"Peace, toleration and decay: the ecclesiology of later Stuart dissent" by Martin Sutherland

Review of Martin Sutherland, Peace, Toleration and Decay: The Ecclesiology of Later Stuart Dissent (Carlisle: Paternoster, 2003)Publisher PD

Sociosexual Norms, The Behavioural Immune System Hypothesis And The Red Queen

Pathogen pressure has played an extremely influential role in human adaptive evolution. It is well established that this role includes extensive selective sweeps upon the genetic substrates of antibody repertoires. A growing volume of research suggests that this role may extend to the evolution of sophisticated cognitive mechanisms via which individuals detect and avoid initial infection. In humans, such mechanisms may play an influential role in the emergence, establishment and reinforcement of cultural norms of behaviour. This is termed the behavioural immune system hypothesis. Sexual behaviour, which represents a significant potential route to infection, is the subject of widely differing attitudes and norms throughout the world. Herein, it is hypothesised that norms of restrictiveness may tend to vary along gradients of pathogen prevalence. It is further hypothesised that differential fitness costs between the sexes, arising from pathogen stress, may contribute towards explaining the existence of differing levels of sexual permissiveness. To account for the contingency that the results yielded track in the opposite to that which is hypothesised, the Red Queen hypothesis (wherein the faster adaptive rate of pathogens predicts a preference for genetic diversity – and thus less restrictive social norms) is put forth as a counterpoint. Improved characterisation of the biocultural basis of differing sexual norms promises to provide insights useful in anthropological research, as well as public health planning and risk mitigation

"Peace, Toleration and Decay: The Ecclesiology of Later Stuart Dissent" by Martin Sutherland

Review ofMartin Sutherland, Peace, Toleration and Decay: The Ecclesiology of Later Stuart Dissent (Carlisle: Paternoster, 2003

Farmers’ perception about quality of planted seed yam and their preferences for certified seed yam in Ghana

The study examined the effect of farmers’ perception about the quality of seed yam typically used for cultivation on their preferences for certified seed yam. Heckman’s sample selectivity probit model was applied on survey data collected from 380 yam farmers. The study found that farmers generally agree that the use of certified seed yam would help to improve yield because of minimum to no disease/pest infestation. Farmers expressed their willingness to purchase certified seed yam if the price is about 26% higher than those supplied from the informal system in as much as the quality can be assured. The study found that farmer educational level, experience, access to extension services and household incomes were factors influencing farmers’ perception about quality of seed yam cultivated. Variables such as age, educational level and income were also found to be factors that influence farmers’ preference for certified seed yam. The results were similar for both Pona and other white yam varieties. The study recommends promotion of farmer education through increased access to extension services on seed quality assessment together with other agronomic practices including farmer field schools, to help improve their ability to assess the quality of seed yam obtained from other sources as well as increase their preference for certified seed yam

Performance of steer progeny of sires differing in genetic potential for fatness and meat yield following post-weaning growth at different rates.: 1. Growth and live-animal composition

The present experiment, 'Regional Combinations', examined growth, and carcass- and meat-quality traits in the progeny of sires genetically diverse for fatness and meat yield when grown at different rates from weaning to feedlot entry. The present paper is the first of several papers describing results from the New South Wales site, one of four in the project. It reports the effects on growth and body composition of steers during backgrounding and feedlot finishing phases. A total of 43 sires within three carcass-class categories, defined as high potential for meat yield, for marbling or for both traits, was used, based on estimated breeding values for retail beef yield and intramuscular fat. Sires were drawn from Angus, Charolais, Limousin, Black Wagyu and Red Wagyu breeds, providing a range of carcass sire types across the three carcass classes. Matings were by artificial insemination to Hereford dams from a single herd. Steer progeny were grown at conventional (slow: ~0.5 kg/day) or accelerated (fast: ~0.7 kg/day) rates from weaning to feedlot entry weight, targeting group means of 400 kg. Accelerated and conventionally grown groups from successive calvings entered the feedlot at similar entry liveweights at the same time, then having identical management during the 100-day finishing phase before slaughter. Within finishing cohorts, fast backgrounding growth resulted in increased subcutaneous fatness at feedlot entry in steers of all carcass types. Slow growth during backgrounding resulted in faster (compensatory) growth in the feedlot in all classes and sire types. This increased the deposition of fat in slow-backgrounded steers compared with that in fast-backgrounded steers during feedlotting, and thus reduced the difference between the groups in P8 and rib fat at feedlot exit. However, there did appear to be an advantage in the level of compensation in the feedlot in favour of those sire types with a genetic propensity for faster growth. Backgrounding growth rate affected body composition and the rate of weight gain during finishing. Faster growth produced more subcutaneous fat during both backgrounding and finishing. Steer progeny groups clearly showed the expected responses in growth and body composition, on the basis of the genetic potential of their sires

Performance of steer progeny of sires differing in genetic potential for fatness and meat yield following postweaning growth at different rates.: 2. Carcass traits

The steer progeny of sires genetically diverse for fatness and meat yield were grown at different rates from weaning to feedlot entry and effects on growth, carcass and meat-quality traits were examined. The present paper, the second of a series, reports the effects of genetic and growth treatments on carcass traits. A total of 43 sires, within three 'carcass class' categories, defined as high potential for meat yield, marbling or both traits, was used. Where available, estimated breeding values for the carcass traits of retail beef yield (RBY%) and intramuscular fat (IMF%) were used in selection of the sires, which were drawn from Angus, Charolais, Limousin, Black Wagyu and Red Wagyu breeds, to provide a range of carcass sire types across the three carcass classes. Steer progeny of Hereford dams were grown at either conventional (slow: ~0.5 kg/day) or accelerated (fast: ~0.7 kg/day) rates from weaning to feedlot entry weight, with group means of ~400 kg. Accelerated and conventionally grown groups from successive calvings were managed to enter the feedlot at similar mean feedlot entry weights at the same time for the 100-day finish under identical conditions. Faster-backgrounded groups had greater fat levels in the carcass than did slower-backgrounded groups. Dressing percentages and fat colour were unaffected by growth treatment, whereas differences in ossification score and meat colour were explained by age at slaughter. There were significant effects of sire type for virtually all carcass traits measured in the progeny. Differences in hot standard carcass weight showed a clear advantage to European types, with variable outcomes for the Angus and Wagyu progeny. Sire selection by estimated breeding values (within the Angus breed) for yield and/or fat traits resulted in expected differences in the progeny for those traits. There were large differences in both meat yield and fatness among the types of greatest divergence in genetic potential for those traits, with the Black Wagyu and the Angus IMF clearly superior for IMF%, and the European types for RBY%. The Angus IMF progeny performed as well as that of the Black Wagyu for all fatness traits. Differences in RBY% among types were generally reflected by similar differences in eye muscle area. Results here provide guidelines for selecting sire types to target carcass traits for specific markets. The absence of interactions between growth and genetic treatments ensures that consistent responses can be expected across varying management and production systems

PET Imaging a MPTP-Induced Mouse Model of Parkinson’s Disease Using the Fluoropropyl-Dihydrotetrabenazine Analog [18F]-DTBZ (AV-133)

Parkinson’s disease (PD) is characterized by the loss of dopamine-producing neurons in the nigrostriatal system. Numerous researchers in the past have attempted to track the progression of dopaminergic depletion in PD. We applied a quantitative non-invasive PET imaging technique to follow this degeneration process in an MPTP-induced mouse model of PD. The VMAT2 ligand 18F-DTBZ (AV-133) was used as a radioactive tracer in our imaging experiments to monitor the changes of the dopaminergic system. Intraperitoneal administrations of MPTP (a neurotoxin) were delivered to mice at regular intervals to induce lesions consistent with PD. Our results indicate a significant decline in the levels of striatal dopamine and its metabolites (DOPAC and HVA) following MPTP treatment as determined by HPLC method. Images obtained by positron emission tomography revealed uptake of 18F-DTBZ analog in the mouse striatum. However, reduction in radioligand binding was evident in the striatum of MPTP lesioned animals as compared with the control group. Immunohistochemical analysis further confirmed PET imaging results and indicated the progressive loss of dopaminergic neurons in treated animals compared with the control counterparts. In conclusion, our findings suggest that MPTP induced PD in mouse model is appropriate to follow the degeneration of dopaminergic system and that 18F-DTBZ analog is a potentially sensitive radiotracer that can used to diagnose changes associated with PD by PET imaging modality

Improving response rates using a monetary incentive for patient completion of questionnaires: an observational study

Background: Poor response rates to postal questionnaires can introduce bias and reduce the statistical power of a study. To improve response rates in our trial in primary care we tested the effect of introducing an unconditional direct payment of 5 pound for the completion of postal questionnaires. Methods: We recruited patients in general practice with knee problems from sites across the United Kingdom. An evidence-based strategy was used to follow-up patients at twelve months with postal questionnaires. This included an unconditional direct payment of 5 pound to patients for the completion and return of questionnaires. The first 105 patients did not receive the 5 pound incentive, but the subsequent 442 patients did. We used logistic regression to analyse the effect of introducing a monetary incentive to increase the response to postal questionnaires. Results: The response rate following reminders for the historical controls was 78.1% ( 82 of 105) compared with 88.0% ( 389 of 442) for those patients who received the 5 pound payment (diff = 9.9%, 95% CI 2.3% to 19.1%). Direct payments significantly increased the odds of response ( adjusted odds ratio = 2.2, 95% CI 1.2 to 4.0, P = 0.009) with only 12 of 442 patients declining the payment. The incentive did not save costs to the trial - the extra cost per additional respondent was almost 50 pound. Conclusion: The direct payment of 5 pound significantly increased the completion of postal questionnaires at negligible increase in cost for an adequately powered study

1.5 {\mu}m Epitaxially Regrown Photonic Crystal Surface Emitting Laser Diode

We present an InP-based epitaxially regrown photonic crystal surface emitting laser diode, lasing in quasi- CW conditions at 1523nm.Comment: 4 pages, 5 figures, journal submission for revie

Health-related quality of life in mucopolysaccharidosis : looking beyond biomedical issues

The mucopolysaccharidoses (MPS) comprise a heterogeneous family of rare, genetic lysosomal storage disorders that result in severe morbidity and reduced life expectancy. Emerging treatments for several of these disorders have triggered the search for clinically relevant biomarkers and clinical markers associated with treatment efficacy in populations and individuals. However, biomedical measures do not tell the whole story when characterizing a complex chronic disorder such as MPS. Health-related quality of life (HRQoL) tools that utilize patient reported outcomes to address patient parameters such as symptoms (pain, fatigue, psychological health), functioning (activity and limitations), or quality of life, have been used to supplement traditional biomedical endpoints. Many of these HRQoL tools have demonstrated that quality of life is negatively impacted in patients with MPS. There is both the opportunity and need to formally standardize and validate HRQoL tools for the different MPS disorders.Additional file 1: Table S1. Classification of MPS.Additional file 2: Patient-reported outcome (PRO) measures used in mucopolysaccharidosis (MPS) studies.BioMarin Pharmaceuticals Ltd.http://www.ojrd.comam2016Paediatrics and Child Healt