Bypass to Turbulence in Hydrodynamic Accretion Disks: An Eigenvalue Approach

Cold accretion disks such as those in star-forming systems, quiescent cataclysmic variables, and some active galactic nuclei, are expected to have neutral gas which does not couple well to magnetic fields. The turbulent viscosity in such disks must be hydrodynamic in origin, not magnetohydrodynamic. We investigate the growth of hydrodynamic perturbations in a linear shear flow sandwiched between two parallel walls. The unperturbed flow is similar to plane Couette flow but with a Coriolis force included. Although there are no exponentially growing eigenmodes in this system, nevertheless, because of the non-normal nature of the eigenmodes, it is possible to have a large transient growth in the energy of perturbations. For a constant angular momentum disk, we find that the perturbation with maximum growth has a wave-vector in the vertical direction. The energy grows by more than a factor of 100 for a Reynolds number R=300 and more than a factor of 1000 for R=1000. Turbulence can be easily excited in such a disk, as found in previous numerical simulations. For a Keplerian disk, on the other hand, similar vertical perturbations grow by no more than a factor of 4, explaining why the same simulations did not find turbulence in this system. However, certain other two-dimensional perturbations with no vertical structure do exhibit modest growth. For the optimum two-dimensional perturbation, the energy grows by a factor of ~100 for R~10^4.5 and by a factor of 1000 for R~10^6. It is conceivable that these two-dimensional disturbances might lead to self-sustained turbulence. The Reynolds numbers of cold astrophysical disks are much larger even than 10^6, therefore, hydrodynamic turbulence may be possible in disks.Comment: 39 pages including 9 figures; Final version to appear in The Astrophysical Journa

Program Applicants as a Comparison Group in Evaluating Training Programs: Theory and a Test

The authors begin with a thorough assessment of the many nonexperimental employment and training program evaluation techniques based on non-random comparison groups. These techniques typically use econometric methods to estimate the effects of employment and training programs by using comparison groups from non-program external sources. Then, recognizing the inherent drawbacks in these methods, Bell, Orr, Blomquist and Cain respond by reintroducing an evaluation method first implemented in the 1960s, the use of internal comparison groups consisting of nonparticipating program applicants. These groups include withdrawals, screen-outs and no-shows of the programs being evaluated in order to solve the selection bias problem. By applying to the program, say the authors, nonparticipating applicants reveal themselves to have some of the same difficult-to-measure, personal characteristics that inspire participants to seek help in response to their current economic situation. The methodology of this technique is updated, then tested against the random experimental findings derived from a controlled job training experiment, the AFDC Homemaker-Home Health Aide Demonstrations. Encouraging results are presented along with useful suggestions for designers and implementers of all types of program evaluations.https://research.upjohn.org/up_press/1080/thumbnail.jp

Methods Used to Evaluate Employment and Training Programs in the Past

The authors begin with a thorough assessment of the many nonexperimental employment and training program evaluation techniques based on non-random comparison groups. These techniques typically use econometric methods to estimate the effects of employment and training programs by using comparison groups from non-program external sources. Then, recognizing the inherent drawbacks in these methods, Bell, Orr, Blomquist and Cain respond by reintroducing an evaluation method first implemented in the 1960s, the use of internal comparison groups consisting of nonparticipating program applicants. These groups include withdrawals, screen-outs and no-shows of the programs being evaluated in order to solve the selection bias problem. By applying to the program, say the authors, nonparticipating applicants reveal themselves to have some of the same difficult-to-measure, personal characteristics that inspire participants to seek help in response to their current economic situation. The methodology of this technique is updated, then tested against the random experimental findings derived from a controlled job training experiment, the AFDC Homemaker-Home Health Aide Demonstrations. Encouraging results are presented along with useful suggestions for designers and implementers of all types of program evaluations.https://research.upjohn.org/up_press/1080/thumbnail.jp

Catch Me if You Can: Adaptation from Standing Genetic Variation to a Moving Phenotypic Optimum

International audienceAdaptation lies at the heart of Darwinian evolution. Accordingly, numerous studies have tried to provide a formal framework for the description of the adaptive process. Out of these, two complementary modelling approaches have emerged: While so-called adaptive-walk models consider adaptation from the successive fixation of de novo mutations only, quantitative genetic models assume that adaptation proceeds exclusively from pre-existing standing genetic variation. The latter approach, however, has focused on short-term evolution of population means and variances rather than on the statistical properties of adaptive substitutions. Our aim is to combine these two approaches by describing the ecological and genetic factors that determine the genetic basis of adaptation from standing genetic variation in terms of the effect-size distribution of individual alleles. Specifically, we consider the evolution of a quantitative trait to a gradually changing environment. By means of analytical approximations, we derive the distribution of adaptive substitutions from standing genetic variation, that is, the distribution of the phenotypic effects of those alleles from the standing variation that become fixed during adaptation. Our results are checked against individual-based simulations. We find that, compared to adaptation from de novo mutations, (i) adaptation from standing variation proceeds by the fixation of more alleles of small effect; (ii) populations that adapt from standing genetic variation can traverse larger distances in phenotype space and, thus, have a higher potential for adaptation if the rate of environmental change is fast rather than slow

Visualization of replication initiation and elongation in Drosophila

Chorion gene amplification in the ovaries of Drosophila melanogaster is a powerful system for the study of metazoan DNA replication in vivo. Using a combination of high-resolution confocal and deconvolution microscopy and quantitative realtime PCR, we found that initiation and elongation occur during separate developmental stages, thus permitting analysis of these two phases of replication in vivo. Bromodeoxyuridine, origin recognition complex, and the elongation factors minichromosome maintenance proteins (MCM)2–7 and proliferating cell nuclear antigen were precisely localized, and the DNA copy number along the third chromosome chorion amplicon was quantified during multiple developmental stages. These studies revealed that initiation takes place during stages 10B and 11 of egg chamber development, whereas only elongation of existing replication forks occurs during egg chamber stages 12 and 13. The ability to distinguish initiation from elongation makes this an outstanding model to decipher the roles of various replication factors during metazoan DNA replication. We utilized this system to demonstrate that the pre–replication complex component, double-parked protein/cell division cycle 10–dependent transcript 1, is not only necessary for proper MCM2–7 localization, but, unexpectedly, is present during elongation

Pre-trilostane and 3-hour post-trilostane cortisol to monitor trilostane therapy in dogs

It is recommended that trilostane therapy of canine hyperadrenocorticism is monitored using an ACTH stimulation test, however this has never been validated. Three cortisol concentrations (pre-trilostane, 3-hour posttrilostane and 1-hour post-ACTH stimulation) were compared to a clinical score obtained from an owner questionnaire. There were 110 sets of 3 cortisol measurements and questionnaires obtained from 67 trilostane treated dogs. Questionnaire results were used to classify each dog as well or unwell. Well dogs were then categorised as having excellent, moderate or poor hyperadrenocorticism control, using thresholds produced by 14 independent veterinarians. Correlation co-efficients were used to compare the three cortisol concentrations to the owner score and the Kruskal Wallis and Mann-Whitney U tests were used to compare the three cortisol concentrations between categories of control. Cortisol cut-off values between significantly different categories were determined using ROC curves. Pre-trilostane and 3-hour post-trilostane cortisol were better correlated to the owner score and had cut-offs to differentiate between categories of control that had superior sensitivity and specificity results, than the post-ACTH cortisol. Iatrogenic hypoadrenocorticism was not detected in any unwell dog. This study shows that the pre-trilostane and 3-hour post-trilostane cortisol are potentially better monitoring methods than the ACTH stimulation test