocarditis mimicking polymyalgia rheumatica without any known predisposing factor for infective endocarditis

Experimental Repair of Rabbit Segmental Bone Defects by Using Autologous Bone Marrow and Electrical Stimulation

WOS: 000277987300026Objective: In this study, we have aimed to investigate the potential role of autologous bone marrow cell injection and muscular electrical stimulation as a separate and concomitant application on bone healing in experimental rabbit ulnar segmental bone defect model. Material and Methods: Forty New-Zealand rabbits, all over three months of age and weighing between 2500 and 3500 grams were divided into four groups. Four groups of rabbits were the control group (I), electrical stimulation group (II), bone marrow cells injection group (III) and bone marrow cells injection with electrical stimulation group (IV). Bone defect healing was evaluated radiologically according to the modified Lane and Sandhu scoring system and at the end of the sixth week, rabbits were sacrificed and their forearms were sampled for histopathological investigation. Results: When one-to-one comparison between all groups was performed, defect healing was found to be better in Groups II, III, and IV compared to Group I based on the radiological and histopathological parameters evaluated. This evaluation revealed that the healing was better in groups treated with bone marrow cell injection with or without electrical stimulation as well as in group treated with electrical stimulation compared to the control group with no treatment. Conclusion: Autologous bone marrow cells with or without electrical stimulation, would be used in healing of segmental bone defect with an adequate efficacy. Future stem cell studies combined with electrical current are required to demonstrate and to confirm that electrical current enhances in vivo cellular differentiation