Association Between Obesity and C-reactive Protein in Type 2 Diabetic Patients

Aim: Obesity is a major health problem causing major illnesses and diseases. In this study, we aimed to differentiate type 2 diabetic normal, overweight and obese people to investigate the relationship of obesity with C-reactive protein (Hs-CRP), an inflammatory identifier. Methods: The study was conducted on a total of 129 patients (64 female, 65 male) with type 2 diabetes mellitus between May 2010 and September 2010. Study consisted of three groups, classified according to body mass; 16 normal weight, 55 overweight and 58 obese patient. Hs-CRP levels were measured by immunoassay chemiluminescence. All data were statistically analyzed. Results: A significant difference in hs-CRP levels was determined between the groups (p<0.05). Hs-CRP levels in subjects with normal body weight were found to be significantly lower than in obese ones (p<0.05). There was no significant difference in age, cholesterol parameters and HbA1c between the groups. No significant difference was observed in BMI between genders (p<0.05). Based on BMI, the rate of obese women was considerably higher than the rate of overweight and normal women (p<0.05). Similarly, the rate of overweight and normal men was significantly higher than the rate of obese men (p<0.05). Conclusion: Hs-CRP levels in people with normal body weight were confirmed to be significantly lower than those in obese people (p<0.05). Hs-CRP levels were observed to be increased with weight gain. (The Medical Bulletin of Haseki 2013; 51: 120-4

The Evaluation of Liver Steatosis with Transient Elastography in Metabolic Syndrome and the Relationship Between Serum Endorphin Levels

Objective: Studies in recent times researching the correlation between serum endotrophinlevel and Type 2 DM have focused on the association of fatty liver with metabolic syndrome.This study aims to research the correlation between serum endotrophin levels, defined asa marker of metabolic dysregulation, with nonalcoholic fatty liver in metabolic syndromepatients, with increasing prevalence.Methods: Our prospective study included 40 patients (24 females and 16 males) with metabolicsyndrome attending the internal medicine clinic and 20 healthy volunteers (ten femalesand ten males). Evaluation of patients in terms of liver steatosis used transabdominal ultrasonographywith a Toshiba 500 Aplio brand model ultrasound device with 10 MHz convexprobe with transient elastography method. Fatty Liver Index and Hepatic Steatosis Index(HSI) were calculated on the basis sample analyses. The endotrophin levels were studiedwith a Sunred enzyme-linked ımmunosorbent assay kit.Results: Endotrophin levels were found to be lower in the group with metabolic syndromecompared to the healthy group and results were statistically significant different (p<0.001).When the mean elastography results for the groups (in m/s and kPa) are compared, therewere statistically significant differences found (p=0.001, p<0.001). There were statisticallysignificant differences between HSI score with serum insulin levels and homeostasis modelassessment results.Conclusion: In our study, a correlation was not found between endotrophin levels and fattyliver. Endotrophin is a parameter with newly discovered effects and is being researched forapplicability and reliability in clinical practice