Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth

External pical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in post-orthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL-1ra protein have a positive/negative influence on EARR of endodontically-treated teeth. Ninety-three orthodontic patients were genetically screened for a single nucleotide polymorphism (SNP: rs419598) in the IL1 cluster. The sample was classified into 2 groups: group 1 (affected-group) showed radiographic EARR of more than 2mm; group 2 (control-group), had no EARR or EARR <= to 2mm following orthodontic treatment on root-filled teeth. Logistic regression analysis was performed to obtain an adjusted estimate between the SNPs studied and EARR. Genotype distributions, allelic frequencies, adjusted odds ratios (OR) and 95% confidence intervals were also calculated. We found that subjects homozygous [1/1(TT)] for the IL1RN gene [OR: 10.85; p=0.001; CI: 95%] were at risk of EARR in root-filled teeth. Genetic variants in the antagonist axis balance of the IL1RN(rs419598) have a direct repercussion on the predisposition to post-orthodontic EARR in root-filled teeth. Variants in allele 1 of the interleukin-1 receptor antagonist gene(rs419598) are associated(p=0.001**) with an increased risk of suffering post-orthodontic EARR in root-filled teeth

Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth

y. External pical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in postorthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL1ra protein have a positive/negative influence on EARR of endodontically-treated teeth. Ninety-three orthodontic patients were genetically screened for a single nucleotide polymorphism (SNP:rs419598) in the IL1 cluster. The sample was classified into 2 groups: group 1 (affectedgroup) showed radiographic EARR of more than 2mm; group 2 (control-group), had no EARR or EARR≤ to 2mm following orthodontic treatment on root-filled teeth. Logistic regression analysis was performed to obtain an adjusted estimate between the SNPs studied and EARR. Genotype distributions, allelic frequencies, adjusted odds ratios (OR) and 95% confidence intervals were also calculated. We found that subjects homozygous [1/1(TT)] for the IL1RN gene [OR:10.85; p=0.001;CI:95%] were at risk of EARR in root-filled teeth. Genetic variants in the antagonist axis balance of the IL1RN(rs419598) have a direct repercussion on the predisposition to post-orthodontic EARR in root-filled teeth. Variants in allele 1 of the interleukin-1 receptor antagonist gene(rs419598) are associated(p=0.001**) with an increased risk of suffering post-orthodontic EARR in root-filled teeth

Triadas civicas relacionales en la comuna dos del municipio de Soacha desde las dinámicas relacionales. Realidades territoriales de Soacha 2016.

Comprender las dinámicas relacionales de los habitantes de la comuna dos de Soacha Cundinamarca con el fin de describir la vida cotidiana, la funcionalidad o disfuncionalidad de los roles adoptados en los ámbitos sociales, familiares, políticos públicos, y demás escenarios en los que se podrían desarrollar como individuos. Sumando a este el observar e interpretar los mecanismos que regulan la interacción, la adaptación y la resolución de conflictos dentro de la comunidad, además de los patrones que caracterizan este proceso y en los que se reflejen las situaciones propias de su realidad socia

Triadas civicas relacionales en la comuna dos del municipio de Soacha desde las dinámicas relacionales. Realidades territoriales de Soacha 2016.

Comprender las dinámicas relacionales de los habitantes de la comuna dos de Soacha Cundinamarca con el fin de describir la vida cotidiana, la funcionalidad o disfuncionalidad de los roles adoptados en los ámbitos sociales, familiares, políticos públicos, y demás escenarios en los que se podrían desarrollar como individuos. Sumando a este el observar e interpretar los mecanismos que regulan la interacción, la adaptación y la resolución de conflictos dentro de la comunidad, además de los patrones que caracterizan este proceso y en los que se reflejen las situaciones propias de su realidad socia