Formulation, Development and Evaluation of Fast Dissolving Oral Film of a Selective Serotonin-Reuptake Inhibitor (SSRIS) Escitalopram Oxalate

The purpose of this research was to develop fast dissolving oral film of Escitalopram oxalate. Fast dissolving oral film offers a solution for paediatrics, geriatrics; psychiatric or mentally ill people and those have difficulty in swallowing tablets/capsules resulting in improved patient compliance. Selective serotonin reuptake inhibitors (SSRIs), which are broad spectrum antidepressants that are effective for major depressive disorder and several anxiety disorders. Escitalopram Oxalate is highly selective, more effective and better than other SSRIs. The prepared formulations were evaluated for Thickness, Weight uniformity, Folding Endurance, Percentage of Moisture Content, Drug Content Analysis, Disintegrating time and In vitro dissolution study. Stability studies were carried out with optimized formulation F5 which was stored for a period of one, two and three months at 40±2oC temperature and 75±5% relative humidity for a period 3 months.  Thus it can be concluded that Escitalopram oxalate fast dissolving films could be commercially exploited for the treatment of panic disorder using Escitalopram oxalate with merits of faster onset of action, avoidance of extensive first pass metabolism, low dosage regimen, enhanced bioavailability and improved patient compliance. Keywords: Escitalopram oxalate, Fast dissolving oral film, Evaluatio

Formulation, characterization and evaluation of Tramadol Hydrochloride Hydrogel

The challenge in the formulation of novel systems for TDDS is to identify technologies and formulation excipients which simultaneously optimize drug permeation. Our main goal was to design and evaluate a recent alternative for the administration of tramadol HCl. Performed the preformulation study as different evaluation parameters Physiochemical Studies, Solubility Determination, Partition Coefficient, and Preparation of Calibration Curve simultaneously Preparation & Characterization of Hydrogel Formulation Homogeneity, pH Measurement, Drug Content, Viscosity, Spreadability, In-Vitro Permeation, FT-IR Studies. Results revealed that the present investigation, tramadol was successfully incorporated into different gel formulations. Among all gel formulations, tramadol gel (F13) proved to be the formula of choice, showing good characteristics and controlling the drug release for long period of time. Gel formulation F13 could be very promising and innovative topical alternative for pain management and arthritis and play a vital role in drug efficiency. These findings may open new avenues for the treatment through dermal by local application of tailored gel. However, further preclinical and clinical studies are recommended to support its efficiency claims in humans. Keywords: Tramadol HCl; In-Vitro Permeation; Hydrogel; FT-IR Studies; Characterizatio

Development and Validation of a Green Analytical Method for the Determination of Aspirin and Domperidone Bulk or Formulation Using UV and HPLC

The aim of present study was to investigate the development and validation of a green analytical method for the determination of aspirin and domperidone. Method Development and Validation for Estimation of Domperidone and Aspirin in bulk or formulation by using RP-HPLC. The RP-HPLC method was developed for estimation of Aspirin and Domperidone in synthetic mixture by isocratically using 10 mM KH2PO4: Acetonitrile (20:80) as mobile phase, Prontosil C-18 column (4.6 x 250 mm, 5μparticle size) column as stationary phase and chromatogram was recorded at 231 nm. Then developed method was validated by using various parameters such as, linearity, Range accuracy, precision repeatability, intermediate precision, robustness, limit of detection, limit of quantification. The proposed methods were found to be linear with correlation coefficient close to one. Precision was determined by repeatability, Intermediate precision and reproducibility of the drugs. The robustness of developed method was checked by changing in the deliberate variation in solvent. The result obtained shows the developed methods to be Cost effective, Rapid (Short retention time), Simple, Accurate (the value of SD and % RSD less than 2), Precise and can be successfully employed in the routine analysis of these drugs in bulk drug as well as in tablet dosage form. The Simplicity, Rapidly and Reproducibility of the proposed method completely fulfill the objective of this research work. Keywords: Asprin; Domperidone; HPLC; Ultra Violet; Validatio

Antimicrobial screening of various extracts of Aphanmixis polystachya stems bark

The dried stem bark of Aphanmixis polystachya (Melieceae) was extracted with alcoholic, hydroalcoholic and aqueous solvent for 36 hours in soxhlet apparatus and solvents from extracts was evaporated under vacuum. All three extracts were further fractionized in to the petroleum ether, ethyl acetate and n-butanol fractions and studied for in vitro antimicrobial activity by Agar cup method using different bacterial strains in nutrient agar media. For screening of antimicrobial activity, these extracts of dried stem bark of Aphanmixis polystachya was used at the dose of 500 mcg/cup against the kanamycin, which was used as standard antimicrobial agent at the dose of 30mcg/cup. The zone of inhibitions indicates that the extracts of dried stem bark of Aphanmixis polystachya showed significant antimicrobial activity as comparison to kanamycin.Keywords: Aphanmixis polystachya, Melieceae, Antimicrobial, Kanamycin