Detection of two new RRATs at 111 MHz

A search for pulse signals in a area with declinations of +52\degr <\delta <+55\degr was carried out on the LPA LPI radio telescope. When processing ten months of observations recorded in six frequency channels with a channel width of 415 kHz and a total bandwidth of 2.5 MHz, 22 thousand events were found with a pronounced dispersion delay of signals over frequency channels, i.e. having signs of pulsar pulses. It turned out that the found pulses belong to four known pulsars and two new rotating radio transients (RRATs). An additional pulse search conducted in 32-channel data with a channel width of 78 kHz revealed 8 pulses for the transient J0249+52 and 7 pulses for the transient J0744+55. Periodic radiation of transients was not detected. The analysis of observations shows that the found RRATs are most likely pulsars with nullings, where the proportion of nulling is greater than 99.9\%.Comment: published in Astronomy Reports, translated by Yandex translator with correction of scientific lexis, 5 pages, 2 figures, 1 tabl

Proton configurations in the hydrogen bonds of KH2PO4 as seen by resonant x-ray diffraction

KH2PO4 (KDP) belongs to the class of hydrogen-bonded ferroelectrics, whose paraelectric to ferroelectric phase transition is driven by the ordering of the protons in the hydrogen bonds. We demonstrate that forbidden reflections of KDP, when measured at an x-ray absorption edge, are highly sensitive to the asymmetry of proton configurations. The change of average symmetry caused by the "freezing" of the protons during the phase transition is clearly evidenced. In the paraelectric phase, we identify in the resonant spectra of the forbidden reflections a contribution related to the transient proton configurations in the hydrogen bonds, which violates the high average symmetry of the sites of the resonant atoms. The analysis of the temperature dependence reveals a change of relative probabilities of the different proton configurations. They follow the Arrhenius law, and the activation energies of polar and Slater configurations are 18.6 and 7.3 meV, respectively

Multifrequency Study of Giant Radio Pulses from the Crab Pulsar with the K5 VLBI Recording Terminal

Simultaneous multifrequency observations of the Crab pulsar giant pulses (GPs) were performed with the 64-m Kalyazin radio telescope at four frequencies 0.6, 1.4, 2.2 and 8.3 GHz using the K5 VLBI recording terminal. The K5 terminal provided continuous recording in 16 4-MHz wide frequency channels distributed over 4 frequency bands. Several thousands of GPs were detected during about 6 hours of observations in two successive days in July 2005. Radio spectra of single GPs were analysed at separate frequencies and over whole frequency range. These spectra manifest notable modulation over frequency ranges, $\Delta\nu$, both on large ($\Delta\nu/\nu\approx 0.5$) and small ($\Delta\nu/\nu\approx 0.01$) frequency scales. Cross-correlation analysis of GPs at 2.2 GHz showed that their pulse shapes can be interpreted as an ensemble of unresolved bursts grouped together at time scales of $\approx 1$ mcs being well-correlated over a 60-MHz band. The corresponding GP cross-correlation functions do not obey the predictions of the amplitude-modulated noise model of Rickett (1975), thus indicating that unresolved components represent a small number of elementary emitters.Comment: 22 pages, 11 figures, 3 tables, submitted to PAS

Detection of Five New RRATs at 111 MHz

Results of 111-MHz monitoring observations carried out on the Big Scanning Antenna of the Pushchino Radio Astronomy Observatory during September 1-28, 2015 are presented. Fifty-four pulsating sources were detected at declinations $-9^o < \delta < +42^o$. Forty-seven of these are known pulsars, five are new sources, and two are previously discovered transients. Estimates of the peak flux densities and dispersion measures are presented or all these sources.Comment: published in Astronomy Report, translated by Yandex translator with correction of scientific lexis, 8 pages, 2 figures, 3 table

Giant Pulses -- the Main Component of the Radio Emission of the Crab Pulsar

The paper presents an analysis of dual-polarization observations of the Crab pulsar obtained on the 64-m Kalyazin radio telescope at 600 MHz with a time resolution of 250 ns. A lower limit for the intensities of giant pulses is estimated by assuming that the pulsar radio emission in the main pulse and interpulse consists entirely of giant radio pulses; this yields estimates of 100 Jy and 35 Jy for the peak flux densities of giant pulses arising in the main pulse and interpulse, respectively. This assumes that the normal radio emission of the pulse occurs in the precursor pulse. In this case, the longitudes of the giant radio pulses relative to the profile of the normal radio emission turn out to be the same for the Crab pulsar and the millisecond pulsar B1937+21, namely, the giant pulses arise at the trailing edge of the profile of the normal radio emission. Analysis of the distribution of the degree of circular polarization for the giant pulses suggests that they can consist of a random mixture of nanopulses with 100% circular polarization of either sign, with, on average, hundreds of such nanopulses within a single giant pulse.Comment: 13 pages, 6 figures (originally published in Russian in Astronomicheskii Zhurnal, 2006, vol. 83, No. 1, pp. 62-69) translated by Denise Gabuzd

Effects of central administration of the human Tau proteinon the <i>Bdnf, Trkb, p75, Mapt, Bax</i> and <i>Bcl-2</i> genes expression in the mouse brain

Alzheimer’s disease is the most common form of dementia, affecting millions of people worldwide. Despite intensive work by many researchers, the mechanisms underlying Alzheimer’s disease development have not yet been elucidated. Recently, more studies have been directed to the investigation of the processes leading to the formation of neurofibrillary tangles consisting of hyperphosphorylated microtubule-associated Tau proteins. Pathological aggregation of this protein leads to the development of neurodegeneration associated with impaired neurogenesis and apoptosis. In the present study, the effects of central administration of aggregating human Tau protein on the expression of the Bdnf, Ntrk2, Ngfr, Mapt, Bax and Bcl-2 genes in the brain of C57Bl/6J mice were explored. It was found that five days after administration of the protein into the fourth lateral ventricle, significant changes occurred in the expression of the genes involved in apoptosis and neurogenesis regulation, e. g., a notable decrease in the mRNA level of the gene encoding the most important neurotrophic factor BDNF (brain-derived neurotrophic factor) was observed in the frontal cortex which could play an important role in neurodegeneration caused by pathological Tau protein aggregation. Central administration of the Tau protein did not affect the expression of the Ntrk2, Ngfr, Mapt, Bax and Bcl-2 genes in the frontal cortex and hippocampus. Concurrently, a significant decrease in the expression of the Mapt gene encoding endogenous mouse Tau protein was found in the cerebellum. However, no changes in the level or phosphorylation of the endogenous Tau protein were observed. Thus, central administration of aggregating human Tau protein decreases the expression of the Bdnf gene in the frontal cortex and the Mapt gene encoding endogenous mouse Tau protein in the cerebellum of C57Bl/6J mice

Clinical study a Small-bowel mucosal transglutaminase 2-specific IgA deposits for the Diagnostics and efficiency in treatment of Celiac disease - results and conclusion

In this study is investigated transglutaminase-2 specific mucosal IgA autoantibody deposits which determined from small-bowel mucosal biopsies in 18 untreated, 18 treated celiac disease patients and in 40 nonceliac controls. The presence of the deposits was compared with mucosal villous morphology celiac, serology and genetic markers. The analysis of results has shown high diagnostic efficiency of discovering subepithelial deposits mucosal transglutaminase-2 specific IgA autoantibody in the diagnostics and dietary monitoring of this disorderПредставлены исследования по определению субэпителиальных депозитов тканевых трансглутаминазных антител (IgA-tTG) в биоптатах слизистой оболочки тонкого кишечника у пациентов в разных группах: впервые выявленная целиакия (18), больные целиакией, находящиеся на лечении (18) и пациенты без целиакии (40). Все пациенты, одновременно с субэпителиальными депозитами тканевых трансглутаминазных антител, прошли обследование на сывороточные, генетические и гистологические маркеры. Использование данного метода показало высокую диагностическую эффективность выявления субэпителиальных депозитов тканевых трансглутаминазных антител IgA-tTG для диагностики целиакии и мониторинга патогенетической диетотерапии

MEAT PRODUCTION IN RUSSIA: PROBLEMS OF IMPORT SUBSTITUTION

This article provides a feasibility study of the State program of agricultural development and regulation of agricultural products, raw materials and food for 2013-2020 in terms of production and import of meat products. To analyze the feasibility of the said State program has been used three tools: trend analysis of the key indicators, statistical regression analysis and production function. Proposed methodological approach and tools for expert evaluation of realizability of the State Program allowed us to determine its possible unrealizability as scheduled until 2020