Bye-bye Barack: dislocating afropolitanism, spectral marxism and dialectical disillusionment in two Obama-era novels

In contextually specific and formally distinctive ways, Chimamanda Ngozi Adichie’s Americanah and Imbolo Mbue’s Behold the Dreamers are fictional interrogations of Obama’s presidential pledge to resuscitate the American dream on the wake of the global financial crash. This paper explores how they supplement and challenge familiar tropes associated with African and American, rather than African-American, diaspora writing. Given broader debates within transnational literary studies about flows and exchanges (of people, finance, cultural production, dissemination, consumption et al.) linking the global South and North, I consider how these texts grapple with the complexities and complicities of contemporary neoliberalism through the lens of renascent African Marxisms. While my chosen writers could not be described as Marxist, I engage with more materially oriented scholarship, such as Krishnan’s Writing Spatiality in West Africa and Ngugi’s The Rise of the African Novel, to consider how Americanah and Behold the Dreamers circulate in a global literary marketplace where certain texts, not to mention authors, are seen as symptomatic of an African and/or Afropolitan and/or ‘Africapitalist’ renaissance. By grappling with Marxist-inflected scholarship, this paper interrogates the politics, as well as poetics, of the oft-conspicuous airbrushing of those socio-economic, specifically class concerns at the heart of these entangled debates

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

Supervision of Mathematics Programme in Nigerian Schools and Educational Institutions

This paper discussed the concept of mathematics programme and the concept of supervision. Specifically, the paper looked at barriers to effective supervision of mathematics programme in Nigerian educational institutions. The paper adopted the used of secondary data. The secondary data were obtained from online literatures and print publications. The paper concluded Shortage of mathematics Supervisors, inadequate supervision materials, lack of transportation resources, poor funding of supervision, insecurity problems, poor motivation of mathematics Supervisors and poor training of supervisor are the barriers to effective supervision of mathematics programme in educational institutions in Nigeria. Based on tis problems identified, the paper recommended the following: government should increase the funding of instructional supervision in educational institutions across the country especially that of mathematics programme. The government should employ more professional mathematics supervisors in the ministries and agencies to improve quality of mathematics supervision. More supervisory materials should be provided for all mathematics supervisors working in the federal and state ministries and department for effective supervision of mathematics programme and the government should provide adequate transportation facilities for all the departments and agencies in charge of school supervision in the various locations across the federation. &nbsp