Heavy Metal Accumulation in Sediment and Removal Efficiency in the Stabilization Ponds with the Hydrocotyle ranunculoides Filter

The heavy metal accumulation in the sediment and removal efficiency in stabilization ponds with Hydrocotyle ranunculoides filter were evaluated. Sediment and water were sampled in June, July and August 2018. The sediment sampling for each lagoon was conducted at three sites forming a composite sample. The water samples were collected in the tributary and effluent pipelines to determine the heavy metal concentration and removal efficiency by Hydrocotyle ranunculoides. The determination of heavy metals was performed with the method of atomic flame absorption spectrophotometry. The mean concentration of heavy metals in the sediment, in a descending order, was: Fe > Zn > Pb > Cu > Cd. The concentrations of these metals ranged from 998.0 to 1365.02, from 488.01 to 600.30, from 88.23 to 95.01, from 1.47 to 1.53 and from 0.01 to 0.13 mg/Kg, respectively. In the four stabilization ponds, the pollution factor values for Cd, Cu and Fe qualified as low pollution factor. While for Zn and Pb, they qualified as moderate pollution factors. The heavy metal removal rates from the water varied by metal

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele