Relatively higher norms of blood flow velocity of major intracranial arteries in North-West Iran

<p>Abstract</p> <p>Background</p> <p>Transcranial Doppler (TCD) is a noninvasive, less expensive and harmless hemodynamic study of main intracranial arteries. The aim of this study was to assess normal population values of cerebral blood flow velocity and its variation over age and gender in a given population.</p> <p>Findings</p> <p>Eighty healthy volunteers including 40 people with an age range of 25-40 years (group1) and 40 persons with an age range of 41-55 years (group2) were studied. In each group 20 males and 20 females were enrolled. Peak systolic, end diastolic and mean velocities of nine main intracranial arteries were determined using TCD. Mean age of the studied volunteers was 31.6 ± 4.50 years in group one and 47.2 ± 4.3 years in group two. Mean age among males was 40 years and among females it was 39. Mean blood flow velocity in middle, anterior and posterior cerebral arteries, vertebral and basilar arteries was 60 ± 8, 52 ± 9, 42 ± 6, 39 ± 8 and 48 ± 8 cm/sec respectively. Cerebral blood flow velocities among females were relatively higher than males. Cerebral blood flow velocity of left side was relatively higher than right side.</p> <p>Conclusion</p> <p>Compared to previous studies, cerebral blood flow velocity in this population was relatively higher.</p

Etudes précliniques de candidats vaccins contre le paludisme (analyses immuno-épidémiologiques et validation d'un test fonctionnel de chimiluminescence)

Un vaccin contre Plasmodium falciparum est une grande priorité. Il est difficile de tester les candidats vaccins en essai clinique, et sans un bon modèle animal, des tests fonctionnels d anticorps in vitro sont nécessaires pour choisir les meilleurs candidats. Ce travail décrit un test mesurant l activation des neutrophiles (poussée respiratoire) et la phagocytose des mérozoïtes en présence d anticorps anti-mérozoïte, par chimiluminescence. Ce test est reproductible et relié à la protection clinique en zone d endémie. Les anticorps spécifiques de PfMSP1p19 et PfMSP4p20 exprimé en baculovirus sont fonctionnels dans ce test. Avec une reproductibilité confirmée ailleurs, il pourrait devenir un outil de référence. Une autre approche immuno-épidémiologique démontre une corrélation entre le taux d anticorps anti-PfMSP1p19 ou anti-PfMSP5 et la protection clinique.PARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF