The zebrafish as a model for pink1/gba1 deficiency

We examine whether church attendance is related to intergenerational support from children to older parents in Italy. First, we focus on the role of church attendance on different forms of assistance, by distinguishing between practical support and personal assistance. Second, we attempt to disentangle the role of church attendance from that of traditionalism. We analyse data from the ISTAT survey \u2018Family and Social Subject\u2019 2003 using multinomial logistic regression models and the KHB method for the decomposition of direct and indirect effects. Results show the existence of an association between church attendance and the probability of providing practical support to older parents, whereas there is no association with personal assistance. Regular churchgoers are more likely to provide practical support to their parents than the non-catholic, with occasional churchgoers falling somewhere in between. We find little support to the hypothesis that the association between religious practices and intergenerational support is explained by traditional family attitudes, although more traditional children are more likely to live with their parents. In the discussion, we argue that church attendance offers the opportunity for adult children to learn pro-family teachings that are positively related to supportive behaviors in later life

Building back normal? An investigation of practice changes in the charitable and on-the-go food provision sectors through COVID-19

The COVID-19 pandemic has brought about debates on rethinking food and other socio-technical systems. While swiftly re-establishing normality has understandable appeal in a crisis, the landscape-level changes during the pandemic also hold windows of opportunity to “build back better” and to achieve sustainability transitions. In this article, we ask whether a cycle of disruption and adaptation results either in the rise of more sustainable niche practices or the consolidation of the socio-technical regimes in place. To approach this question, we consider the specific cases of charitable and on-the-go food provision and examine the extent to which COVID-induced adaptations have resulted in debates about, and implementations of, more just and sustainable practices. We draw on systems transitions and practice theoretical approaches to elucidate dynamics and elasticity and thus the effect of socio-technical practice changes. After describing the pre-COVID food regimes, we evaluate organizational practice adaptations during the lockdowns with regard to (1) changing cultural images of food security and provision, (2) socio-technical innovations, and (3) new forms of governance. We find that rather than justifying the public and policy frame of “building back better,” the effect of recovery measures reinforces the socio-technical regimes and omits wider sectoral and societal sustainability challenges such as the systemic reduction of poverty and waste

Efficacy and safety of extracranial vein angioplasty in multiple sclerosis: A randomized clinical trial

Importance: Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by restricted venous outflow from the brain and spinal cord. Whether this condition is associated with multiple sclerosis (MS) and whether venous percutaneous transluminal angioplasty (PTA) is beneficial in persons with MS and CCSVI is controversial. Objective: To determine the efficacy and safety of venous PTA in patients with MS and CCSVI. Design, Setting, and Participants: We analyzed 177 patients with relapsing-remitting MS; 62 were ineligible, including 47 (26.6%) who did not have CCSVI on color Doppler ultrasonography screening. A total of 115 patients were recruited in the study timeframe. All patients underwent a randomized, double-blind, sham-controlled, parallel-group trial in 6MS centers in Italy. The trial began in August 2012 and concluded in March 2016; data were analyzed from April 2016 to September 2016. The analysis was intention to treat. Interventions: Patients were randomly allocated (2:1) to either venous PTA or catheter venography without venous angioplasty (sham). Main Outcomes and Measures: Two primary end pointswere assessed at 12 months: (1) a composite functional measure (ie, walking control, balance, manual dexterity, postvoid residual urine volume, and visual acuity) and (2) a measure of new combined brain lesions on magnetic resonance imaging, including the proportion of lesion-free patients. Combined lesions included T1 gadolinium-enhancing lesions plus new or enlarged T2 lesions. Results: Of the included 115 patients with relapsing-remitting MS, 76 were allocated to the PTA group (45 female [59%]; mean [SD] age, 40.0 [10.3] years) and 39 to the sham group (29 female [74%]; mean [SD] age, 37.5 [10.6] years); 112 (97.4%) completed follow-up. No serious adverse events occurred. Flow restoration was achieved in 38 of 71 patients (54%) in the PTA group. The functional composite measure did not differ between the PTA and sham groups (41.7%vs 48.7%; odds ratio, 0.75; 95%CI, 0.34-1.68; P = .49). The mean (SD) number of combined lesions on magnetic resonance imaging at 6 to 12 months were 0.47 (1.19) in the PTA group vs 1.27 (2.65) in the sham group (mean ratio, 0.37; 95%CI, 0.15-0.91; P = .03: adjusted P = .09) and were 1.40 (4.21) in the PTA group vs 1.95 (3.73) in the sham group at 0 to 12 months (mean ratio, 0.72; 95%CI, 0.32-1.63; P = .45; adjusted P = .45). At follow-up after 6 to 12 months, 58 of 70 patients (83%) in the PTA group and 22 of 33 (67%) in the sham group were free of new lesions on magnetic resonance imaging (odds ratio, 2.64; 95%CI, 1.11-6.28; P = .03; adjusted P = .09). At 0 to 12 months, 46 of 73 patients (63.0%) in the PTA group and 18 of 37 (49%) in the sham group were free of new lesions on magnetic resonance imaging (odds ratio, 1.80; 95%CI, 0.81-4.01; P = .15; adjusted P = .30). Conclusion and Relevance: Venous PTA has proven to be a safe but largely ineffective technique; the treatment cannot be recommended in patients with MS

Food Support Provision in COVID19 Times: A Survey Based in Greater Manchester, 2020-2021

The survey aimed to gather data on the impact of the COVID19 outbreak on the food support providers active in Greater Manchester. The lockdown created organizational hurdles to many services providing food to the most vulnerable. The survey explored more in depth the obstacles, the needs and the prospects of 55 organizations that were on the frontline in the first months of the crisis.In the United Kingdom food banks are increasingly required to alleviate hunger and food insecurity. In Greater Manchester (GM) alone, the GM Poverty Alliance mapped 171 emergency food providers. While the renewed interest of social scientists in the topic has produced an abundance of scientific literature, there remains a lack of knowledge on the webs of influence, support, conflict and interdependence between families experiencing food poverty and the emergency food providers. Project HUNG, by embracing a relational approach, focuses on the space of relations occupied by actors and institutions engaged with one another. Thereby, it proposes a relational object of analysis: not food poverty or food banks per se, but rather the interactions and transactions involved in the process of charitable supply and food demand. The project, based on the GM metropolitan county, makes use of quantitative analysis and ethnography of the everyday life to throw light on the "hunger bonds" connecting emergency providers and their users. On the one side, by gathering original survey data on food banks and their users, it provides a descriptive analysis on the determinants of food bank use through a dataset suitable for multilevel modelling (individuals nested in food banks). On the other side, it offers an in-depth ethnography of the daily life of a small sample of families that frequently rely on food banks by shadowing their meal choices for a prolonged period of time. By doing so, HUNG creates twofold added-value for the research community and for policy makers. Scholars nterested in food inequalities will have access to a ethodological toolkit, that could be used to extend research in other metropolitan domains. Simultaneously, by describing in detail the determinants of food bank use, it will improve the capability of agencies fighting food poverty to influence public policies to end food poverty.</p

Building back normal? An investigation of practice changes in the charitable and on-the-go food provision sectors through COVID-19

The COVID-19 pandemic has brought about debates on rethinking food and other socio-technical systems. While swiftly re-establishing normality has understandable appeal in a crisis, the landscape-level changes during the pandemic also hold windows of opportunity to "build back better" and to achieve sustainability transitions. In this article, we ask whether a cycle of disruption and adaptation results either in the rise of more sustainable niche practices or the consolidation of the socio-technical regimes in place. To approach this question, we consider the specific cases of charitable and on-the-go food provision and examine the extent to which COVID-induced adaptations have resulted in debates about, and implementations of, more just and sustainable practices. We draw on systems transitions and practice theoretical approaches to elucidate dynamics and elasticity and thus the effect of socio-technical practice changes. After describing the pre-COVID food regimes, we evaluate organizational practice adaptations during the lockdowns with regard to (1) changing cultural images of food security and provision, (2) socio-technical innovations, and (3) new forms of governance. We find that rather than justifying the public and policy frame of "building back better," the effect of recovery measures reinforces the socio-technical regimes and omits wider sectoral and societal sustainability challenges such as the systemic reduction of poverty and waste

Building back normal? An investigation of practice changes in the charitable and on-the-go food provision sectors through COVID-19

The COVID-19 pandemic has brought about debates on rethinking food and other socio-technical systems. While swiftly re-establishing normality has understandable appeal in a crisis, the landscape-level changes during the pandemic also hold windows of opportunity to "build back better" and to achieve sustainability transitions. In this article, we ask whether a cycle of disruption and adaptation results either in the rise of more sustainable niche practices or the consolidation of the socio-technical regimes in place. To approach this question, we consider the specific cases of charitable and on-the-go food provision and examine the extent to which COVID-induced adaptations have resulted in debates about, and implementations of, more just and sustainable practices. We draw on systems transitions and practice theoretical approaches to elucidate dynamics and elasticity and thus the effect of socio-technical practice changes. After describing the pre-COVID food regimes, we evaluate organizational practice adaptations during the lockdowns with regard to (1) changing cultural images of food security and provision, (2) socio-technical innovations, and (3) new forms of governance. We find that rather than justifying the public and policy frame of "building back better," the effect of recovery measures reinforces the socio-technical regimes and omits wider sectoral and societal sustainability challenges such as the systemic reduction of poverty and waste

Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial

Purpose: To evaluate if jugular vein flow restoration in various venographic defects indicative of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients can have positive effects on cerebral lesions identified using magnetic resonance imaging (MRI). Materials and Methods: The Brave Dreams trial (ClinicalTrials.gov identifier NCT01371760) was a multicenter, randomized, parallel group, double-blind, sham-controlled trial to assess the efficacy of jugular venoplasty in MS patients with CCSVI. Between August 2012 and March 2016, 130 patients (mean age 39.9\ub110.6 years; 81 women) with relapsing/remitting (n=115) or secondary/progressive (n=15) MS were randomized 2:1 to venography plus angioplasty (n=86) or venography (sham; n=44). Patients and study personnel (except the interventionist) were masked to treatment assignment. MRI data acquired at 6 and 12 months after randomization were compared to the preoperative scan for new and/or >30% enlargement of T2 lesions plus new gadolinium enhancement of pre-existing lesions. The relative risks (RR) with 95% confidence interval (CI) were estimated and compared. In a post hoc assessment, venograms of patients who underwent venous angioplasty were graded as \u201cfavorable\u201d (n=38) or \u201cunfavorable\u201d (n=30) for dilation according to the Giaquinta grading system by 4 investigators blinded to outcomes. These subgroups were also compared. Results: Of the 130 patients enrolled, 125 (96%) completed the 12-month MRI follow-up. Analysis showed that the likelihood of being free of new cerebral lesions at 1 year was significantly higher after venoplasty compared to the sham group (RR 1.42, 95% CI 1.00 to 2.01, p=0.032). Patients with favorable venograms had a significantly higher probability of being free of new cerebral lesions than patients with unfavorable venograms (RR 1.82, 95% CI 1.17 to 2.83, p=0.005) or patients in the sham arm (RR 1.66, 95% CI 1.16 to 2.37, p=0.005). Conclusion: Expanded analysis of the Brave Dreams data that included secondary/progressive MS patients in addition to the relapsing/remitting patients analyzed previously showed that venoplasty decreases new cerebral lesions at 1 year. Post hoc analysis confirmed the efficacy of the Giaquinta grading system in selecting patients appropriate for venoplasty who were more likely to be free from accumulation of new cerebral lesions at MRI