Velocity correlations in dense granular flows observed with internal imaging

We show that the velocity correlations in uniform dense granular flows inside a silo are similar to the hydrodynamic response of an elastic hard-sphere liquid. The measurements are made using a fluorescent refractive index matched interstitial fluid in a regime where the flow is dominated by grains in enduring contact and fluctuations scale with the distance traveled, independent of flow rate. The velocity autocorrelation function of the grains in the bulk shows a negative correlation at short time and slow oscillatory decay to zero similar to simple liquids. Weak spatial velocity correlations are observed over several grain diameters. The mean square displacements show an inflection point indicative of caging dynamics. The observed correlations are qualitatively different at the boundaries.Comment: 11 pages, 4 figure

Solid-fluid transition in a granular shear flow

The rheology of a granular shear flow is studied in a quasi-2d rotating cylinder. Measurements are carried out near the midpoint along the length of the surface flowing layer where the flow is steady and non-accelerating. Streakline photography and image analysis are used to obtain particle velocities and positions. Different particle sizes and rotational speeds are considered. We find a sharp transition in the apparent viscosity ($\eta$) variation with rms velocity ($u$). In the fluid-like region above the depth corresponding to the transition point (higher rms velocities) there is a rapid increase in viscosity with decreasing rms velocity. Below the transition depth we find $\eta \propto u^{-1.5}$ for all the different cases studied and the material approaches an amorphous solid-like state deep in the layer. The velocity distribution is Maxwellian above the transition point and a Poisson velocity distribution is obtained deep in the layer. The observed transition appears to be analogous to a glass transition.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

SURFACE GRANULAR FLOWS: TWO RELATED EXAMPLES

Granular surface flows are common in industrial practice and natural systems, however, theoretical description of such flows is at present incomplete. Two prototype systems involving surface flow are compared: heap formation by pouring at a point and rotating cylinders. Continuum models for analysis of these flows are reviewed, and experimental results for quasi-2D systems are presented. Experimental results in both systems are well described by continuum models.Complex systems, granular flow, rotating cylinder, heap flow, continuum model

Surface flow of granular materials: model and experiments in heap formation

Granular surface flows are important in industrial practice and natural systems, but the understanding of such flows is at present incomplete. We present a combined theoretical and experimental study of quasi-two-dimensional heap formation by pouring particles continuously at a point. Two cases are considered: open systems and closed systems. Experimental results show that the shear rate in the flowing layer is nearly independent of the mass flow rate, and the angle of static friction at the bed-layer interface increases with flow rate. Predictions of the model for the flowing layer thickness and interface angles are in good agreement with experiments

In vitro and in vivo effects of adiponectin on bone

Fat mass impacts on both bone turnover and bone density and is a critical risk factor for osteoporotic fractures. Adipocyte-derived hormones may contribute to this relationship, and adiponectin is a principal circulating adipokine. However, its effects on bone remain unclear. We have, therefore, investigated the direct effects of adiponectin on primary cultures of osteoblastic and osteoclastic cells in vitro and determined its integrated effects in vivo by characterizing the bone phenotype of adiponectin-deficient mice. Adiponectin was dose-dependently mitogenic to primary rat and human osteoblasts (∼50% increase at 10 μg/ml) and markedly inhibited osteoclastogenesis at concentrations of 1 μg/ml or greater. It had no effect on osteoclastogenesis in RAW-264.7 cells or on bone resorption in isolated mature osteoclasts. In adiponectin knockout (AdKO) male C57BL/6J mice, trabecular bone volume and trabecular number (assessed by microcomputed tomography) were increased at 14 wk of age by 30% (P=0.02) and 38% (P=0.0009), respectively. Similar, nonsignificant trends were observed at 8 and 22 wk of age. Biomechanical testing showed lower bone fragility and reduced cortical hardness at 14 wk. We conclude that adiponectin stimulates osteoblast growth but inhibits osteoclastogenesis, probably via an effect on stromal cells. However, the AdKO mouse has increased bone mass, suggesting that adiponectin also has indirect effects on bone, possibly through modulating growth factor action or insulin sensitivity. Because adiponectin does influence bone mass in vivo, it is likely to be a contributor to the fat-bone relationship. Copyright © 2009 by The Endocrine Society.link_to_subscribed_fulltex