Peranan Kepemimpinan Camat Dalam Menumbuhkan Kedisiplinan Pegawai Di Kantor Kecamatan Jebres Kota Surakarta

Absract: The objectives of this research are to investigate: (1) how Chief of Jebres Sub-district Office, Surakarta city plays his leadership role in growing the discipline behavior of its employees; (2) what constraints are encountered by Chief of Jebres Sub-district Office, Surakarta city in internalizing the discipline of its employees; and (3) what solutions are taken by Chief of Jebres Sub-district Office to deal with the prevailing constraints to the materialization of the discipline behavior of its employees. This research used the qualitative embedded single case study method. The results of the research are as follows: 1) Chief of Jebres Sub-district Office, Surakarta city plays his leadership role through the discipline behavior internalizations such as: (a) giving exemplification through discipline attitude; (b) giving motivation to the employees; (c) attempting to fulfill their needs and prosperity; and (d) implementing the discipline upholding consistently. 2) The constraints occurring in nurturing the discipline of the employees of Jebres Sub-district Office are as follows: (a) internal constraints: some employees bear the characters and personalities which are apathetic to advices, and some are lack of responsibilities in executing their duties and work and (b) external constraints: the external constraints occurring in internalizing the discipline of the employees of Jebres Sub-district Office are mainly related to the work environment. 3) The prevailing constraints occurring in internalizing the discipline of the employees are as follows: (a) upholding the prevailing laws and regulations and nurturing the employees; and (b) maintaining the communication and good relations among the employees

Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort

STUDY FUNDING The data were collected by a Research into Ageing programme grant; research continues as part of the Age UK–funded Disconnected Mind project. The work was undertaken by The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross-council Lifelong Health and Wellbeing Initiative (MR/K026992/1), with funding from the BBSRC and Medical Research Council. Imaging and image analysis was performed at the Brain Research Imaging Centre (sbirc.ed.ac.uk/), Edinburgh, supported by the Scottish Funding Council SINAPSE Collaboration. Derivation of mean cortical thickness measures was funded by the Scottish Funding Council’s Postdoctoral and Early Career Researchers Exchange Fund awarded by SINAPSE to David Alexander Dickie. L.C.A.C. acknowledges funding from the Scottish Government's Rural and Environment Science and Analytical Services (RESAS) division.Peer reviewedPublisher PD

Proyecto de educación ambiental basado en el uso de medios de transporte ecológico en los barrios el Paraíso Mirador, Ilimani y las Manitas en Bogotá

Con nuestro Proyecto Aplicado concebimos la idea de capacitar a una población vulnerable a nivel social de estrato 1 y 2, como lo son los barrios Paraíso Mirador, Ilimaní y las Manitas de Bogotá, ubicado en la localidad UPZ67 de Ciudad Bolívar, al sur de la capital. Su problemática radica en la dificultad para transportarse a sus lugares de trabajo y demás actividades de forma segura y rápida y así lograr calidad de vida. Para esto, implementamos una investigación con una metodología mixta, cualitativa y cuantitativa cuyos resultados, basados en todos los procesos del PMBOK, fueron aprobados en un 100% por Juicio de Expertos. Estos resultados corroboran que la solución radica en un plan de Educación Ambiental con el fin de sensibilizar la población para que tomen ventaja de medios de transporte alternativos ecológicos. La temática de dicha capacitación está enfocada en Biodiversidad, Contaminación, Desarrollo Sostenible y Consumo Responsable.With our Applied Project we have conceived the idea of capacitating a socially vulnerable population of an economical/social level of 1 and 2 in a normal scale of 1 to 5, such as Paraiso Mirador, Ilimani and Las Manitas neighborhoods in Bogota at the localidad UPZ67 of Ciudad Bolivar in the south of the capital. Its problematic hinges upon the difficulty of quick and secure transportation to work places and other activities, and thus preventing a good quality of life. In order to achieve this, we have carried out an investigaiton with a mixed, qualitative and quantative methodology. Its results, while based on all the processes of the PMBOK, were approved in its totatility by judgment of experts. Such results corroborate that the solution is a plan of Environmental Education which will sensitivize the population who will take advantage of alternative/eco-friendly transportation. The thematic of such capacitaiton is focused on Biodiversity, Contamination, Sustainable Development and Responsible Consumption

Epigenetic Mechanisms Regulate MHC and Antigen Processing Molecules in Human Embryonic and Induced Pluripotent Stem Cells

Background Human embryonic stem cells (hESCs) are an attractive resource for new therapeutic approaches that involve tissue regeneration. hESCs have exhibited low immunogenicity due to low levels of Mayor Histocompatibility Complex (MHC) class-I and absence of MHC class-II expression. Nevertheless, the mechanisms regulating MHC expression in hESCs had not been explored. Methodology/Principal Findings We analyzed the expression levels of classical and non-classical MHC class-I, MHC class-II molecules, antigen-processing machinery (APM) components and NKG2D ligands (NKG2D-L) in hESCs, induced pluripotent stem cells (iPSCs) and NTera2 (NT2) teratocarcinoma cell line. Epigenetic mechanisms involved in the regulation of these genes were investigated by bisulfite sequencing and chromatin immunoprecipitation (ChIP) assays. We showed that low levels of MHC class-I molecules were associated with absent or reduced expression of the transporter associated with antigen processing 1 (TAP-1) and tapasin (TPN) components in hESCs and iPSCs, which are involved in the transport and load of peptides. Furthermore, lack of β2-microglobulin (β2m) light chain in these cells limited the expression of MHC class I trimeric molecule on the cell surface. NKG2D ligands (MICA, MICB) were observed in all pluripotent stem cells lines. Epigenetic analysis showed that H3K9me3 repressed the TPN gene in undifferentiated cells whilst HLA-B and β2m acquired the H3K4me3 modification during the differentiation to embryoid bodies (EBs). Absence of HLA-DR and HLA-G expression was regulated by DNA methylation. Conclusions/Significance Our data provide fundamental evidence for the epigenetic control of MHC in hESCs and iPSCs. Reduced MHC class I and class II expression in hESCs and iPSCs can limit their recognition by the immune response against these cells. The knowledge of these mechanisms will further allow the development of strategies to induce tolerance and improve stem cell allograft acceptance

Clinical trial recruitment of people who speak languages other than English: a Childrens Oncology Group report.

BACKGROUND: Persons who speak languages other than English are underrepresented in clinical trials, likely in part because of inadequate multilevel resources. We conducted a survey of institutions affiliated with the Childrens Oncology Group (COG) to characterize current research recruitment practices and resources regarding translation and interpretation services. METHODS: In October 2022, a 20-item survey was distributed electronically to institutions affiliated with COG to assess consent practices and resources for recruiting participants who speak languages other than English to COG trials. Descriptive statistics were used to summarize responses; responses were compared by institution size and type as well as respondent role. RESULTS: The survey was sent to 230 institutions, and the response rate was 60% (n = 139). In total, 60% (n = 83) of those respondents had access to short-form consent forms. Full consent form translation was required at 50% of institutions, and 12% of institutional review boards restricted use of centrally translated consent forms. Forty-six percent (n = 64) of institutions reported insufficient funding to support translation costs; 19% (n = 26) had access to no-cost translation services. Forty-four percent (n = 61) were required to use in-person interpreters for consent discussions; the most frequently cited barrier (56%) to obtaining consent was lack of available in-person interpreters. Forty-seven percent (n = 65) reported that recruiting persons who speak languages other than English to clinical trials was somewhat or very difficult. CONCLUSIONS: Institutions affiliated with COG face resource-specific challenges that impede recruitment of participants who speak languages other than English for clinical trials. These findings indicate an urgent need to identify strategies aimed at reducing recruitment barriers to ensure equitable access to clinical trials

Distribution, threats and protection of selected karst groundwater-dependent ecosystems in the Mediterranean region

Karst groundwater-dependent ecosystems (KGDEs) in the Mediterranean region are important in terms of ecosystem services and biodiversity but are increasingly under anthropogenic pressures and climate-change constraints. For this study, the ecohydrological characteristics, threats, and protection status of 112 selected KGDEs around the Mediterranean Sea, including caves, springs, rivers and wetlands, were evaluated, based on local expert knowledge and scientific literature. Results demonstrate that KGDEs contribute considerably to regional biodiversity. The diversity of karst landscapes, combined with the groundwater emergence at springs, leads to exceptional habitat diversity, particularly in arid climates, where KGDEs serve as a refuge for species that could not thrive in the surrounding environment. The most common threats identified among the selected sites are direct human disturbances, such as mass tourism or overfishing, water-quality deterioration and water shortage from aquifer overdraft and/or climate change. Although most of the selected sites are under protection, conservation measures are frequently insufficient. Such shortcomings are often caused by poor data availability, little knowledge on conservation needs of invertebrate species, and conflicts of interest with the local population. For this purpose, it is necessary to raise environmental awareness and promote interdisciplinary research, in order to monitor water quality and quantity in addition to the status of the biocenoses

Role of Physical Activity and Fitness in the Characterization and Prognosis of the Metabolically Healthy Obesity Phenotype: a Systematic Review and Meta-Analysis

The aims of the present article are to systematically review and meta-analyze the existing evidence on: 1) differences in physical activity (PA), sedentary behavior (SB), cardiorespiratory fitness (CRF) and muscular strength (MST) between metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO); and 2) the prognosis of all-cause mortality and cardiovascular disease (CVD) mortality/morbidity in MHO individuals, compared with the best scenario possible, i.e., metabolically healthy normal-weight (MHNW), after adjusting for PA, SB, CRF or MST. Our systematic review identified 67 cross-sectional studies to address aim 1, and 11 longitudinal studies to address aim 2. The major findings and conclusions from the current meta-analysis are: 1) MHO individuals are more active, spend less time in SB, and have a higher level of CRF (yet no differences in MST) than MUO individuals, suggesting that their healthier metabolic profile could be at least partially due to these healthier lifestyle factors and attributes. 2) The meta-analysis of cohort studies which accounted for PA (N = 10 unique cohorts, 100% scored as high-quality) support the notion that MHO individuals have a 24-33% higher risk of all-cause mortality and CVD mortality/morbidity compared to MHNW individuals. This risk was borderline significant/non-significant, independent of the length of the follow-up and lower than that reported in previous meta-analyses in this topic including all type of studies, which could be indicating a modest reduction in the risk estimates as a consequence of accounting for PA. 3) Only one study has examined the role of CRF in the prognosis of MHO individuals. This study suggests that the differences in the risk of all-cause mortality and CVD mortality/morbidity between MHO and MHNW are largely explained by differences in CRF between these two phenotypes

Impact evaluation methods in public economics : a brief introduction to randomized evaluations and comparison with other methods

Recent years have seen a large expansion in the use of rigorous impact evaluation techniques. Increasingly, public administrations are collaborating with academic economists and other quantitative social scientists to apply such rigorous methods to the study of public finance. These developments allow for more reliable measurements of the effects of different policy options on the behavioral responses of citizens, firm owners, or public officials. They can help decision makers in tax administrations, public procurement offices, and other public agencies design programs informed by well-founded evidence. This article provides an introductory overview of the most frequently used impact evaluation methods. It is aimed at facilitating communication and collaboration between practitioners and academics by introducing key vocabulary and concepts used in rigorous impact evaluation methods, starting with randomized controlled trials and comparing them with other methods ranging from simple pre–post analysis to difference-in-differences, matching estimations, and regression discontinuity designs

Effect of a controlled diaphragmatic breathing session on perceived pain and state anxiety in people with chronic pain

Chronic pain conditions are frequently comorbid with anxiety problems. The controlled diaphragmatic breathing technique has been applied in both conditions. However, few studies have examined its efficacy in reducing perceived pain and state anxiety in the population with both pathologies. Thus, the study objective was to investigate the immediate effects of a single-session diaphragmatic breathing intervention on perceived pain and state anxiety in a group of people with chronic pain. We analyzed the influence of sociodemographic variables, dispositional anxiety, average pain during the last week, respiratory rate, and inhalation/exhalation ratio. The sample comprised 169 people with chronic pain from Spain and Poland who were evaluated before and after performing an online controlled diaphragmatic breathing task. The Wilcoxon test showed significant decreases in state anxiety and perceived pain. Linear regression analyses revealed an association between dispositional anxiety and pretest/posttest differences in state anxiety, as well as an association between both aver- age pain in the last week and nationality and pretest/posttest differences in perceived pain. We conducted an exploratory analysis of the differences between both countries in the study variables. We discuss the results and the relevance of further studies on the efficacy of this technique in reducing perceived pain and state anxiety.Funding for open access charge : Universidad de Málaga/CBU