A Clinical Analysis of 26 Cases with Non-Gynecologic Metastatic Tumors of the Ovary

OBJECTIVE: To review 26 cases of nongynecologic metastatic ovarian tumors with respect to primary origin and their clinical features were reviewed. STUDY DESIGN: During 60 months period, we had 274 cases of malignant ovarian tumors of which 26 (9,5 %) were nongynecologic metastatic carcinoma. RESULTS: Mean age of the 26 cases was 46,4 years. Primary sites were stomach (42,3 %), colon (42,3 %), appendix (11,5 %) and breast (3,8 %). Tumor was demonstrated to involve both ovaries in 16 cases (61,5 %). Fourteen of the metastatic tumors were histologically determined to be Krukenberg tumor. All cases underwent laparotomy, seven cases with malign cytology had chemotherapy before operation. Prognosis was poor, 18 cases died in 3 years, 8 cases are still under treatment and follow up. CONCLUSIONS: In cases of ovarian tumors, metastatic tumors should be considered in the differential diagnosis

Prognostic Significance of Preterm Isolated Decreased Fetal Movement

Objective: Our aim is to evaluate the prognostic significance of isolated, preterm decreased fetal movement following normal initial full diagnostic workup. Study design: A retrospective observational study was conducted at a tertiary centre. The applied protocol was approved by the Medical Research Ethics Department of the hospital where the research was conducted. Obstetrics outcomes of preterm- and term-decreased fetal movement were compared following an initial, normal diagnostic work up. Evaluated outcomes were birth weight, mode of delivery, stillbirth rate, induction of labour, development of gestational hypertension, small for gestational age and oligohydramnios, polyhydramnios during the follow up period. Result: Obstetric complications related to placental insufficiency develops more frequently for decreased fetal movement in preterm cases with respect to that of in term cases. Following the diagnosis of decreased fetal movement, pregnancy hypertension occurred in 17% of preterm decreased fetal movement cases and in 4.7% of term decreased fetal movement cases. Fetal growth restriction developed in 6.6% of preterm decreased fetal movement and in 2.3% of term decreased fetal movement. Amniotic fluid abnormalities more frequently developed in preterm decreased fetal movement. Conclusion: Following an initial normal diagnostic workup, preterm decreased fetal movement convey a higher risk for the development of pregnancy complications associated with placental insufficiency. The patient should be monitored closely and management protocols must be developed for initial normal diagnostic workups in cases of preterm decreased fetal movement

Elastosonographic Evaluation of Endometrium in Postmenopausal Bleeding

OBJECTIVE: The aim of this study was to evaluate the elastosonographic changes of endometrium in postmenopausal women with uterine bleeding. STUDY DESIGN: A total of 80 women in their postmenopausal period were enrolled for the study; 19 with postmenopausal bleeding and 61 normal healthy controls. All patients with a history of previous uterine surgery (including myomectomy) and/or endometrial interventions such as endometrial ablation, polyp removal, hysteroscopic interventions (except solely diagnostic procedures) and endometrial sampling within one year were excluded from the study because of the possibility of endometrial changes that may interfere with elastosonographic starin ratios. B-mode scanning, Doppler and real-time tissue elastography (RTE) were performed by the same single operator, blinded to the study design. The ultrasonographic findings (strain ratio, endometrial thickness, uterine artery Doppler indices) were evaluated between groups. RESULTS: The means of age were 57.84±5.36 years and 56.34±3.32 years for the study group and the controls respectively. The groups were similar in regard to age (p=0.328). The parity of the postmenopausal bleeding group was significantly higher than the controls (p<0.001). When uterine artery Doppler indices were compared between groups, study group was found to have lower values in regard to controls (p<0.001). The medians of endometrial thickness were 4.30 (IQR=3.80)mm in the study group and 2.60 (IQR=0.90) mm in the control group and the difference was found to be significant (p<0.001). The medians of elastosonographic B/A ratios were 0.98 (IQR=0.18) and 1.27 (IQR=1.78) for the study group and controls respectively. The B/A ratios were found to be significantly lower in the study group (lower tissue elasticity) (p<0.001). CONCLUSION: Tissue biopsy for histopathologic evaluation is still the gold standart in cases with postmenopausal bleeding. However, the need for a noninvasive method with high sensitivity and specificity is still under search. Some women who had been offered biopsy but did not accept the intervention because of the invasive nature of the procedure will be eft undiagnosed for a possible malignancy. Evaluation of the endometrium with real-time tissue elastosonography is one of the noninvasive methods with this potential and the diagnostic value of RTE could be possible with multicentric studies including more subjects