Thermodynamic modeling and analysis of the structure of a heat-resistant alloy of the Fe-Cr-Ni system

There has been carried out thermodynamic modeling of phase transformations of the Fe-Cr Ni alloy alloyed with titanium and niobium in order to predict the phase composition and to substantiate the concentration of alloying elements of the experimental alloy for parts of metallurgical equipment. The results of microstructural analysis and phase composition of an experimental heat-resistant alloy are presented

Thermodynamic modeling and analysis of the structure of a heat-resistant alloy of the Fe-Cr-Ni system

There has been carried out thermodynamic modeling of phase transformations of the Fe-Cr Ni alloy alloyed with titanium and niobium in order to predict the phase composition and to substantiate the concentration of alloying elements of the experimental alloy for parts of metallurgical equipment. The results of microstructural analysis and phase composition of an experimental heat-resistant alloy are presented

Central Bank Money: Liability, Asset, or Equity of the Nation?

Source info: Cornell Legal Studies Research Paper 20-46Source info: Cornell Legal Studies Research Paper 20-46Based on legal arguments, we advocate a conceptual and normative shift in our understanding of the economic character of central bank money (CBM). The widespread treatment of CBM as a central bank liability goes back to the gold standard, and uses analogies with commercial bank balance sheets. However, CBM is sui generis and legally not comparable to commercial bank money. Furthermore, in modern economies, CBM holders cannot demand repayment of CBM in anything other than CBM. CBM is not an asset of central banks either, and it is not central bank shareholder equity because it does not confer the same ownership rights as regular shareholder equity. Based on comparisons across a number of legal characteristics of financial instruments, we suggest that an appropriate characterization of CBM is as ‘social equity’ that confers rights of participation in the economy’s payment system and thereby its economy. This interpretation is important for macroeconomic policy in light of quantitative easing and potential future issuance of central bank digital currency (CBDC). It suggests that in robust economies with credible monetary institutions, and where demand for CBM is sufficiently and sustainably high, large-scale issuance such as under CBDC is not inflationary, and it does not weaken public sector finances

Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer

BACKGROUND: Activated forms of Ras are enhanced in both breast cancer as well as the cell lines with EGFR and HER2 expression. Therefore, H-Ras could be activated in breast tumours in the absence of direct mutational activation of Ras itself and could contribute to 20-50% of the cases. Expression inhibition, signal transduction interruption from H-Ras to the nucleus could become a promising therapeutic target. AIM: The aim of this study was to investigate the clinical and morphological criteria of locally advanced breast cancer and the expression of H-Ras oncoprotein in patients who have been subjected to different regimens of farnesyltransferase inhibitor. METHODS: H-Ras status was assessed by immunohistochemistry (IHC). RESULTS: An association between the expressions of H-Ras and Her2/neu (p = 0.001) as well as the tumour proliferation index Ki-67 (p = 0.001) in patients with breast cancer was established. Analysis of the relationship between H-Ras expression showed a relatively strong association with progression-free survival both before the treatment (V = 0.47; p = 0.001) and after the treatment (V = 0.45; p = 0.001). These results may indicate the clinical applicability of H-Ras as a prognostic factor or serve as a therapeutic target for breast cancer treatment. CONCLUSION: These results could indicate the potential clinical application of H-Ras as a prognostic factor or a therapeutic target for breast cancer treatment

Features of clinical manifestations of vaginal dysbacteriosis in women with uterine myoma

In the study of vaginal and cervical canal biocenosis in 67% of women with uterine myoma in the vaginal area, the pattern of bacterial vaginosis was revealed, and Ureaplasma urealiticum was detected in 91% of cases. Very often ureaplasmosis is very often combined with bacterial vaginosis. Given the fact that the surgery for fibroids occupies the first place among gynecological operations, it is necessary to conduct a comprehensive treatment of vaginal dysbacteriosis, which leads to postoperative complications, as well as in women of childbearing age in combination with uterine myoma leads to infertility, to early spontaneous miscarriages, etc.При изучении биоценоза влагалища и цервикального канала у 67% женщин с миомой матки во влагалищном отделяемом выявлена картина бактериального вагиноза и в 91% случаев них обнаружена Ureaplasma urealiticum. Очень часто уреаплазмоз сочетается с бактериальным вагинозом. Учитывая то, что операции по поводу миомы занимают первое место среди гинекологических операций, необходимо проводить комплексное лечение дисбактериоза влагалища, который приводит к послеоперационным осложнениям, а также у женщин детородного возраста в сочетании с миомой матки приводит к бесплодию, к ранним самопроизвольным выкидышам и др

Modern concepts of anal sphincter insufficiency and its treatment

The international clinical analysis of the treatment of topical issues - failure of the anal sphincter, which has not only medical but also social value is presented. The comparative analysis of effectiveness of suggested above operating methods and modern approaches of different surgical methods of anal incontinence correction was conducted.Представлен мировой клинический анализ лечения актуальной проблемы – недостаточности анального сфинктера, которая имеет не только медицинское, но и социальное значение. Проведен сравнительный анализ эффективности как предлагавшихся ранее оперативных вмешательств, так и современные подходы различных хирургических методик коррекции анальной инконтиненции

Epidemiology and etiological factors of the risk of development of urinary disease in Dagestan

То clarify the clinical epidemiology of IBC in RD given site 12123 inpatient and outpatient cards of patients with ICD were analyzed. The average annual indicators of the quality of drinking water in various climatic and geographical zones of the region were studied. The incidence of ICD uneven, with high incidence among residents of planar zones 83,08%, it revealed the highest hardness of the water. The number of ICD patients living in the highlands is much less than USD 11.8%. It is established that increased consumption of animal protein is directly proportional to the increase in the number of ICD patients in the RD. Revealed that the incidence of IBC is higher among women (66,3%) than in men (33.7 per cent).С целью выяснения клинической эпидемиологии МКБ в РД с учетом территории проанализировано 12123 амбулаторных и стационарных карт больных с МКБ. Изучены среднегодовые показатели качества питьевой воды в различных климатогеографических зонах региона. Установлено, что заболеваемость МКБ неравномерна, высокая заболеваемость отмечена у жителей плоскостной зоны 83,08%, здесь выявлены самые высокие показатели жесткости воды. Число больных МКБ проживающих в горных районах намного меньше -11,8%. Установлено, что увеличение потребления животного белка прямо пропорционально увеличению количества больных МКБ вРД. Выявлено, что заболеваемость МКБ у женщин выше (66,3%), чем у мужчин (33,7%)

YIELD AND QUALITY OF SORGHUM IN IRRIGATED AGRO LANDSCAPES OF REPUBLIC OF DAGESTAN

Aim. One of drought-resistant crops that can provide stable high yields is sorghum, which is salt-tolerant, heat-resistant and a flexible crop of versatile use (green forage, silage, hay, grass meal, grain forage). The research conducted in 2010-2013 included studies on the effectiveness of the methods and norms of sowing the sorghum, required quantities of mineral fertilizers to increase the crop yields and nutritional value of sorghum sown in the irrigated lowland areas of Dagestan. Methods. We conducted three field researches. In experiments with grain sorghum (the middle ripening group Zernogradskiy 88) we studied drill and broad-cast methods of sowing, seeding rate, the calculated doses of mineral fertilizers on programmable levels of crop yields: 6 t/ha (N160P112K70), 7 t/ha (N190P128K80) and 8 t/ha (N220P144K90). Seeding rate was 300, 350 and 400 thousand viable seeds per 1 ha; broadcast was chosen as a sowing method.A field experiment with sweet sorghum included promising hybrid crop Debut, fertilizers N140P80K70, N190P110K95 and N240P140K120 to obtain 60, 70 and 80 t/ha of green mass for two mowings, respectively. Results. The use of fertilizers based on a given level of productivity at optimum plant population can significantly improve the nutritional regime of the soil during the growing season of the sweet sorghum and create optimal conditions for nitrogen, phosphorus and potassium security for the crops and thus obtain the planned crop yield. Conclusion. The fodder quality of sweet sorghum varies depending on the nutrient status of the soil and mowing time

Modern principles oftreatment of vaginal dysbiosisin women with uterine Myoma

According to world statistics, about 30% of women are subjected to surgery on the genitals, and 1 place is occupied by surgery for uterine fibroids. In the study of biocenosis of the vagina and cervical canal in 67% of women with uterine fibroids in the vaginal discharge revealed a pattern of bacterial vaginosis. To date, the issue of complex treatment of vaginal dysbiosis in patients with uterine myoma remains relevant and insufficiently studied. The frequency of pyo-inflammatory postoperative diseases is increased in women with all types of vaginal microcenosis. Considering that operations concerning uterine fibroids take the first place among gynecologic operations, it is necessary to carry out complex treatment of a dysbacteriosis of a vagina which leads to postoperative complications.Согласно мировой статистике, около 30% женщин подвергаются хирургическим вмешательствам на половых органах, причем 1 место занимают операции по поводу миомы матки. При изучении биоценоза влагалища и цервикального канала у 67% женщин с миомой матки во влагалищном отделяемом выявлена картина бактериального вагиноза. На сегодняшний день остается актуальным и недостаточно изученным вопрос о комплексном лечении дисбактериоза влагалища у больных с миомой матки. Частота гнойно-воспалительных послеоперационных заболеваний повышена у женщин со всеми видами нарушения влагалищного микроциноза. Учитывая то, что операции по поводу миомы матки занимают первое место среди гинекологических операций, необходимо проводить комплексное лечение дисбактериоза влагалища, который приводит к послеоперационным осложнениям