1-Tetralinyl as Carboxamide-Protecting Group for Asparagine and Application to N-alpa- t-Butyloxycarbonyl (Boc) Solid-phase Peptide Synthesis of Oxytocin

Oxytocin, a nonapeptide amide, was synthesized on a benzhydryl-resin using the Boc strategy. Benzyl group was used in the protection of sulfhydryl group of cysteine and tyrosine side-chain. Benzhydryl and tetralinyl groups were used in the protection of glutamine and asparagine side-chains respectively. TFMSA-TFA-thioanisole-1,2-ethanedithiol (2:20:2:1 v/v) was used on the peptide-resin under different cleavage conditions to obtain oxytocin in a one-pot reaction. The cleavage at 40°C for two hours gave oxytocin quantitatively. Oxytocin could be isolated in 56% yield. Keywords: Boc-strategy, Solid-phase peptide Synthesis, nonapeptide, resin, protecting grou

Solid-Phase Peptide Synthesis of Arginine-vasopressin with Amide Side-chain of Asparagine Protected with 1-Tetralinyl Group

Arginine-vasopressin, a nonapeptide amide, was synthesized on a benzhydryl-resin using the Boc-strategy. Benzyl group was used in the protection of sulfhydryl group of cysteine and tyrosine side-chain. Benzhydryl, tetralinyl and tosyl groups were used in the protection of glutamine, asparagine and arginine side-chains respectively. TFMSA-TFA-thioanisole-1,2-ethanedithiol (2:20:2:1 v/v) was used to cleave the peptide from  the resin under different conditions to obtain arginine-vasopressin in a one-pot reaction. The cleavage at 40°C for two hours gave arginine-vasopressin quantitatively (77% yield) Keywords: Solid-Phase Peptide Synthesis, resin, protecting group, cleavage, nonapeptide

Electrochemical characteristics of polyaniline electropolymerized on a 'phenol' modified carbon electrode

BuII. Chem. Soc. Ethiop., 5(1), 27-31 (1991)

Effect of pyridine on the porosity and redox properties of polythiophene

Bull. Chem. Soc. Ethiop., 3(1), 41-45 (1989)

Electro-oxidation of ascorbic acid on a polyaniline coated electrode

Bull. Chem. Soc. Ethiop., 4(2), 147-149 (1990)

Electrochemical characteristics of polyaniline electropolymerized on a 'phenol' modified carbon electrode

BuII. Chem. Soc. Ethiop., 5(1), 27-31 (1991)

Electro-oxidation of ascorbic acid on a polyaniline coated electrode

Bull. Chem. Soc. Ethiop., 4(2), 147-149 (1990)

Electrochemistry of polyaniline obtained from potentiostatic oxidation of aniline on polythiophene coated electrode

Bull. Chem. Soc. Ethiop., 3(2), 107-113 (1989)

Effect of pyridine on the porosity and redox properties of polythiophene

Bull. Chem. Soc. Ethiop., 3(1), 41-45 (1989)

Oxidation of ascorbic acid on a poly aniline modified electrode

BuII. Chem. Soc. Ethiop. 1993, 7(1) 53-60