Exploring environmental urban policies: a methodological proposal to build a composite indicator measuring urban environmental virtuosity

Synthesizing the complex phenomenon of “environment” into a single indicator could leads to a loss of information, which inhibit his use as a reference for the resolution of several issues such as, for example, the allocation of resources. On the other hand it allows to represent the overall environmental performance of cities and to highlight relationships between different sectors. We consider “process oriented” variables instead of aggregated and “outcome oriented” ones, generally used to measure environmental sustainability strictu sensu. In this sense we refers specifically to the concept of “environmental virtuosity”, that allows to rank statistical units (i.e. Italian main municipalities), considering their policy efforts for improving urban environmental quality. Generally an indicator of environmental quality should combine partial information to summarize the main subject. This paper proposes to measure urban environmental virtuosity by multivariate analysis, following OECD (2008) procedure. This methodology will try to overcome the main methodological issues in building up indicators, consisting in the choice of weights and in the common practice of simply adding sub-indicators.Composite indicators, multivariate analysis, environmental policies

Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights and Therapeutic Applications

Hematopoiesis is the process of blood cell formation starting from hematopoietic stem/progenitor cells (HSPCs). The understanding of regulatory networks involved in hematopoiesis and their impact on gene expression is crucial to decipher the molecular mechanisms that control hematopoietic development in physiological and pathological conditions, and to develop novel therapeutic strategies. An increasing number of epigenetic studies aim at defining, on a genome-wide scale, the cis-regulatory sequences (e.g., promoters and enhancers) used by human HSPCs and their lineage-restricted progeny at different stages of development. In parallel, human genetic studies allowed the discovery of genetic variants mapping to cis-regulatory elements and associated with hematological phenotypes and diseases. Here, we summarize recent epigenetic and genetic studies in hematopoietic cells that give insights into human hematopoiesis and provide a knowledge basis for the development of novel therapeutic approaches. As an example, we discuss the therapeutic approaches targeting cis-regulatory regions to reactivate fetal hemoglobin for the treatment of β-hemoglobinopathies. Epigenetic studies allowed the definition of cis-regulatory sequences used by human hematopoietic cells. Promoters and enhancers are targeted by transcription factors and are characterized by specific histone modifications. Genetic variants mapping to cis-regulatory elements are often associated with hematological phenotypes and diseases. In some cases, these variants can alter the binding of transcription factors, thus changing the expression of the target genes. Targeting cis-regulatory sequences represents a promising therapeutic approach for many hematological diseases. Stem Cells Translational Medicine 2017;6:2106â2114

Exploring environmental urban policies: a methodological proposal to build a composite indicator measuring urban environmental virtuosity

Synthesizing the complex phenomenon of “environment” into a single indicator could leads to a loss of information, which inhibit his use as a reference for the resolution of several issues such as, for example, the allocation of resources. On the other hand it allows to represent the overall environmental performance of cities and to highlight relationships between different sectors. We consider “process oriented” variables instead of aggregated and “outcome oriented” ones, generally used to measure environmental sustainability strictu sensu. In this sense we refers specifically to the concept of “environmental virtuosity”, that allows to rank statistical units (i.e. Italian main municipalities), considering their policy efforts for improving urban environmental quality. Generally an indicator of environmental quality should combine partial information to summarize the main subject. This paper proposes to measure urban environmental virtuosity by multivariate analysis, following OECD (2008) procedure. This methodology will try to overcome the main methodological issues in building up indicators, consisting in the choice of weights and in the common practice of simply adding sub-indicators

La selezione degli interventi in un piano regionale dei rifiuti speciali

EnL’evoluzione delle conoscenze, dei bisogni, delle tecnologie e delle disponibilità finanziarie porta a considerare il Piano Regionale dei Rifiuti Speciali, non come un atto deliberativo e ordinativo, bensì come un processo dinamico, per il quale risulta necessario individuare, di volta in volta, i principali nodi decisionali e ricercare le soluzioni con il supporto di adeguate tecniche di valutazione. Tenuto conto della natura fortemente multidimensionale del problema decisionale, caratterizzato dalla presenza di obiettivi molto differenziati riconducibili ad un’ampia nozione di sostenibilità ambientale, oltre che economico finanziaria, si ritiene opportuno proporre, per la generazione, valutazione e selezione di differenti scenari di piano, un approccio valutativo di tipo multicriteriale che consenta di trasformare il problema decisionale multiobiettivo e multidimensionale in un problema di ottimizzazione vincolata monobiettivo

Environmental fiscal reform and willingness to pay for the environment: an empirical analysis on European micro data

This paper empirically investigates the determinants of willingness to pay (WTP) for the environment, employing micro data from the European Value Survey (EVS) over 2008-2010 in 27 European countries. Using ordered logit, logit and partially constrained generalized ordered logit models, we explore a wide set of individual and country level determinants. Our particular focus is on whether WTP is influenced by the Environmental Fiscal Reforms (EFR), carried out only in some countries of our sample. Our results show that WTP for the environment is lower in countries where an Environmental Fiscal Reform has been introduced. Moreover, analyses conducted on the role of information highlight that being presumably aware of the environmental fiscal reform does not affect positively the marginal willingness to pay for the environment

Environmental fiscal reform and willingness to pay for the environment: an empirical analysis on European micro data

This paper empirically investigates the determinants of willingness to pay (WTP) for the environment, employing micro data from the European Value Survey (EVS) over 2008-2010 in 27 European countries. Using ordered logit, logit and partially constrained generalized ordered logit models, we explore a wide set of individual and country level determinants. Our particular focus is on whether WTP is influenced by the Environmental Fiscal Reforms (EFR), carried out only in some countries of our sample. Our results show that WTP for the environment is lower in countries where an Environmental Fiscal Reform has been introduced. Moreover, analyses conducted on the role of information highlight that being presumably aware of the environmental fiscal reform does not affect positively the marginal willingness to pay for the environment

Storia e caratteristiche del progetto multicentrico di ricerca "International Self - Report Delinquency Study": il contributo della Criminologia italiana

The present paper reviews the history, the principal characteristics, the recent evolutions and the objectives of the international multi-centric study on juvenile self-report delinquency and victimization called ISRD, and describes the contribution of Italian criminology to the project. The most important international results of the first two waves of the research (ISRD 1 and ISRD2), and the innovations introduced in the planning of the third wave (ISRD3) are also described: The collection of data has been concluded in Italy, but not in all the 35 countries participating to the study