Influence of LINE-Assisted Provision of Information about Human Papillomavirus and Cervical Cancer Prevention on HPV Vaccine Intention: A Randomized Controlled Trial

We conducted a prospective, randomized two-arm, parallel group, and open label trial to investigate whether the use of LINE would increase HPV vaccine intention among not completely vaccinated university students. In June 2020, we recruited students aged between 18 and 35 years from four universities in Japan. Among the 357 enrollees (female, 53%), 178 and 179 participants were randomized into the LINE and Mail groups, respectively. At baseline, within three years, vaccine intention was observed in 40% vs. 42% of participants, respectively. At the first intervention, which provided similar PDF leaflets about HPV vaccine and cervical cancer prevention, there was no significant difference in vaccine intention between the two groups. However, at the second intervention of LINE-assisted knowledge intervention for 5 days per week for 7 weeks, the LINE group had a higher proportion of vaccine intention than the no intervention group (66% vs. 44%, OR: 2.62, 95% confidence interval (CI): 1.59-4.35) in per-protocol analysis. The significance remained in the intention-to-treat analysis of multiply imputed datasets. Although LINE did not directly increase HPV vaccine intention compared to conventional posts, the LINE-assisted provision of information was effective in improving HPV vaccine intention among Japanese university and college students

Laparoscopic resection of paraganglioma arising from the organ of Zuckerkandl: A case report

Abdominal paragangliomas are rare tumors that arise near the root of the inferior mesenteric artery, termed the organ of Zuckerkandl. The laparoscopic approach is technically demanding for abdominal paragangliomas and tumor handling is difficult. A 26-year-old woman presented with abdominal pain. Pelvic CT and MRI showed a round, well defined, 53 × 51-mm mass attached to the sacrum. The preoperative diagnosis was schwannoma arising from the retroperitoneum and laparoscopic tumor resection was performed. Intraoperatively, the tumor appearance was of a round, whitish mass in the retroperitoneum, with involvement of the inferior mesenteric artery, which was ligated and dissected. We used indocyanine green fluorescence imaging to assess colonic perfusion. The histological findings were consistent with paraganglioma. We performed complete resection of a paraganglioma arising from the organ of Zuckerkandl combined with resection of the inferior mesenteric artery. Indocyanine green fluorescence imaging helped confirm adequate blood flow and avoided resection of the colon.Acta medica Nagasakiensia, 67(1), pp.37-40; 202

HPV vaccine intention among university students during suspension of active recommendation in Japan

In Japan, active recommendation of the human papillomavirus vaccine was withheld between 2013 and 2021 due to adverse reaction reports. This resulted in low vaccine coverage with reports from less than 1%. This study aimed to investigate if knowledge and health-belief related factors associated with vaccine intention among young adolescents with the hope that our findings may be helpful in promotion campaigns. We recruited students in four colleges and universities in Akita Prefecture from 2020 to 2021 who had never been vaccinated. A total of 318 students (male 54%, mean age 21 years) responded to a self-administered questionnaire; only 6% reported immediate vaccine intention, and 61% reported no such intention or “do not know.” The correct percentages of 20-item knowledge about HPV vaccine-related morbidity, mortality, and prevention were very low regardless of gender (average males 41.4% vs. females 39.6%). Multivariable logistic regression models demonstrated that in males, higher levels of literacy, perceived susceptibility, and place for vaccination (logistical barrier) were associated with HPV vaccine intention, whereas “no need now” was associated with less intention. In females, a higher level of knowledge was significantly associated with vaccine intention, whereas “concerns of adverse effects” were associated with less intention