New Supporting Evidence for the Overdensity of Galaxies around the Radio-Loud Quasar SDSS J0836+0054 at z =5.8

Recently, Zheng et al. (2005) found evidence for an overdensity of galaxies around a radio-loud quasar, SDSS J0836+0054, at z=5.8 (a five arcmin$^2$ region). We have examined our deep optical imaging data (B, V, r', i', z', and NB816) taken with the Suprime-Cam on the Subaru Telescope. The NB816 narrow-band filter (lambda_c = 815 nm and $\Delta\lambda = 12$ nm) is suitable for searching for Ly$\alpha$ emitters at $z\approx 5.7$. We have found a new strong Ly$\alpha$ emitter at $z \approx 5.7$ close to object B identified by Zheng et al. Further, the non detection of the nine objects selected by Zheng et al. (2005) in our B, V, and r' images provides supporting evidence that they are high-z objects.Comment: 5 pages, 1 figure, accepted for PAS

Strong Emission-Line Galaxies at Low Redshift in the Field around the Quasar SDSSp J104433.04-012502.2

We discuss observational properties of strong emission-line galaxies at low redshift found by our deep imaging survey for high-redshift Ly alpha emitters. In our surveys, we used the narrowband filter, NB816 (lambda_center=8150A with FWHM = 120A), and the intermediate-band filter, IA827 (lambda_center = 8270A with FWHM = 340A). In this survey, 62 NB816-excess (> 0.9 mag) and 21 IA827-excess (> 0.8 mag) objects were found. Among them, we found 20 NB816-excess and 4 IA827-excess Ly alpha emitter candidates. Therefore, it turns out that 42 NB816-excess and 17 IA827-excess objects are strong emission-line objects at lower redshift. Since 4 objects in the two low-z samples are common, the total number of strong low-z emitters is 55. Applying our photometric redshift technique, we identify 7 H alpha emitters at z~0.24, 20 H beta-[OIII] ones at z~0.65, and 11 [OII] ones at z~1.19. However, we cannot determine reliable photometric redshifts of the remaining 17 emitters. The distributions of their rest frame equivalent widths are consistently understood with recent studies of galaxy evolution from z~1 to z~0.Comment: 28 pages, 8 figures, PASJ, Vol. 58, No. 1, in pres

A survey of NB921 dropouts in the Subaru Deep Field

In order to search for high-redshift galaxies beyond $z = 6.6$ in the Subaru Deep Field, we have investigated NB921-dropout galaxies where NB921 is the narrowband filter centered at 919.6 nm with FWHM of 13.2 nm for the Suprime-Cam on the Subaru Telescope. There are no secure NB921-dropout candidates brighter than $z^\prime = 25.5$. Based on this result, we discuss the UV luminosity function of star-forming galaxies at $z > 6.6$.Comment: 10 pages, 5 figures, PASJ, Vol.57, No.5, in pres

Identification of a novel biomarker candidate, a 4.8-kDa peptide fragment from a neurosecretory protein VGF precursor, by proteomic analysis of cerebrospinal fluid from children with acute encephalopathy using SELDI-TOF-MS

<p>Abstract</p> <p>Background</p> <p>Acute encephalopathy includes rapid deterioration and has a poor prognosis. Early intervention is essential to prevent progression of the disease and subsequent neurologic complications. However, in the acute period, true encephalopathy cannot easily be differentiated from febrile seizures, especially febrile seizures of the complex type. Thus, an early diagnostic marker has been sought in order to enable early intervention. The purpose of this study was to identify a novel marker candidate protein differentially expressed in the cerebrospinal fluid (CSF) of children with encephalopathy using proteomic analysis.</p> <p>Methods</p> <p>For detection of biomarkers, CSF samples were obtained from 13 children with acute encephalopathy and 42 children with febrile seizure. Mass spectral data were generated by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) technology, which is currently applied in many fields of biological and medical sciences. Diagnosis was made by at least two pediatric neurologists based on the clinical findings and routine examinations. All specimens were collected for diagnostic tests and the remaining portion of the specimens were used for the SELDI-TOF MS investigations.</p> <p>Results</p> <p>In experiment 1, CSF from patients with febrile seizures (n = 28), patients with encephalopathy (n = 8) (including influenza encephalopathy (n = 3), encephalopathy due to rotavirus (n = 1), human herpes virus 6 (n = 1)) were used for the SELDI analysis. In experiment 2, SELDI analysis was performed on CSF from a second set of febrile seizure patients (n = 14) and encephalopathy patients (n = 5). We found that the peak with an m/z of 4810 contributed the most to the separation of the two groups. After purification and identification of the 4.8-kDa protein, a 4.8-kDa proteolytic peptide fragment from the neurosecretory protein VGF precursor (VGF4.8) was identified as a novel biomarker for encephalopathy.</p> <p>Conclusions</p> <p>Expression of VGF4.8 has been reported to be decreased in pathologically degenerative changes such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, and encephalopathy. Thus, the VGF4.8 peptide might be a novel marker for degenerative brain conditions.</p

Prophylactic clip closure for mucosal defects is associated with reduced adverse events after colorectal endoscopic submucosal dissection: a propensity-score matching analysis

博士（医学）乙日本医科大学202

Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer

<p>Abstract</p> <p>Background</p> <p>The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer.</p> <p>Methods</p> <p>Six patients with advanced pancreatic cancer were enrolled in this pharmacokinetics (PK) study. These patients were treated by oral administration of S-1 30 mg/m²twice daily for 28 consecutive days, followed by a 14-day rest period and intravenous administration of GEM 800 mg/m²on days 1, 15 and 29 of each course. The PK parameters of GEM and/or 5-FU after GEM single-administration, S-1 single-administration, and co-administration of GEM with pre-administration of S-1 at 2-h intervals were analyzed.</p> <p>Results</p> <p>The maximum concentration (Cmax), the area under the curve from the drug administration to the infinite time (AUCinf), and the elimination half-life (T1/2) of GEM were not significantly different between GEM administration with and without S-1. The Cmax, AUCinf, T1/2, and the time required to reach Cmax (Tmax) were not significantly different between S-1 administration with and without GEM.</p> <p>Conclusion</p> <p>There were no interactions between GEM and S-1 regarding plasma PK of GEM and 5-FU.</p

Efficacy and Safety of an Ultrasonically Activated Device for Sealing the Bile Ducts During Liver Resection

The use of ultrasonically activated devices (USADs) in hepatic resections may be associated with an increased rate of complications, such as postoperative bile leaks. Nonetheless, the safety of USADs for sealing bile ducts during liver surgery has not yet been established. The purpose of this study was to assess the efficacy of a USAD for sealing bile ducts. In animal experiments, the common bile duct of ten anesthetized dogs was individually occluded using a USAD. Additionally, using the prospective liver surgery database from a single institution, we identified 45 consecutive patients who underwent hepatic resection using a USAD (USAD group) and 45 similar patients who underwent hepatic resection without the use of a USAD (NUSAD group). In the occluded and harvested canine bile ducts, the mean burst pressure was 280mmHg, and the lumen of the bile duct was completely sealed morphologically. In the clinical study, there was no significant difference in postoperative mortality or complications between the two groups, and biliary leakage was observed in only one patient (0.7%) in the USAD group. These data demonstrate that the USAD is a safe, efficient, and practical instrument for use during liver surgery to achieve complete hemobiliary stasis

The Japanese space gravitational wave antenna; DECIGO

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing various mysteries of the universe such as dark energy, formation mechanism of supermassive black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of three drag-free spacecraft, whose relative displacements are measured by a differential Fabry– Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre- DECIGO first and finally DECIGO in 2024

DECIGO pathfinder

DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected to provide us fruitful insights into the universe, in particular about dark energy, a formation mechanism of supermassive black holes, and the inflation of the universe. Since DECIGO will be an extremely large mission which will formed by three drag-free spacecraft with 1000m separation, it is significant to gain the technical feasibility of DECIGO before its planned launch in 2024. Thus, we are planning to launch two milestone missions: DPF and pre-DECIGO. The conceptual design and current status of the first milestone mission, DPF, are reviewed in this article