In vitro flow analysis of artificial heart valve

Abstract not available

Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models

In native articular cartilage, chondrocytes are surrounded by a thin pericellular matrix (PCM) forming chondrons. The PCM is exclusively rich in type VI collagen. The retention of the PCM has a significant influence on the metabolic activity of the chondrocytes

Further discussion on in vitro flow analysis of artificial heart valve

Abstract not available

Intimal hyperplasia and wall shear in arterial bypass Y-grafting and consequence grafting: a numerical study

The progression of intimal hyperplasia is considered to be the main cause of bypass failure and is directly related to the individual blood rheology, local arterial geometry and placement of the junctions, graft diameter and graft surface characteristics as well as the degree of compliance. In this paper we use commercial computational fluid dynamics (CFD) ANSYS to examine under the correct physiological flow conditions the hemodynamic forces of composite bypass with internal mammary artery in Y-grafting and consequence grafting which is known to achieve high patency rate and highly recommended by clinicians. Particular emphasis is given here on the parameters that could initiate the development of intimal hyperplasia within these bypass configurations. The hemodynamic flow patterns between the consequence grafting and the composite Y-grafting are observed here to be different. Moreover, on both end-to-side and side-to-side configurations, the circulating flows are detected in the vicinity of the junction area, while the Dean flow vortexes are only observed on the end-to-side configuration. Likewise, the hemodynamic flow on the end-to-side configuration on the LCX of both 45 degrees and 90 degrees Y-grafting is found to be smoother than that of the junction on the LCA, regardless of the changing of anastomosis angles. The high WSS gradients are observed at the vicinity of the toe and on the bed of the junction, while the low WSS are presented at the distal of the stenosis and at the stagnation point. The clinical relevance of the results are presented and discussed with particular focus on the factors and the flow patterns that trigger the development of intimal hyperplasia

In vitro haemodynamic and computer aided design of an artificial coronary arteries

Abstract not available

Silicone and Pyrocarbon Artificial Finger Joints

Artificial finger joint design has been developed through different stages through the past. PIP (proximal interphalangeal) and MCP (metacarpophalangeal) artificial finger joints have come to replace the amputation and arthrodesis options; although, these artificial joints are still facing challenges related to reactive tissues, reduced range of motion, and flexion and extension deficits. Swanson silicone artificial finger joints are still common due to the physician’s preferability of silicone with the dorsal approach during operation. Nevertheless, other artificial finger joints such as the pyrocarbon implant arthroplasty have also drawn the interests of practitioners. Artificial finger joint has been classified under three major categories which are constrained, unconstrained, and linked design. There are also challenges such as concerns of infections and articular cartilage necrosis associated with attempted retention of vascularity. In addition, one of the main challenges facing the silicone artificial finger joints is the fracture occurring at the distal stem with the hinge. The aim of this paper is to review the different artificial finger joints in one paper as there are few old review papers about them. Further studies need to be done to develop the design and materials of the pyrocarbon and silicone implants to increase the range of motion associated with them and the fatigue life of the silicone implants

Microwave sterilization of bovine pericardium for heart valve applications

It is widely recognised that the bioprosthetic valves widely used for heart valve replacements have some drawbacks, for example tearing and occurrence of infections, which can be attributed to the fixation and sterilization techniques currently available. These techniques adversely affect the physical properties, functionality, and lifespan of the leaflets. In the work discussed in this paper we examined a novel procedure of using high-frequency microwaves to fix and disinfect the pericardium, without causing any harmful affects. The test bacteria used were Escherichia coli and Staphylococcus aureus. The pericardium was exposed to microwaves at a frequency of 18 GHz for three consecutive replicates. The findings indicated that there was almost complete inactivation of the bacteria on the biomaterial without compromising the biocompatibility, which was studied using ovine fibroblasts. An effective fixation and sterilization procedure, that is quick and has no adverse effects is presented and discussed