15 research outputs found
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker – Preparation and reactivation of tabun and paraoxon-inhibited
No full textAcetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Fifteen new monooxime reactivators of acetyleholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). The known reactivators (pralidoxime, HI-6, obidoxime, K075, K203) and the new compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE. Monooxime reactivators were not able to exceed the best known compounds for tabun poisoning, but some of them did show reactivation comparable with known compounds for paraoxon poisoning. However, extensive differences were found by a SAR study for various substitutions on the non-oxime part of the reactivator molecule. (C) 2007 Elsevier Ltd. All rights reserved.</p
Synthesis, Molecular Structure, Spectral, Thermal, and DFT Studies of an Organic Crystal: 1-(benzo[d][1,3]dioxol-5-yl)-3-phenylprop-2-en-1-One
No full textA new nickel(II) complex with the thiosemicarbazone of quinoline-2-carboxaldehyde: structure, DNA-binding, cleavage, and cytotoxic activities
No full textChalcones and their pyrazine analogs: synthesis, inhibition of aldose reductase, antioxidant activity, and molecular docking study
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[Et3NH][HSO4] catalyzed efficient synthesis of 5-arylidene-rhodanine conjugates and their antitubercular activity
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QSAR Studies on Chalcones and Flavonoids as Anti-tuberculosis Agents Using Genetic Function Approximation (GFA) Method
No full textAntioxidant and Anti-inflammatory Related Activities of Selected Synthetic Chalcones: Structure–Activity Relationship Studies Using Computational Tools
No full textTS-1 zeolite as a Lewis acid catalyst for solvent-free one-pot synthesis of 1,3-thiazolidin-4-ones
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