State of design report 2

In our first State of Design Report we asked our researchers whether, as the UK Design Council asserts, design always has an answer? In this second report we ask again whether design has any answers, or are there just questions? In Cedric Price’s lecture and slide show – “Technology is the answer but what was the question?” – technology is undoubtedly an answer but what the question might have been is a riddle . When, in the final paragraph, he says “The usefulness of this architecture is to remind its users that the major resource that should be conserved is the human spirit.” it is possible that if technology is the answer then the question might have been how to conserve the human spirit? Sixty years on…what might that mean? Design education is premised on the promise of making things better mostly on the slippery project of the better world. While the question about the better world remains ‘what kind of word do I want to live in?’ the answer remains elusive. Even Herbert Simon’s acclaimed ‘preferred state’ is just another way to imagine a better world. But continuing to believe in foretelling possible future scenarios and preferred states that seem to be less and less attainable might illustrate the uselessness of knowing the answers to the wrong questions

In Vitro Fermentation of NUTRIOSE® FB06, a wheat dextrin soluble fibre, in a continuous culture human colonic model system

Wheat dextrin soluble fibre may have metabolic and health benefits, potentially acting via mechanisms governed by the selective modulation of the human gut microbiota. Our aim was to examine the impact of wheat dextrin on the composition and metabolic activity of the gut microbiota. We used a validated in vitro three-stage continuous culture human colonic model (gut model) system comprised of vessels simulating anatomical regions of the human colon. To mimic human ingestion, 7 g of wheat dextrin (NUTRIOSE® FB06) was administered to three gut models, twice daily at 10.00 and 15.00, for a total of 18 days. Samples were collected and analysed for microbial composition and organic acid concentrations by 16S rRNA-based fluorescence in situ hybridisation and gas chromatography approaches, respectively. Wheat dextrin mediated a significant increase in total bacteria in vessels simulating the transverse and distal colon, and a significant increase in key butyrate-producing bacteria Clostridium cluster XIVa and Roseburia genus in all vessels of the gut model. The production of principal short-chain fatty acids, acetate, propionate and butyrate, which have been purported to have protective, trophic and metabolic host benefits, were increased. Specifically, wheat dextrin fermentation had a significant butyrogenic effect in all vessels of the gut model and significantly increased production of acetate (vessels 2 and 3) and propionate (vessel 3), simulating the transverse and distal regions of the human colon, respectively. In conclusion, wheat dextrin NUTRIOSE® FB06 is selectively fermented in vitro by Clostridium cluster XIVa and Roseburia genus and beneficially alters the metabolic profile of the human gut microbiota

Brutalisation as a Survival Strategy: How the 'Islamic State' Is Prolonging Its Doomsday Battle

The recent bomb attacks at the Istanbul airport (28 June 2016), in a tourist cafe in Dhaka, Bangladesh (2 July), and in Bagdad (3 July) were part of a "Ramadan campaign" announced by the spokesman of the self-declared 'Islamic State' caliphate in late May 2016. This series of attacks was intended to make the Islamic holy month of Ramadan "a month of calamity everywhere for the non-believers." It has generated significant international attention for an organisation which has recently lost the cities of Ramadi and Falluja in Iraq and which is under serious pressure in the strategic city of Manbij in Syria. This article analyses the Islamic State's (IS) contextual use of different forms of violence and argues that the attacks and the defeats are two sides of one coin: the group is losing territory and credibility by failing to continue with its expansion of the universal Islamic caliphate that "Caliph" Abu Bakr promised in summer 2014; it is now compensating for these territorial losses by expanding its field of action through terrorist attacks, thereby suggesting a fictitious expansion. The article explains how the group has exhibited a three-stage "cycle of violence" in which violence has served specific functions. In the first stage, from roughly 2003 to 2010, violence was used as part of a mobilisation strategy. In the second stage, from 2010 to 2015, violence served mainly to facilitate the group's expansion and rule. In the third stage, which began in 2015, the increasingly brutal violence and the fictitious expansion have constituted the centrepiece of a survival strategy. Against this background, the article suggests that the Islamic State will most likely not have a future as a territorial entity but will, at best, survive as a terrorist apocalyptic sect

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study

BACKGROUND: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the most recent definition. Our primary objective was to describe the natural course and the factors associated with worsening and mortality in this population. METHODS: This study analyzed patients from the international prospective Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) who had initial mild acute respiratory distress syndrome in the first day of inclusion. This study defined three groups based on the evolution of severity in the first week: "worsening" if moderate or severe acute respiratory distress syndrome criteria were met, "persisting" if mild acute respiratory distress syndrome criteria were the most severe category, and "improving" if patients did not fulfill acute respiratory distress syndrome criteria any more from day 2. RESULTS: Among 580 patients with initial mild acute respiratory distress syndrome, 18% (103 of 580) continuously improved, 36% (210 of 580) had persisting mild acute respiratory distress syndrome, and 46% (267 of 580) worsened in the first week after acute respiratory distress syndrome onset. Global in-hospital mortality was 30% (172 of 576; specifically 10% [10 of 101], 30% [63 of 210], and 37% [99 of 265] for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively), and the median (interquartile range) duration of mechanical ventilation was 7 (4, 14) days (specifically 3 [2, 5], 7 [4, 14], and 11 [6, 18] days for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively). Admissions for trauma or pneumonia, higher nonpulmonary sequential organ failure assessment score, lower partial pressure of alveolar oxygen/fraction of inspired oxygen, and higher peak inspiratory pressure were independently associated with worsening. CONCLUSIONS: Most patients with initial mild acute respiratory distress syndrome continue to fulfill acute respiratory distress syndrome criteria in the first week, and nearly half worsen in severity. Their mortality is high, particularly in patients with worsening acute respiratory distress syndrome, emphasizing the need for close attention to this patient population.status: publishe