2 research outputs found

    Evaluation of Short-Term Effects of Anti-Malaria Drugs on Haematology and Serum Electrolytes in Rats

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    The study investigated the short-term effects of artemether-lumefantrine and chloroquine on haematology and serum electrolytes profile in albino rats. Sixty adult male albino rats, 12–13 weeks of age, weighing 156 – 179 g were procured and used for this study. The rats were assigned into five groups of twelve rats per group replicated 3 times (4 rats per replicate). The groups were: 1. control group (CONTL GRP), 2. high dose artemether Lumefantrine (HD ARTEM LUMF. 4/24 mg/ml), 3. low dose artemether-lumefantrine (LD ARTEM LUMF. 2/12 mg/ml), 4. high dose chloroquine (HD CHLQN. 20 mg/ml) and 5. low dose chloroquine (LD CHLQN. 10 mg/ml)). Rats in the Control group were administered an equivalent volume of placebo (distilled water) according to body weight. Treatment was done daily and lasted for 3 days. The administration was orally using plastic syringes attached to a metal oropharyngeal cannula. Both 4/24 mg/ml and 2/12 mg/ml doses of artemether-lumefantrine showed a non-significant effect (p > 0.05) in WBC, Neu, Lym, Mon, Eos, Bas, RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV, RDW-SD, PLT, MPV, and PDW except in PCT where low (2/12 mg/ml) dose caused a significant increase (p < 0.05) compared with the control. Artemether-lumefantrine and chloroquine had similar effects on K, Na, Cl, iCa, TiCa, TCa, pH, TCO2, and AG. Both high (4/24 mg/ml) and low (2/12 mg/ml) doses of artemether-lumefantrine showed no significant effect (p > 0.05) on K, Na, Cl, iCa, TiCa, TCa, pH, TCO2, and AG but Cl showed a significant increase (p<0.05) compared with the control. Chloroquine doses (20 mg/ml & 10 mg/ml) had similar effects except on Cl where the high dose (20 mg/ml) caused a significant increase (p<0.05) as compared with the control. However, the significant increase in Cl could depict dehydration. Keywords: Artemether-Lumefantrine, Chloroquine, Effects, Haematology, Electrolytes, Rats DOI: 10.7176/ALST/99-01 Publication date:August 31st 202

    Assessment of the Prevalence of Body Mass Index in Some Rural Agro-Settlements, South-East Nigeria

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    This study was focused on the assessment of the prevalence of body mass index in some rural agro-settlements, in south-east Nigeria. A community-based cross-sectional survey design was adopted. A sample size of 400 was randomly selected. Slovin’s formula n=N/ (1 + N*e2) was used to estimate the sample size from the population of 148,415 for Isi-Uzo local government area. The sample size of 385 was rounded up to 400 to ensure inclusiveness and representation of the towns involved. The research examined the prevalence of body mass index (BMI) among residents in the Isi-Uzo Local Government Area, focusing on gender, communities, educational status, and monthly income level. The findings revealed no significant gender-based differences in BMI among the participants, although overweight was more prevalent in males, while underweight, normal weight, and obesity were more prevalent in females. Significant differences in BMI were observed across different communities, with higher rates of underweight and normal weight in Umualor, overweight in Neke, and obesity in Mbu. Regarding educational status, normal BMI was predominant across all levels. Monthly income level also showed significant differences in BMI, with underweight more common among those with no income, normal BMI prevalent among those with a monthly income of ≤ N10,000, overweight higher in the N75,001 to N100,000 income range, and obesity more common in the N100,001 to N150,000 income range. Keywords: Assessment, prevalence, BMI, rural agro-settlements, Isi-Uzo local government area DOI: 10.7176/JBAH/13-14-01 Publication date:August 31st 202
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