10 research outputs found

    Development of quality indicators based on a multidisciplinary, evidence-based guideline on pediatric constipation

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    Several clinical guidelines for childhood functional constipation have been developed, but none of them is accompanied by a set of quality indicators. It is important to gain insight into the quality of care in daily practice in order to improve the implementation of clinical guidelines. This can be done by developing and measuring quality indicators. We identified a set of quality indicators for diagnosis and treatment of children with functional constipation, based on the existing Dutch evidence-based multidisciplinary guideline 'Functional constipation in children between 0 and 18 years' and expert opinions of professionals and patients. Assessment of the initial 84 potential quality indicators was done by using a RAND-modified Delphi method. The final set consisted of seven representative quality indicators (one structure and six process quality indicators) for children with functional constipation, covering the dimensions of diagnosis, medical treatment, non-medical treatment and referral. This study describes a systematic method to develop a set of seven process and structure quality indicators that can be used to monitor quality of health care for children with functional constipatio

    Depressive symptoms and emotional eating: Mediated by mindfulness?

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    The association between depressive symptoms and emotional eating has been well established. The aim of the current study was to examine whether the association between depressive symptoms and emotional eating was mediated by mindfulness, a construct that has successfully been implemented in the treatment of eating disorders and depression. Mindfulness, particularly, the component "acting with awareness" was theorized to decrease impulsive eating. Data from 417 Dutch adult participants were analyzed. Mediation analyses were conducted using structural equation modeling in Mplus. Of the five mindfulness subcomponents, only acting with awareness mediated the association between depressive symptoms and emotional eating. Results showed complete mediation in that the effect of depression on emotional eating was entirely carried indirectly through the mediator acting with awareness. None of the other mindfulness components mediated the depressive symptoms-emotional eating link. This indicates the potential importance of the "acting with awareness" construct, explaining why depressive symptoms would be associated with emotional eating. Future prospective research should examine whether, why and for whom acting with awareness may mediate the prospective link from depressive symptoms to emotional eating

    Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

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    Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits

    Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology

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    Background: Long-term effects of assisted reproductive technology (ART) on ovarian tumor risk are unknown. Methods: This nationwide cohort study comprises 30 625 women who received ovarian stimulation for ART in 1983-2000 and 9988 subfertile women not treated with ART. Incident invasive and borderline ovarian tumors were ascertained through linkage with the Netherlands Cancer Registry and the Dutch Pathology Registry until July 2018. Ovarian tumor risk in ART-treated women was compared with risks in the general population and the subfertile non-ART group. Statistical tests were 2-sided. Results: After a median follow-up of 24 years, 158 invasive and 100 borderline ovarian tumors were observed. Ovarian cancer risk in the ART group was increased compared with the general population (standardized incidence ratio [SIR] = 1.43, 95% confidence interval [CI] = 1.18 to 1.71) but not when compared with the non-ART group (age- and parity-adjusted hazard ratio [HR] = 1.02, 95% CI = 0.70 to 1.50). Risk decreased with higher parity and with a larger number of successful ART cycles (resulting in childbirth, Ptrend = .001) but was not associated with the number of unsuccessful ART cycles. Borderline ovarian tumor risk was increased in ART-treated women compared with the general population (SIR = 2.20, 95% CI = 1.66 to 2.86) and with non-ART women (HR = 1.84, 95% CI = 1.08 to 3.14). Risk did not increase with more ART cycles or longer follow-up time. Conclusions: Increased ovarian cancer risk in ART-treated women compared with the general population is likely explained by nulliparity rather than ART treatment. The increased risk of borderline ovarian tumors after ART must be interpreted with caution because no dose-response relationship was observed.Cervix cance
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