Therapeutic Efficacy of Garlic Oil with 1,25 Dihydroxy Vit D and Calcium in Osteoporotic Ovariectomized Rats

Abstract: Objective: To investigate the therapeutic efficacy of synergestic effect of garlic oil, 1,25 dihydroxy vit-D3 and calcium in osteopenic ovariectomized rats. Materials and Methods: Forty female albino rats were used in the study. They fed a standard chow throughout the study. They were divided into 5groups: Sham operated control group (SH), ovariectomized group (OVX), OVX received garlic oil, OVX received combined drug of Ca and vit. D3 orally, and OVX coadministered with garlic oil, Ca+vit. D3. All the groups were tested for bone turnover parameters (serum osteocalcin and alkaline phosphatase), serum estradiol level and serum calcium & phosphorus. The excised femur bones were subjected for DEXA analysis. Results:In the OVX group mean serum calcium level was significantly decreased but improvement was obtained in the treated animal groups although the change was not statistically significant. Significant decrease in the mean serum estradiol level and significant increase in the mean serum levels of both osteocalcin and alkaline phosphatase were noticed in the OVX group compared to the SH control group. Significant improvement in all these parameters were obtained in the treated groups, but better improvement was obtained when garlic oil was combined with Ca and vit.D

Tuning electro-magnetic interference shielding efficiency of customized polyurethane composite foams taking advantage of rGO/Fe3O4 hybrid nanocomposites

Electromagnetic interference (EMI) has been recognized as a new sort of pollution and can be considered as the direct interference of electromagnetic waves among electronic equipment that frequently affects their typical efficiency. As a result, shielding the electronics from this interfering radiation has been addressed as critical issue of great interest. In this study, different hybrid nanocomposites consisting of magnetite nanoparticles (Fe3O4) and reduced graphene oxide (rGO) as (conductive/magnetic) fillers, taking into account different rGO mass ratios, were synthesized and characterized by XRD, Raman spectroscopy, TEM and their magnetic properties were assessed via VSM. The acquired fillers were encapsulated in the polyurethane foam matrix with different loading percentages (wt%) to evaluate their role in EMI shielding. Moreover, their structure, morphology, and thermal stability were investigated by SEM, FTIR, and TGA, respectively. In addition, the impact of filler loading on their final mechanical properties was determined. The obtained results revealed that the Fe3O4@rGO composites displayed superparamagnetic behavior and acceptable electrical conductivity value. The performance assessment of the conducting Fe3O4@rGO/PU composite foams in EMI shielding efficiency (SE) was investigated at the X-band (8–12) GHz, and interestingly, an optimized value of SE −33 dBw was achieved with Fe3O4@rGO at a 80:20 wt% ratio and 35 wt% filler loading in the final effective PU matrix. Thus, this study sheds light on a novel optimization strategy for electromagnetic shielding, taking into account conducting new materials with variable filler loading, composition ratio, and mechanical properties in such a way as to open the door for achieving a remarkable SE.Ministerio de Ciencia e Innovación | Ref. PID2020-113704RB-I00Xunta de Galicia | Ref. ED431G 2019/06Xunta de Galicia | Ref. IN607A 2018/5Xunta de Galicia | Ref. ED431C 2021/45Unión Europea-FEDER (Interreg V-A—España-Portugal) | Ref. 0245_IBEROS_1_EUnión Europea-FEDER (Interreg V-A—España-Portugal) | Ref. 0712_ACUINANO_1_EUnión Europea-FEDER (Interreg V-A—España-Portugal) | Ref. 0624_2IQBIONEURO_6_

Hypoglycemic Effect of Selected Herbal Extracts on Streptozotocin Induced Diabetic Rats

Abstract: This study was carried out to investigate the most effective compounds extracted from approved selected antidiabetic plants on control blood glucose, serum insulin, lipid profile level and protective effect against oxidative stress in streptozotocin induced diabetic rats. Method: 70 albino rats were divided into 7 groups 10 rats each. Group ² normal control, group Ï diabetic control, group Ø received essential onion oil (100mg/kg b.w. orally), group ²V received alkaloids of lupin (100mg/kg b.w. orally), group V, group V² received anthocyanins of cinnamon and mulberry respectively (16 mg/kg b.w. orally) and group VÏ received their combination together (58 mg/kg b.w. orally) for 21 days. At the end of experiment Blood glucose, insulin levels, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol were estimated. Oxidative stress biomarkers represented in the amount of thiobarbituric acid reactive substances (TBARS) and nitric oxide were determined. Liver and kidney removed for histopathological examination. Results: All isolated compound improved diabetes status but the most potent antidiabetic effect was observed in combination of all compounds. W hile onion essential oil had both antioxdiabetic and antioxidant effect. Conculsion: These results suggest that administration of the combined drug and essential onion oil used as antidiabetic agent and improved diabetic status

Consensus Guideline on the Management of Epilepsy in Egypt: A National Delphi Consensus Study

Abstract Objective In epilepsy, early diagnosis, accurate determination of epilepsy type, proper selection of antiseizure medication, and monitoring are all essential. However, despite recent therapeutic advances and conceptual reconsiderations in the classification and management of epilepsy, serious gaps are still encountered in day‐to‐day practice in Egypt as well as several other resource‐limited countries. Premature mortality, poor quality of life, socio‐economic burden, cognitive problems, poor treatment outcomes, and comorbidities are major challenges that require urgent actions to be implemented at all levels. In recognition of this, a group of Egyptian epilepsy experts met through a series of consecutive meetings to specify the main concepts concerning the diagnosis and management of epilepsy, with the ultimate goal of establishing a nationwide Egyptian consensus. Methods The consensus was developed through a modified Delphi methodology. A thorough review of the most recent relevant literature and international guidelines was performed to evaluate their applicability to the Egyptian situation. Afterward, several remote and live rounds were scheduled to reach a final agreement for all listed statements. Results Of 278 statements reviewed in the first round, 256 achieved ≥80% agreement. Live discussion and refinement of the 22 statements that did not reach consensus during the first round took place, followed by final live voting then consensus was achieved for all remaining statements. Significance With the implementation of these unified recommendations, we believe this will bring about substantial improvements in both the quality of care and treatment outcomes for persons with epilepsy in Egypt. Plain Language Summary This work represents the efforts of a group of medical experts to reach an agreement on the best medical practice related to people with epilepsy based on previously published recommendations while taking into consideration applicable options in resource‐limited countries. The publication of this document is expected to minimize many malpractice issues and pave the way for better healthcare services on both individual and governmental levels