Summaries

Приведены рефераты статей данного номера на английском языке

Инженерно-геологические условия и проект изысканий под строительство 10-ти этажного здания в микрорайоне Восточный (г. Томск)

Данная работа представляет собой проект изысканий на участке строительства жилого 10-ти этажного здания в микрорайоне Восточный города Томска. Цель дипломного проекта – дать характеристику инженерно-геологических условий площадки строительства жилого 10-ти этажного здания в микрорайоне Восточный города Томска и составить проект изысканий под данное здание.This work is a refined project on the site of construction of a residential 10-storey building in the Vostochny micro-district of the city of Tomsk. The purpose of the diploma project is to give a description of the engineering and geological conditions of the construction site for a 10-storey building in the residential area of the Eastern city of Tomsk and to design a refined project for the annotation of the building

The sequences of 150,119 genomes in the UK Biobank

Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic diversity depends on a comprehensive and reliable characterization of both sequences and phenotypic variation. Over the past decade, insights into this relationship have been obtained from whole-exome sequencing or whole-genome sequencing of large cohorts with rich phenotypic data(1,2). Here we describe the analysis of whole-genome sequencing of 150,119 individuals from the UK Biobank(3). This constitutes a set of high-quality variants, including 585,040,410 single-nucleotide polymorphisms, representing 7.0% of all possible human single-nucleotide polymorphisms, and 58,707,036 indels. This large set of variants allows us to characterize selection based on sequence variation within a population through a depletion rank score of windows along the genome. Depletion rank analysis shows that coding exons represent a small fraction of regions in the genome subject to strong sequence conservation. We define three cohorts within the UK Biobank: a large British Irish cohort, a smaller African cohort and a South Asian cohort. A haplotype reference panel is provided that allows reliable imputation of most variants carried by three or more sequenced individuals. We identified 895,055 structural variants and 2,536,688 microsatellites, groups of variants typically excluded from large-scale whole-genome sequencing studies. Using this formidable new resource, we provide several examples of trait associations for rare variants with large effects not found previously through studies based on whole-exome sequencing and/or imputation

Systems of Differential Algebraic Equations in Computational Electromagnetics

Starting from space-discretisation of Maxwell's equations, various classical formulations are proposed for the simulation of electromagnetic fields. They differ in the phenomena considered as well as in the variables chosen for discretisation. This contribution presents a literature survey of the most common approximations and formulations with a focus on their structural properties. The differential-algebraic character is discussed and quantified by the differential index concept