7 research outputs found
Need for Susceptibility Testing Guidelines for Fastidious or Less-Frequently Isolated Bacteria
textabstractFood is the major source for polychlorinated biphenyl (PCB) and dioxin
accumulation in the human body. Therefore, investigating food habits from
early ages until reproductive age (25 years) is important in order to
assess exposure risk for the next generation. The objective of this study
was to assess the PCB/dioxin exposure and the relative contribution of
different foods to total exposure during preschool age. Particularly, the
importance of lactational PCB/dioxin exposure vs. dietary exposure until
adulthood was investigated. A cohort of 207 children was studied from
birth until preschool age. Based on 3 planar PCBs and 17
2,3,7,8-substituted dibenzo-para-dioxins (PCDDs) and dibenzofurans (PCDFs)
measured in breast milk, a model was developed to calculate the cumulative
toxic equivalent (TEQ) intake during breast-feeding (0-1 year). In 3.
5-year-old children, daily dietary intake of planar PCB-TEQ and dioxin-TEQ
was measured with a validated food questionnaire. Cumulative TEQ intake
from 1 to 5 years was estimated using the PCB- and dioxin-TEQ intake
measured with the food questionnaire. Cumulative TEQ intake from 6 to 25
years was estimated using national food consumption and contamination data
of PCB- and dioxin-TEQ intake. In toddlers, dairy products contributed 43%
to PCB-TEQ and 50% to dioxin-TEQ intake. Meat and meat products
contributed 14% and 19%, respectively, and processed foods 23% and 15%,
respectively. Breast-feeding for 6 months contributed to the cumulative
PCB/dioxin TEQ intake until 25 years of age, 12% in boys and 14% in girls.
The daily TEQ intake per kilogram body weight is 50 times higher in
breast-fed infants and three times higher in toddlers than in adults.
Long-term dietary exposure to PCBs and dioxins in men and women is partly
due to breast-feeding (12 and 14%, respectively). After weaning, dairy
products, processed foods, and meat are major contributors of PCB and
dioxin accumulation until reproductive age. Instead of discouraging
breast-feeding, maternal transfer of PCBs and dioxins to the next
generation must be avoided by enforcement of strict regulations for PCB
and dioxin discharge and by reducing consumption of animal products and
processed foods in all ages